Journal Articles

Review

Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)

Jianhong Zhu, Handong Wang, Youwu Fan, Yixing Lin, Li  Zhang, Xiangjun Ji, Mengliang Zhou

Pages: 443-450 Published online on: 12 June 2014
Review

Clinical evidence of the relationship between aspirin and breast cancer risk (Review)

Nadia J. Jacobo-Herrera, Carlos Pérez-Plasencia, Elizabeth  Camacho‑Zavala, Gabriela Figueroa González, Eduardo López Urrutia, Verónica  García‑Castillo, Alejandro Zentella-Dehesa

Pages: 451-451 Published online on: 13 June 2014
Article Open Access

hBD-2 is downregulated in oral carcinoma cells by DNA hypermethylation, and increased expression of hBD-2 by DNA demethylation and gene transfection inhibits cell proliferation and invasion

Yoshitaka Kamino, Yoshihito Kurashige, Osamu Uehara, Jun Sato, Michiko Nishimura, Koki Yoshida, Toshiya Arakawa, Hiroki Nagayasu, Masato Saitoh, Yoshihiro Abiko

Pages: 462-468 Published online on: 12 June 2014
Article Open Access

Gli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug

Lauren Amable, Jason Fain, Elaine Gavin, Eddie Reed

Pages: 469-474 Published online on: 12 June 2014
Article Open Access

Combined effects of asbestos and cigarette smoke on the development of lung adenocarcinoma: Different carcinogens may cause different genomic changes

Kentaro Inamura, Hironori Ninomiya, Kimie  Nomura, Eiju  Tsuchiya, Yukitoshi  Satoh, Sakae  Okumura, Ken  Nakagawa, Ayako  Takata, Norihiko  Kohyama, Yuichi  Ishikawa

Pages: 475-482 Published online on: 13 June 2014
Article Open Access

Genomic characterization of ependymomas reveals 6q loss as the most common aberration

Thale Kristin Olsen, Ludmila Gorunova, Torstein R. Meling, Francesca Micci, David Scheie, Bernt Due-Tønnessen, Sverre Heim, Petter Brandal

Pages: 483-490 Published online on: 16 June 2014
Article Open Access

Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment

Magdalena Milczarek, Beata Filip-Psurska, Wiesław Świętnicki, Andrzej Kutner, Joanna Wietrzyk

Pages: 491-504 Published online on: 11 June 2014
Article Open Access

Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity

Rafael Guerrero-Preston, Tal  Hadar, Kimberly  Laskie Ostrow, Ethan  Soudry, Miguel  Echenique, Carmen  Ili-Gangas, Gabriela  Pérez, Jimena  Perez, Priscilla  Brebi-Mieville, José  Deschamps, Luisa  Morales, Manuel  Bayona, David  Sidransky, Jaime  Matta

Pages: 505-512 Published online on: 13 June 2014
Article Open Access

PP2A inhibitors suppress migration and growth of PANC-1 pancreatic cancer cells through inhibition on the Wnt/β-catenin pathway by phosphorylation and degradation of β-catenin

Meng-Yao Wu, Xin Xie, Ze-Kuan Xu, Li Xie, Zheng Chen, Liu‑Mei  Shou, Fei-Ran Gong, Yu-Feng Xie, Wei Li, Min Tao

Pages: 513-522 Published online on: 13 June 2014
Article Open Access

Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer

Vincent Richard, Nadège Kindt, Christine Decaestecker, Hans‑Joachim Gabius, Guy Laurent, Jean-Christophe Noël, Sven Saussez

Pages: 523-529 Published online on: 16 June 2014
Article

Prognostic factors in Epstein-Barr virus-associated stage I-III gastric carcinoma: Implications for a unique type of carcinogenesis

Shih-Chiang Huang, Kwai-Fong Ng, Kuang-Hua  Chen, Jun‑Te  Hsu, Keng-Hao Liu, Ta-Sen  Yeh, Tse-Ching  Chen

Pages: 530-538 Published online on: 05 June 2014
Article

Fusion of HepG2 cells with mesenchymal stem cells increases cancer‑associated and malignant properties: An in vivo metastasis model

Hong Li, Zhenqing Feng, Tom C. Tsang, Tian  Tang, Xiaoqin  Jia, Xianghui  He, Michael  E. Pennington, Michael  S. Badowski, Anna  K.M. Liu, Deyu  Chen, David  T. Harris, Jesse  Martinez, Linda  C. Meade-Tollin

Pages: 539-547 Published online on: 13 June 2014
Article

A single nucleotide polymorphism in fibronectin 1 determines tumor shape in colorectal cancer

