Nucleolin identified by comparative mass‑spectra analysis is a potential marker for invasive progression of hepatocellular carcinoma

Qian,Bin; Yao,Yusheng; Liu,Yihong; Yan,Maolin; Huang,Ying; Chen,Yanqing

doi:10.3892/mmr.2014.2321

Nucleolin identified by comparative mass‑spectra analysis is a potential marker for invasive progression of hepatocellular carcinoma

Authors:
- Bin Qian
- Yusheng Yao
- Yihong Liu
- Maolin Yan
- Ying Huang
- Yanqing Chen
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Affiliations: Department of Anesthesiology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Department of Anesthesiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Diabetic Center of Control and Prevention, The PLA 520 Hospital, Mianyang, Sichuan 621000, P.R. China, Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Pathology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
Published online on: June 13, 2014 https://doi.org/10.3892/mmr.2014.2321
Pages: 1489-1494

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Abstract

At present, the diagnosis and prognosis of hepatocellular carcinoma (HCC) metastasis remains poor. Recently, a number of proteins associated with the metastasis and invasion of HCC were identified; however, the effective markers require further elucidation. In the current study, a nucleolin expression was observed in MHCC97L and HCCLM9 HCC cell lines, with low and high metastatic potentials respectively, using comparative proteomics. The data indicated that nucleolin expression in the nucleus was significantly higher in HCCLM9 cells, and it primarily influenced the migration of HCC cells in vitro. Thus, to the best of our knowledge this is the first study to hypothesize that nucleolin may be a novel marker for HCC invasive progression.

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