1
|
Nieto MA: The ins and outs of the
epithelial to mesenchymal transition in health and disease. Annu
Rev Cell Dev Biol. 27:347–376. 2011. View Article : Google Scholar : PubMed/NCBI
|
2
|
Savagner P, Yamada KM and Thiery JP: The
zinc-finger protein slug causes desmosome dissociation, an initial
and necessary step for growth factor-induced epithelial-mesenchymal
transition. J Cell Biol. 137:1403–1419. 1997. View Article : Google Scholar : PubMed/NCBI
|
3
|
Thiery JP: Epithelial-mesenchymal
transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Chang CJ, Chao CH, Xia W, Yang JY, Xiong
Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, et al: p53 regulates
epithelialmesenchymal transition and stem cell properties through
modulating miRNAs. Nat Cell Biol. 13:317–323. 2011. View Article : Google Scholar : PubMed/NCBI
|
5
|
Gravdal K, Halvorsen OJ, Haukaas SA and
Akslen LA: A switch from E-cadherin to N-cadherin expression
indicates epithelial to mesenchymal transition and is of strong and
independent importance for the progress of prostate cancer. Clin
Cancer Res. 13:7003–7011. 2007. View Article : Google Scholar : PubMed/NCBI
|
6
|
Hader C, Marlier A and Cantley L:
Mesenchymal-epithelial transition in epithelial response to injury:
The role of Foxc2. Oncogene. 29:1031–1040. 2010. View Article : Google Scholar :
|
7
|
Suzuki A, Kusakai G, Kishimoto A, Lu J,
Ogura T, Lavin MF and Esumi H: Identification of a novel protein
kinase mediating Akt survival signaling to the ATM protein. J Biol
Chem. 278:48–53. 2003. View Article : Google Scholar
|
8
|
Suzuki A, Kusakai G, Kishimoto A, Lu J,
Ogura T and Esumi H: ARK5 suppresses the cell death induced by
nutrient starvation and death receptors via inhibition of caspase 8
activation, but not by chemotherapeutic agents or UV irradiation.
Oncogene. 22:6177–6182. 2003. View Article : Google Scholar : PubMed/NCBI
|
9
|
Suzuki A, Kusakai G, Kishimoto A, Shimojo
Y, Miyamoto S, Ogura T, Ochiai A and Esumi H: Regulation of
caspase-6 and FLIP by the AMPK family member ARK5. Oncogene.
23:7067–7075. 2004. View Article : Google Scholar : PubMed/NCBI
|
10
|
Kusakai G, Suzuki A, Ogura T, Kaminishi M
and Esumi H: Strong association of ARK5 with tumor invasion and
metastasis. J Exp Clin Cancer Res. 23:263–268. 2004.PubMed/NCBI
|
11
|
Kusakai G, Suzuki A, Ogura T, Miyamoto S,
Ochiai A, Kaminishi M and Esumi H: ARK5 expression in colorectal
cancer and its implications for tumor progression. Am J Pathol.
164:987–995. 2004. View Article : Google Scholar : PubMed/NCBI
|
12
|
Suzuki A, Lu J, Kusakai G, Kishimoto A,
Ogura T and Esumi H: ARK5 is a tumor invasion-associated factor
downstream of Akt signaling. Mol Cell Biol. 24:3526–3535. 2004.
View Article : Google Scholar : PubMed/NCBI
|
13
|
Chen P, Li K, Liang Y, Li L and Zhu X:
High NUAK1 expression correlates with poor prognosis and involved
in NSCLC cells migration and invasion. Exp Lung Res. 39:9–17. 2013.
View Article : Google Scholar
|
14
|
Shi L, Zhang B, Sun X, Lu S, Liu Z, Liu Y,
Li H, Wang L, Wang X and Zhao C: MiR-204 inhibits human NSCLC
metastasis through suppression of NUAK1. Br J Cancer.
111:2316–2327. 2014. View Article : Google Scholar : PubMed/NCBI
|
15
|
Bell RE, Khaled M, Netanely D, Schubert S,
Golan T, Buxbaum A, Janas MM, Postolsky B, Goldberg MS, Shamir R,
et al: Transcription factor/microRNA axis blocks melanoma invasion
program by miR-211 targeting NUAK1. J Invest Dermatol. 134:441–451.