Hiroyuki Kida, Yuki Takano, Ken  Yamamoto, Masaki  Mori, Katsuhiko  Yanaga, Jun-Ichi  Tanaka, Shin-Ei  Kudo, Koshi  Mimori

Pages: 548-552 Published online on: 12 June 2014
Article

The PI3K/mTOR dual inhibitor NVP-BEZ235 reduces the growth of ovarian clear cell carcinoma

Tetsuro Oishi, Hiroaki Itamochi, Akiko Kudoh, Michiko Nonaka, Misaki Kato, Mayumi Nishimura, Nao Oumi, Seiya Sato, Jun Naniwa, Shinya Sato, Muneaki Shimada, Junzo Kigawa, Tasuku Harada

Pages: 553-558 Published online on: 13 June 2014
Article

Blocking PI3K/Akt signaling attenuates metastasis of nasopharyngeal carcinoma cells through induction of mesenchymal-epithelial reverting transition

Hanguo Jiang, Mei Gao, Zhihua Shen, Botao  Luo, Rujia  Li, Xiaofan  Jiang, Ranran  Ding, Yanping  Ha, Zhenliang Wang, Wei  Jie

Pages: 559-566 Published online on: 29 May 2014
Article

Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways

Jia Liu, Lanhong Zheng, Jiateng Zhong, Ning Wu, Ge Liu, Xiukun Lin

Pages: 567-572 Published online on: 06 June 2014
Article

Plasmid-based Stat3-specific siRNA and GRIM-19 inhibit the growth of thyroid cancer cells in vitro and in vivo

Gui-Min Wang, Zhong-Xi Ren, Pei-Song Wang, Chang Su, Wen-Xin Zhang, Zeng-Guang Liu, Ling Zhang, Xue-Jian Zhao, Guang Chen

Pages: 573-580 Published online on: 05 June 2014
Article

Reduced BMP6 expression by DNA methylation contributes to EMT and drug resistance in breast cancer cells

Geng Liu, Yuan-Jie Liu, Wen-Jing Lian, Zhi-Wei Zhao, Tao Yi, Hong-Ying Zhou

Pages: 581-588 Published online on: 29 May 2014
Article

miR-5000-3p, miR-5009-3P and miR-552: Potential microRNA biomarkers of side population cells in colon cancer

Zhong-Sheng Xia, Lin Wang, Tao Yu, Wa Zhong, Guo-Da Lian, Di Wu, Hui-Min Zhou, Guang-Cheng Chen

Pages: 589-596 Published online on: 04 June 2014
Article

Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling

Chi-Cheng Lu, Hao-Ping Chen, Jo-Hua Chiang, Yi-An Jin, Sheng-Chu Kuo, Tian-Shung Wu, Mann-Jen Hour, Jai-Sing Yang, Yu-Jen Chiu

Pages: 597-606 Published online on: 12 June 2014
Article

Overexpression of Tiam1 is associated with malignant phenotypes of nasopharyngeal carcinoma

Yi Ding, Bin Chen, Jing Huang, Wenli Zhang, Hongjun Yang, Yongjian Deng, Jie Lin, Shuang Wang, Xiangmei Zhang

Pages: 607-618 Published online on: 06 June 2014
Article

Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells

Yu-Ying Wan, Jian-Feng Zhang, Zhang-Jian  Yang, Li-Ping  Jiang, Yong‑Fang  Wei, Qi-Nan  Lai, Jian-Bin  Wang, Hong-Bo Xin, Xiao-Jian Han

Pages: 619-626 Published online on: 05 June 2014
Article

A771726, an anti-inflammatory drug, exerts an anticancer effect and reverses tamoxifen resistance in endocrine‑resistant breast cancer cells

Ou Huang, Zuoquan Xie, Weili  Zhang, Ying  Lou, Yan  Mao, Hongchun Liu, Min Jiang, Kunwei Shen

Pages: 627-634 Published online on: 12 June 2014
Article

Effect of brachytherapy on NF-κB and VEGF in gastric carcinoma xenografts

Wan-Fu Zhang, Wen-Di Jin, Bo Li, Ming-Chun Wang, Xiao-Gang Li, Wen-Yuan Mao, Kai-Yuan Luo

Pages: 635-640 Published online on: 12 June 2014
Article

Cancer stem cell differentiation: TGFβ1 and versican may trigger molecules for the organization of tumor spheroids

G.  Oktem, O.  Sercan, U.  Guven, R.  Uslu, A.  Uysal, G.  Goksel, S.  Ayla, A.  Bilir

Pages: 641-649 Published online on: 12 June 2014
Article

Ad-endostatin treatment combined with low-dose irradiation in a murine lung cancer model

