Open Access

Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)

  • Authors:
    • Bixian Chen
    • Jing Guo
    • Hongmei Ye
    • Xinyu Wang
    • Yufei Feng
  • View Affiliations

  • Published online on: March 11, 2024     https://doi.org/10.3892/mmr.2024.13197
  • Article Number: 73
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiovascular diseases are caused by pathological cardiac remodeling, which involves fibrosis, inflammation and cell dysfunction. This includes autophagy, apoptosis, oxidative stress, mitochondrial dysfunction, changes in energy metabolism, angiogenesis and dysregulation of signaling pathways. These changes in heart structure and/or function ultimately result in heart failure. In an effort to prevent this, multiple cardiovascular outcome trials have demonstrated the cardiac benefits of sodium‑glucose cotransporter type 2 inhibitors (SGLT2is), hypoglycemic drugs initially designed to treat type 2 diabetes mellitus. SGLT2is include empagliflozin and dapagliflozin, which are listed as guideline drugs in the 2021 European Guidelines for Heart Failure and the 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America Guidelines for Heart Failure Management. In recent years, multiple studies using animal models have explored the mechanisms by which SGLT2is prevent cardiac remodeling. This article reviews the role of SGLT2is in cardiac remodeling induced by different etiologies to provide a guideline for further evaluation of the mechanisms underlying the inhibition of pathological cardiac remodeling by SGLT2is, as well as the development of novel drug targets.
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May-2024
Volume 29 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Chen B, Guo J, Ye H, Wang X and Feng Y: Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review). Mol Med Rep 29: 73, 2024
APA
Chen, B., Guo, J., Ye, H., Wang, X., & Feng, Y. (2024). Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review). Molecular Medicine Reports, 29, 73. https://doi.org/10.3892/mmr.2024.13197
MLA
Chen, B., Guo, J., Ye, H., Wang, X., Feng, Y."Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)". Molecular Medicine Reports 29.5 (2024): 73.
Chicago
Chen, B., Guo, J., Ye, H., Wang, X., Feng, Y."Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)". Molecular Medicine Reports 29, no. 5 (2024): 73. https://doi.org/10.3892/mmr.2024.13197