The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. V. Post-mortem findings
- Authors:
- Zoheir Mellouk
- Karim Louchami
- Emeline Hupkens
- Abdullah Sener
- Dalila Ait Yahia
- Willy J. Malaisse
View Affiliations
Affiliations: Department of Biology, Es-Sénia University, Es-Sénia 31000, Oran, Algeria, Laboratory of Experimental Hormonology, Université Libre de Bruxelles, B-1070 Brussels, Belgium
- Published online on: September 20, 2012 https://doi.org/10.3892/mmr.2012.1091
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Pages:
1399-1403
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Abstract
The present study deals with the possible effects of dietary ω3 and ω6 fatty acids upon the metabolic syndrome found in rats exposed for 8 weeks to a diet containing 64% (w/w) D-fructose instead of starch. Fructose-fed rats were found to display a modest increase in plasma albumin and protein concentration and more pronounced increases in plasma urea, creatinine, phospholipids, triglycerides and cholesterol concentrations, glycated hemoglobin concentration and liver contents of cholesterol, triglycerides and phospholipids. The plasma concentrations of HDL-cholesterol, calcium and iron were decreased, however, in the fructose-fed rats. In general, the partial substitution of sunflower oil by either safflower oil or salmon oil opposed the metabolic perturbations otherwise associated with the fructose-induced metabolic syndrome in the fructose-fed rats, with salmon oil demonstrating particular efficacy. Consideration is given to the possible biological determinants of these perturbations and their attenuation in rats exposed to safflower or salmon oil.
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