Xiao-Peng Li, Hai-Long Zhang, Hui-Juan Wang, Yong-Xia Li, Meng Li, Lian Lu, Yang Wan, Bai-Ling Zhou, Yan Liu, Ying Pan, Xiao-Zhe Wu, Ying-Zi Fan, Chao-Heng Yu, Yu-Quan Wei, Hua-Shan Shi

Pages: 650-658 Published online on: 12 June 2014
Article

The dineolignan from Saururus chinensis, manassantin B, inhibits tumor-induced angiogenesis via downregulation of matrix metalloproteinases 9 in human endothelial cells

Zhaojie Liu, Hong Lu, Rong  Liu, Bin  Chen, Shan  Wang, Junchao  Ma, Jianjiang  Fu

Pages: 659-667 Published online on: 11 June 2014
Article

Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro

Claudia Umbreit, Christoph Aderhold, Anne Faber, Alexander Sauter, Ralf-Dieter Hofheinz, Jens Stern-Straeter, Karl Hoermann, Johannes David Schultz

Pages: 668-676 Published online on: 30 May 2014
Article

CD166 plays a pro-carcinogenic role in liver cancer cells via inhibition of FOXO proteins through AKT

Wenjun Yu, Jiayi Wang, Lifang Ma, Xun Tang, Yongxia Qiao, Quihui Pan, Yongchun Yu, Fenyong Sun

Pages: 677-683 Published online on: 30 May 2014
Article

Establishment of NOD/SCID mouse model of central nervous system leukemia

Dongfang Li, Pinggan Li, Zhanwen He, Zhe Meng, Xiangyang Luo, Jianpei Fang

Pages: 684-690 Published online on: 12 June 2014
Article

Using [18F]FBAU for imaging brain tumor progression in an F98/tk-luc glioma-bearing rat model

Yi-Chun Chien, John Chun-Hao Chen, Wei-Chan Lin, Hueisch-Jy Ding, Hsin-Ell Wang, Chih-Hao K. Kao, Jeng-Jong Hwang

Pages: 691-699 Published online on: 12 June 2014
Article

Characterization of EGFR family gene aberrations in cholangiocarcinoma

Xiaoqing Yang, Weishan Wang, Chunni Wang, Lin Wang, Muyi Yang, Mei Qi, Hong Su, Xiubin Sun, Zhiyan Liu, Juan Zhang, Xiaomin Qin, Bo Han

Pages: 700-708 Published online on: 13 June 2014
Article

In vivo assessment of the vascular disrupting effect of M410 by DCE-MRI biomarker in a rabbit model of liver tumor

Rui-Meng Yang, Yong Zou, Dan-Ping  Huang, Sheng‑Sheng  Lai, Xiang‑Dong Xu, Xin‑Hua  Wei, Han-Zheng Chang, Tong‑Kun  Huang, Li  Wang, Wen-Jie  Tang, Xin-Qing Jiang

Pages: 709-715 Published online on: 04 June 2014
Article

Norcantharidin enhances ABT-263-mediated anticancer activity in neuroblastoma cells by upregulation of Noxa

Xiaohui Wang, Zhimin Gu, Gongquan Li, Shufeng Zhang, Zhenjie Cao, Zhanfeng Yang, Guangzhi Liu

Pages: 716-722 Published online on: 30 May 2014
Article

Hypoxia-targeted triple suicide gene therapy radiosensitizes human colorectal cancer cells

Hung Tsung Hsiao, Ligang Xing, Xuelong Deng, Xiaorong Sun, C. Clifton Ling, Gloria C. Li

Pages: 723-729 Published online on: 06 June 2014
Article

Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma

Pauline J. van der Watt, Widaad Zemanay, Dhirendra Govender, Denver T. Hendricks, M. I. Parker, Virna D. Leaner

Pages: 730-738 Published online on: 04 June 2014
Article

Gene expression profiling of HL-60 cells following knockdown of nucleostemin using DNA microarrays

Xiaoli Sun, Yu Jia, Yuanyu Wei, Shuai Liu, Baohong Yue

Pages: 739-747 Published online on: 06 June 2014
Article

Overexpression of flotillin-1 is involved in proliferation and recurrence of bladder transitional cell carcinoma

Yawei Guan, Haiyan Song, Guohui Zhang, Xing Ai

Pages: 748-754 Published online on: 29 May 2014
Article

Co-expression of CD133, CD44v6 and human tissue factor is associated with metastasis and poor prognosis in pancreatic carcinoma

Kai Chen, Zhonghu Li, Peng Jiang, Xi Zhang, Yujun Zhang, Yan Jiang, Yu He, Xiaowu Li

Pages: 755-763 Published online on: 11 June 2014
Article

shRNA targeting Bmi-1 sensitizes CD44+ nasopharyngeal cancer stem-like cells to radiotherapy

