Open Access

A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells

  • Authors:
    • Shi‑Gang Qi
    • Li‑Qiu Quan
    • Xiao‑Yue Cui
    • Hong‑Mei Li
    • Xu‑Dong Zhao
    • Rong‑Tao Li
  • View Affiliations

  • Published online on: December 23, 2019     https://doi.org/10.3892/ol.2019.11239
  • Pages: 1384-1392
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore, GSCs have become a new target for tumor treatment and are used in drug screening. Rupesin E is a natural compound obtained from Valeriana jatamansi, and its antitumor activity has not been reported. In the present study, the antitumor activity of rupesin E was investigated, and the results demonstrated that it inhibited the proliferation of GSCs (GSC‑3#, GSC‑12#, GSC‑18#) with the IC50 values of 7.13±1.41, 13.51±1.46 and 4.44±0.22 µg/ml, respectively. In addition, immunofluorescence cell staining and flow cytometry techniques demonstrated that rupesin E inhibited GSC proliferation and induced apoptosis. Furthermore, rupesin E inhibited the ability of GSC colony formation, indicating its antitumor activity against GSCs in vitro.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Qi SG, Quan LQ, Cui XY, Li HM, Zhao XD and Li RT: A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells. Oncol Lett 19: 1384-1392, 2020
APA
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., & Li, R. (2020). A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells. Oncology Letters, 19, 1384-1392. https://doi.org/10.3892/ol.2019.11239
MLA
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., Li, R."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells". Oncology Letters 19.2 (2020): 1384-1392.
Chicago
Qi, S., Quan, L., Cui, X., Li, H., Zhao, X., Li, R."A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells". Oncology Letters 19, no. 2 (2020): 1384-1392. https://doi.org/10.3892/ol.2019.11239