Open Access

Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma

  • Authors:
    • Terufumi Yoshida
    • Kazuko Sakai
    • Masaki Kaibori
    • Mitsuaki Ishida
    • Shogo Tanaka
    • Shoji Kubo
    • Takuya Nakai
    • Marco A. De Velasco
    • Hideyuki Matsushima
    • Koji Tsuta
    • Mitsugu Sekimoto
    • Kazuto Nishio
  • View Affiliations

  • Published online on: January 26, 2024     https://doi.org/10.3892/ol.2024.14257
  • Article Number: 124
  • Copyright: © Yoshida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sarcomatoid hepatocellular carcinoma (SHCC) is a rare and highly lethal subtype of HCC. The present study aimed to explore the unique markers of SHCC using whole gene expression analysis. Subsequently, gene expression analysis was performed using five sarcomatoid and seven carcinomatoid components of seven tissues from patients with SHCC. The results demonstrated a significant downregulation of polybromo 1 (PBRM1) gene expression in the sarcomatoid components. Immunohistochemical staining also indicated a decreased expression of PBRM1 in the sarcomatoid components. Moreover, gene ontology enrichment analysis revealed that most of the 336 differentially expressed genes between the sarcomatoid and carcinomatoid components were involved in functions associated with DNA replication and histone methylation, which was consistent with the loss of function of PBRM1 which encodes Switch/sucrose‑non‑fermentable chromatin remodeling complex protein. Therefore, the results of the present study suggested that PBRM1 may be a candidate biomarker for the evaluation of SHCC.
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March-2024
Volume 27 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yoshida T, Sakai K, Kaibori M, Ishida M, Tanaka S, Kubo S, Nakai T, De Velasco MA, Matsushima H, Tsuta K, Tsuta K, et al: Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncol Lett 27: 124, 2024
APA
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S. ... Nishio, K. (2024). Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncology Letters, 27, 124. https://doi.org/10.3892/ol.2024.14257
MLA
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S., Nakai, T., De Velasco, M. A., Matsushima, H., Tsuta, K., Sekimoto, M., Nishio, K."Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma". Oncology Letters 27.3 (2024): 124.
Chicago
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S., Nakai, T., De Velasco, M. A., Matsushima, H., Tsuta, K., Sekimoto, M., Nishio, K."Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma". Oncology Letters 27, no. 3 (2024): 124. https://doi.org/10.3892/ol.2024.14257