2014. View Article : Google Scholar
|
16
|
Lu S, Niu N, Guo H, Tang J, Guo W, Liu Z,
Shi L, Sun T, Zhou F, Li H, et al: ARK5 promotes glioma cell
invasion, and its elevated expression is correlated with poor
clinical outcome. Eur J Cancer. 49:752–763. 2013. View Article : Google Scholar
|
17
|
Chang XZ, Yu J, Liu HY, Dong RH and Cao
XC: ARK5 is associated with the invasive and metastatic potential
of human breast cancer cells. J Cancer Res Clin Oncol. 138:247–254.
2012. View Article : Google Scholar
|
18
|
Cui J, Yu Y, Lu GF, Liu C, Liu X, Xu YX
and Zheng PY: Overexpression of ARK5 is associated with poor
prognosis in hepatocellular carcinoma. Tumour Biol. 34:1913–1918.
2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
Lee RC, Feinbaum RL and Ambros V: The C.
elegans heterochronic gene lin-4 encodes small RNAs with antisense
complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI
|
20
|
Pasquinelli AE, Reinhart BJ, Slack F,
Martindale MQ, Kuroda MI, Maller B, Hayward DC, Ball EE, Degnan B,
Müller P, et al: Conservation of the sequence and temporal
expression of let-7 heterochronic regulatory RNA. Nature.
408:86–89. 2000. View
Article : Google Scholar : PubMed/NCBI
|
21
|
Reinhart BJ, Slack FJ, Basson M,
Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G:
The 21-nucleotide let-7 RNA regulates developmental timing in
Caenorhabditis elegans. Nature. 403:901–906. 2000. View Article : Google Scholar : PubMed/NCBI
|
22
|
Esteller M: Non-coding RNAs in human
disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Esquela-Kerscher A and Slack FJ:
Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer.
6:259–269. 2006. View
Article : Google Scholar : PubMed/NCBI
|
24
|
Garzon R, Calin GA and Croce CM: MicroRNAs
in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar : PubMed/NCBI
|
25
|
Slack FJ and Weidhaas JB: MicroRNA in
cancer prognosis. N Engl J Med. 359:2720–2722. 2008. View Article : Google Scholar : PubMed/NCBI
|
26
|
Jiang J, Li Z, Yu C, Chen M, Tian S and
Sun C: MiR-1181 inhibits stem cell-like phenotypes and suppresses
SOX2 and STAT3 in human pancreatic cancer. Cancer Lett.
356:962–970. 2015. View Article : Google Scholar
|
27
|
Polyak K and Weinberg RA: Transitions
between epithelial and mesenchymal states: Acquisition of malignant
and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI
|
28
|
Liao XH, Lu DL, Wang N, Liu LY, Wang Y, Li
YQ, Yan TB, Sun XG, Hu P and Zhang TC: Estrogen receptor α mediates
proliferation of breast cancer MCF-7 cells via a
p21/PCNA/E2F1-dependent pathway. FEBS J. 281:927–942. 2014.
View Article : Google Scholar
|
29
|
Zuo JH, Zhu W, Li MY, Li XH, Yi H, Zeng
GQ, Wan XX, He QY, Li JH, Qu JQ, et al: Activation of EGFR promotes
squamous carcinoma SCC10A cell migration and invasion via inducing
EMT-like phenotype change and MMP-9-mediated degradation of
E-cadherin. J Cell Biochem. 112:2508–2517. 2011. View Article : Google Scholar : PubMed/NCBI
|
30
|
Jung H, Lee KP, Park SJ, Park JH, Jang YS,
Choi SY, Jung JG, Jo K, Park DY, Yoon JH, et al: TMPRSS4 promotes
invasion, migration and metastasis of human tumor cells by
facilitating an epithelial-mesenchymal transition. Oncogene.
27:2635–2647. 2008. View Article : Google Scholar
|
31
|
Christiansen JJ and Rajasekaran AK:
Reassessing epithelial to mesenchymal transition as a prerequisite
for carcinoma invasion and metastasis. Cancer Res. 66:8319–8326.
