MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)

Jung,Woohyeong; Juang,Uijin; Gwon,Suhwan; Nguyen,Hounggiang; Huang,Qingzhi; Lee,Soohyeon; Lee,Beomwoo; Kwon,So-Hee; Kim,Seon-Hwan; Park,Jongsun

doi:10.3892/mmr.2024.13222

MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)

Authors:
- Woohyeong Jung
- Uijin Juang
- Suhwan Gwon
- Hounggiang Nguyen
- Qingzhi Huang
- Soohyeon Lee
- Beomwoo Lee
- So-Hee Kwon
- Seon-Hwan Kim
- Jongsun Park
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Affiliations: Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea, College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, Republic of Korea, Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
Published online on: April 9, 2024 https://doi.org/10.3892/mmr.2024.13222
Article Number: 98
Copyright: © Jung et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Muscular atrophy, which results in loss of muscle mass and strength, is a significant concern for patients with various diseases. It is crucial to comprehend the molecular mechanisms underlying this condition to devise targeted treatments. MicroRNAs (miRNAs) have emerged as key regulators of gene expression, serving vital roles in numerous cellular processes, including the maintenance of muscle stability. An intricate network of miRNAs finely regulates gene expression, influencing pathways related to muscle protein production, and muscle breakdown and regeneration. Dysregulation of specific miRNAs has been linked to the development of muscular atrophy, affecting important signaling pathways including the protein kinase B/mTOR and ubiquitin‑proteasome systems. The present review summarizes recent work on miRNA patterns associated with muscular atrophy under various physiological and pathological conditions, elucidating its intricate regulatory networks. In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.

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