Open Access

Expression of MUC1 in different tumours and its clinical significance (Review)

  • Authors:
    • Yue Lan
    • Weihua Ni
    • Guixiang Tai
  • View Affiliations

  • Published online on: November 1, 2022     https://doi.org/10.3892/mco.2022.2594
  • Article Number: 161
  • Copyright: © Lan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer development, invasion and metastasis. It has been reported that MUC1 upregulation is highly associated with the progression of different epithelial cancer types, such as lung, liver, pancreatic and breast cancer. Therefore, MUC1 can be used as a specific marker and a target for immunotherapy in clinical applications, and the detection of MUC1 expression levels can be used to diagnose the occurrence, metastasis, prognosis and recurrence of cancer. The present review summarizes the abnormal expression of MUC1 in different tumours and discusses its clinical significance, thereby highlighting the potential diagnostic and therapeutic significance of MUC1 in cancer.

Related Articles

Journal Cover

December-2022
Volume 17 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lan Y, Ni W and Tai G: Expression of MUC1 in different tumours and its clinical significance (Review). Mol Clin Oncol 17: 161, 2022
APA
Lan, Y., Ni, W., & Tai, G. (2022). Expression of MUC1 in different tumours and its clinical significance (Review). Molecular and Clinical Oncology, 17, 161. https://doi.org/10.3892/mco.2022.2594
MLA
Lan, Y., Ni, W., Tai, G."Expression of MUC1 in different tumours and its clinical significance (Review)". Molecular and Clinical Oncology 17.6 (2022): 161.
Chicago
Lan, Y., Ni, W., Tai, G."Expression of MUC1 in different tumours and its clinical significance (Review)". Molecular and Clinical Oncology 17, no. 6 (2022): 161. https://doi.org/10.3892/mco.2022.2594