2006. View Article : Google Scholar : PubMed/NCBI
|
32
|
Bracken CP, Gregory PA, Kolesnikoff N,
Bert AG, Wang J, Shannon MF and Goodall GJ: A double-negative
feedback loop between ZEB1-SIP1 and the microRNA-200 family
regulates epithelial-mesenchymal transition. Cancer Res.
68:7846–7854. 2008. View Article : Google Scholar : PubMed/NCBI
|
33
|
Gregory PA, Bracken CP, Bert AG and
Goodall GJ: MicroRNAs as regulators of epithelial-mesenchymal
transition. Cell Cycle. 7:3112–3118. 2008. View Article : Google Scholar : PubMed/NCBI
|
34
|
Korpal M, Lee ES, Hu G and Kang Y: The
miR-200 family inhibits epithelial-mesenchymal transition and
cancer cell migration by direct targeting of E-cadherin
transcriptional repressors ZEB1 and ZEB2. J Biol Chem.
283:14910–14914. 2008. View Article : Google Scholar : PubMed/NCBI
|
35
|
Ma L, Young J, Prabhala H, Pan E, Mestdagh
P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S,
et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin
and cancer metastasis. Nat Cell Biol. 12:247–256. 2010.PubMed/NCBI
|
36
|
Li B, Jin H, Yu Y, Gu C, Zhou X, Zhao N
and Feng Y: HOXA10 is overexpressed in human ovarian clear cell
adenocarcinoma and correlates with poor survival. Int J Gynecol
Cancer. 19:1347–1352. 2009. View Article : Google Scholar : PubMed/NCBI
|
37
|
Tsuji T, Ibaragi S and Hu GF:
Epithelial-mesenchymal transition and cell cooperativity in
metastasis. Cancer Res. 69:7135–7139. 2009. View Article : Google Scholar : PubMed/NCBI
|
38
|
Gavert N and Ben-Ze'ev A:
Epithelial-mesenchymal transition and the invasive potential of
tumors. Trends Mol Med. 14:199–209. 2008. View Article : Google Scholar : PubMed/NCBI
|
39
|
Larue L and Bellacosa A:
Epithelial-mesenchymal transition in development and cancer: Role
of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene.
24:7443–7454. 2005. View Article : Google Scholar : PubMed/NCBI
|
40
|
Vasioukhin V, Bauer C, Degenstein L, Wise
B and Fuchs E: Hyperproliferation and defects in epithelial
polarity upon conditional ablation of alpha-catenin in skin. Cell.
104:605–617. 2001. View Article : Google Scholar : PubMed/NCBI
|
41
|
Schlegelmilch K, Mohseni M, Kirak O,
Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J,
Brummelkamp TR, et al: Yap1 acts downstream of α-catenin to control
epidermal proliferation. Cell. 144:782–795. 2011. View Article : Google Scholar : PubMed/NCBI
|
42
|
Masszi A, Di Ciano C, Sirokmány G, Arthur
WT, Rotstein OD, Wang J, McCulloch CA, Rosivall L, Mucsi I and
Kapus A: Central role for Rho in TGF-beta1-induced alpha-smooth
muscle actin expression during epithelial-mesenchymal transition.
Am J Physiol Renal Physiol. 284:F911–F924. 2003. View Article : Google Scholar
|
43
|
Cano A, Pérez-Moreno MA, Rodrigo I,
Locascio A, Blanco MJ, del Barrio MG, Portillo F and Nieto MA: The
transcription factor snail controls epithelial-mesenchymal
transitions by repressing E-cadherin expression. Nat Cell Biol.
2:76–83. 2000. View Article : Google Scholar : PubMed/NCBI
|
44
|
Kang Y and Massagué J:
Epithelial-mesenchymal transitions: Twist in development and
metastasis. Cell. 118:277–279. 2004. View Article : Google Scholar : PubMed/NCBI
|
45
|
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan
A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The
epithelial-mesenchymal transition generates cells with properties
of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI
|
46
|
Cheng W, Jiang Y, Liu C, Shen O, Tang W
and Wang X: Identification of aberrant promoter hypomethylation of
HOXA10 in ovarian cancer. J Cancer Res Clin Oncol. 136:1221–1227.
2010. View Article : Google Scholar : PubMed/NCBI
|