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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells

  • Authors:
    • Simon J. Crabb
    • Angela Hague
    • Peter W.M. Johnson
    • Graham Packham

  • View Affiliations / Copyright

    Affiliations: Cancer Research UK Clinical Centre, Cancer Sciences Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
  • Pages: 689-696
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.689
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Abstract

BAG-1 is a pleiotropic protein that exists as multiple isoforms. BAG-1 overexpression in breast cancer is associated with outcome. BAG-1 modulates the function of various nuclear hormone receptors, including the oestrogen receptor, and BAG-1 can influence the in vitro action of anti-hormonal therapies such as cyproterone acetate in prostate cancer. Activation of PPARγ, a nuclear hormone receptor important for lipid and glucose homeostasis, may present a new therapeutic approach for breast cancer, since PPARγ agonists promote cell cycle arrest, differentiation and apoptosis in breast cancer cells. Here we determined whether BAG-1 also modulated PPARγ function in MCF7 cells. 15-deoxy-Delta12, 14-prostaglandin J(2) (15dPGJ2), an agonistic ligand for PPARγ, induced expression of HSP70, a BAG-1 binding partner, but did not alter BAG-1 isoform expression. Overexpression of BAG-1 isoforms did not alter PPARγ-dependent transcription or interfere with 15dPGJ2-induced cell cycle arrest or differentiation. However, overexpression of BAG-1 isoforms did interfere with induction of cell death by 15dPGJ2. Thus, BAG-1 is unlikely to directly modulate PPARγ function, but the overexpression of BAG-1 in some breast cancers may limit the efficacy of PPARγ agonists as cancer therapies, by suppression of PPARγ-induced cell death pathways.

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Copy and paste a formatted citation
Spandidos Publications style
Crabb SJ, Hague A, Johnson PW and Packham G: BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells. Oncol Rep 19: 689-696, 2008.
APA
Crabb, S.J., Hague, A., Johnson, P.W., & Packham, G. (2008). BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells. Oncology Reports, 19, 689-696. https://doi.org/10.3892/or.19.3.689
MLA
Crabb, S. J., Hague, A., Johnson, P. W., Packham, G."BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells". Oncology Reports 19.3 (2008): 689-696.
Chicago
Crabb, S. J., Hague, A., Johnson, P. W., Packham, G."BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells". Oncology Reports 19, no. 3 (2008): 689-696. https://doi.org/10.3892/or.19.3.689
Copy and paste a formatted citation
x
Spandidos Publications style
Crabb SJ, Hague A, Johnson PW and Packham G: BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells. Oncol Rep 19: 689-696, 2008.
APA
Crabb, S.J., Hague, A., Johnson, P.W., & Packham, G. (2008). BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells. Oncology Reports, 19, 689-696. https://doi.org/10.3892/or.19.3.689
MLA
Crabb, S. J., Hague, A., Johnson, P. W., Packham, G."BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells". Oncology Reports 19.3 (2008): 689-696.
Chicago
Crabb, S. J., Hague, A., Johnson, P. W., Packham, G."BAG-1 inhibits PPARγ-induced cell death, but not PPARγ-induced transcription, cell cycle arrest or differentiation in breast cancer cells". Oncology Reports 19, no. 3 (2008): 689-696. https://doi.org/10.3892/or.19.3.689
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