Xin-Hua Xu, Xiao-Yan Liu, Jin Su, Dao-Jun  Li, Qiao  Huang, Ming‑Qian  Lu, Fang  Yi, Jing-Hua  Ren, Wei-Hong Chen

Pages: 764-770 Published online on: 13 June 2014
Article

Wnt5a promotes vasculogenic mimicry and epithelial-mesenchymal transition via protein kinase Cα in epithelial ovarian cancer

Hong Qi, Baocun Sun, Xiulan  Zhao, Jing  Du, Qiang  Gu, Yanrong  Liu, Runfen  Cheng, Xueyi  Dong

Pages: 771-779 Published online on: 04 June 2014
Article

Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency

Yuichi Ohnishi, Yuki Minamino, Kenji  Kakudo, Masami Nozaki

Pages: 780-786 Published online on: 12 June 2014
Article

Modulation of microRNAs by ionizing radiation in human gastric cancer

Jinpeng He, Junrui Hua, Nan Ding, Shuai Xu, Rui Sun, Guangming Zhou, Xiaodong Xie, Jufang Wang

Pages: 787-793 Published online on: 11 June 2014
Article

Chemokine receptor 7 enhances cell chemotaxis and migration of metastatic squamous cell carcinoma of head and neck through activation of matrix metalloproteinase-9

Nan Guo, Fayu Liu, Liangliang Yang, Jinying Huang, Xue Ding, Changfu Sun

Pages: 794-800 Published online on: 06 June 2014
Article

Nuclear expression of p53 in mature tumor endothelium of retinoblastoma

Byung Joo Lee, Jin Hyoung Kim, Dong  Hyun Jo, Kyu‑Won  Kim, Young   Suk Yu, Jeong Hun Kim

Pages: 801-807 Published online on: 05 June 2014
Article

Younger age at the time of first metastasis in BRAF-mutated compared to BRAF wild-type melanoma patients

Melanie Saint-Jean, Gaëlle Quereux, Jean-Michel Nguyen, Lucie Peuvrel, Anabelle Brocard, Audrey Vallee, Anne-Chantal Knol, Amir Khammari, Marc G. Denis, Brigitte Dréno

Pages: 808-814 Published online on: 13 June 2014
Article

Aberrant hypomethylation-mediated AGR2 overexpression induces an aggressive phenotype in ovarian cancer cells

Hye Youn Sung, Eun Nam Choi, Dahyun Lyu, Ae Kyung Park, Woong Ju, Jung-Hyuck Ahn

Pages: 815-820 Published online on: 11 June 2014
Article

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase

Juthika Kundu, Bu Young Choi, Chul-Ho Jeong, Joydeb Kumar Kundu, Kyung-Soo Chun

Pages: 821-828 Published online on: 29 May 2014
Article

Cholangiocarcinoma cell line TK may be useful for the pharmacokinetic study of the chemotherapeutic agent gemcitabine

Minori Kamada, Kohei Akiyoshi, Nobutake Akiyama, Naotake Funamizu, Michiko Watanabe, Kouki Fujioka, Kei-Ichi Ikeda, Yoshinobu Manome

Pages: 829-834 Published online on: 30 May 2014
Article

Minocycline and cisplatin exert synergistic growth suppression on hepatocellular carcinoma by inducing S phase arrest and apoptosis

Fu-Yao Liu, Yan-Hui Wu, Shao-Jun Zhou, Yue-Ling Deng, Zun‑Yi  Zhang, Er-Lei Zhang, Zhi-Yong Huang

Pages: 835-844 Published online on: 12 June 2014
Article

Anchorage-independent growth of Ewing sarcoma cells under serum-free conditions is not associated with stem-cell like phenotype and function

Katharina Leuchte, Bianca Altvater, Simeon  Hoffschlag, Jenny  Potratz, Jutta  Meltzer, Dagmar Clemens, Andrea  Luecke, Jendrik  Hardes, Uta  Dirksen, Heribert  Juergens, Sareetha Kailayangiri, Claudia  Rossig

Pages: 845-852 Published online on: 13 June 2014
Article

Asparagine synthetase expression and its potential prognostic value in patients with NK/T cell lymphoma

Yaqing Li, Xudong Zhang, Tengpeng Hu, Lijuan Han, Ruping Li, Jianguo Wen, Mingzhi Zhang

Pages: 853-859 Published online on: 06 June 2014
Article

Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma

Josephine My Ko, Peng Zhang, Simon Law, Yanhui Fan, You-Qiang Song, Xue Ke Zhao, Elibe H.W. Wong, Sa Tang, Xin Song, Maria Li Lung, Li Dong Wang

Pages: 860-870 Published online on: 29 May 2014
Journal Cover

August-2014
Volume 32 Issue 2

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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