Open Access

A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study

  • Authors:
    • Nicholas B. Blackburn
    • Jac C. Charlesworth
    • James R. Marthick
    • Elizabeth M. Tegg
    • Katherine A. Marsden
    • Velandai Srikanth
    • John Blangero
    • Ray M. Lowenthal
    • Simon J. Foote
    • Joanne L. Dickinson
  • View Affiliations

  • Published online on: October 24, 2014     https://doi.org/10.3892/or.2014.3568
  • Pages: 25-32
  • Copyright: © Blackburn et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Telomere length has a biological link to cancer, with excessive telomere shortening leading to genetic instability and resultant malignant transformation. Telomere length is heritable and genetic variants determining telomere length have been identified. Telomere biology has been implicated in the development of hematological malignancies (HMs), therefore, closer examination of telomere length in HMs may provide further insight into genetic etiology of disease development and support for telomere length as a prognostic factor in HMs. We retrospectively examined mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study using a quantitative PCR method on genomic DNA from peripheral blood samples. Fifty-five familial HM cases, 191 unaffected relatives of familial HM cases and 75 non-familial HM cases were compared with 758 population controls. Variance components modeling was employed to identify factors influencing variation in telomere length. Overall, HM cases had shorter mean relative telomere length (p=2.9×10-6) and this was observed across both familial and non-familial HM cases (p=2.2x10-4 and 2.2x10-5, respectively) as well as additional subgroupings of HM cases according to broad subtypes. Mean relative telomere length was also significantly heritable (62.6%; p=4.7x10-5) in the HM families in the present study. We present new evidence of significantly shorter mean relative telomere length in both familial and non-familial HM cases from the same population adding further support to the potential use of telomere length as a prognostic factor in HMs. Whether telomere shortening is the cause of or the result of HMs is yet to be determined, but as telomere length was found to be highly heritable in our HM families this suggests that genetics driving the variation in telomere length is related to HM disease risk.
View Figures
View References

Related Articles

Journal Cover

January-2015
Volume 33 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Blackburn NB, Charlesworth JC, Marthick JR, Tegg EM, Marsden KA, Srikanth V, Blangero J, Lowenthal RM, Foote SJ, Dickinson JL, Dickinson JL, et al: A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study. Oncol Rep 33: 25-32, 2015.
APA
Blackburn, N.B., Charlesworth, J.C., Marthick, J.R., Tegg, E.M., Marsden, K.A., Srikanth, V. ... Dickinson, J.L. (2015). A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study. Oncology Reports, 33, 25-32. https://doi.org/10.3892/or.2014.3568
MLA
Blackburn, N. B., Charlesworth, J. C., Marthick, J. R., Tegg, E. M., Marsden, K. A., Srikanth, V., Blangero, J., Lowenthal, R. M., Foote, S. J., Dickinson, J. L."A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study". Oncology Reports 33.1 (2015): 25-32.
Chicago
Blackburn, N. B., Charlesworth, J. C., Marthick, J. R., Tegg, E. M., Marsden, K. A., Srikanth, V., Blangero, J., Lowenthal, R. M., Foote, S. J., Dickinson, J. L."A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study". Oncology Reports 33, no. 1 (2015): 25-32. https://doi.org/10.3892/or.2014.3568