Journal Articles

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Chongyang Ma, Shuling Liu, Shuang Zhang, Tian Xu, Xue Yu, Yushan Gao, Changming Zhai, Changxiang Li, Chaofang Lei, Shuning Fan, Yuxi Chen, Huiling Tian, Qingguo Wang, Fafeng Cheng, Xueqian Wang

Pages: 2979-2990 Published online on: 02 October 2018

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)

Thomas Mbimba, Nazar J. Hussein, Ayesha Najeed, Fayez F. Safadi

Pages: 2991-2997 Published online on: 21 September 2018
Open Access

Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review)

Jorge Reyes‑García, Edgar Flores‑Soto, Abril Carbajal‑García, Bettina Sommer, Luis M. Montaño

Pages: 2998-3008 Published online on: 02 October 2018
Open Access

Suppressive effect of an analog of the antimicrobial peptide of LL‑37 on colon cancer cells via exosome‑encapsulated miRNAs

Miwa Hayashi, Kengo Kuroda, Kohei Ihara, Takahiro Iwaya, Emiko Isogai

Pages: 3009-3016 Published online on: 13 September 2018
Open Access

Silencing of NOD2 protects against diabetic cardiomyopathy in a murine diabetes model

Lin Shen, Li Li, Man Li, Weiling Wang, Wenbin Yin, Wei Liu, Yanyan Hu

Pages: 3017-3026 Published online on: 14 September 2018
Open Access

miR-214 regulates papillary thyroid carcinoma cell proliferation and metastasis by targeting PSMD10

Fangzhou Liu, Kexin Lou, Xiaotong Zhao, Jia Zhang, Wei Chen, Yichun Qian, Yanbin Zhao, Yan Zhu, Yuan Zhang

Pages: 3027-3036 Published online on: 27 September 2018
Open Access

Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice

Joo Wan Kim, You‑Suk Lee, Du Jin Seol, Il Je Cho, Sae Kwang Ku, Jae‑Suk Choi, Hae‑Jeung Lee

Pages: 3047-3064 Published online on: 14 September 2018
Open Access

DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells

Lili Zhang, Shuguang Zhang, Aihua Li, Anqi Zhang, Shiqian Zhang, Liang Chen

Pages: 3065-3072 Published online on: 11 September 2018
Open Access

Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism

Gang Chen, Hugang Shen, Linlin Zang, Zhonglan Su, Jilong Huang, Yong Sun, Hongwei Wang

Pages: 3073-3082 Published online on: 02 October 2018
Open Access

BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo

Yu‑Dong Ji, Zhen‑Long Luo, Chun‑Xiu Chen, Bo Li, Jie Gong, Ya‑Xin Wang, Lin Chen, Shang‑Long Yao, You Shang

Pages: 3083-3092 Published online on: 02 October 2018
Open Access

Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway

Yang Zhou, Tao Hong, Li Tong, Wei Liu, Xueting Yang, Jianghan Luo, Fuling Wang, Jian Li, Lijun Yan

Pages: 3093-3104 Published online on: 07 September 2018
Open Access

A 44-gene set constructed for predicting the prognosis of clear cell renal cell carcinoma

Yonggang Wang, Yao Wang, Feng Liu

Pages: 3105-3114 Published online on: 26 September 2018
Open Access

miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2

Zhen Yang, Rui Li, Jun Ao, Qing‑De Wa, Yi Zhang, Long Chen, Jing Wen, Biao Chen, Wei Pan, Bo Li, Xiao‑Bin Tian

Pages: 3115-3124 Published online on: 21 September 2018
Open Access

Silencing of Annexin A1 suppressed the apoptosis and inflammatory response of preeclampsia rat trophoblasts

Jing Feng, Xinling Wang, Hongyan Li, Li Wang, Zengjun Tang

Pages: 3125-3134 Published online on: 18 September 2018
Open Access

Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway

Xiaoqi Zhang, Hao Feng, Juan Du, Jing Sun, Dongfang Li, Tomoka Hasegawa, Norio Amizuka, Minqi Li

Pages: 3135-3148 Published online on: 17 September 2018
Open Access

(-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity

Tetsu Kawabata, Takanobu Otsuka, Kazuhiko Fujita, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda

Pages: 3149-3156 Published online on: 18 September 2018
Open Access

Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Zhenhui Wu, Yingyu Wang, Xian Meng, Xinjie Wang, Zhenlin Li, Shihui Qian, Yingjie Wei, Luan Shu, Yongfang Ding, Peijuan Wang, Yunru Peng

Pages: 3157-3170 Published online on: 25 September 2018
Open Access

MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1

Yong Yang, Xiao‑Jia Li, Peng Li, Xiu‑Tian Guo

Pages: 3171-3180 Published online on: 01 October 2018
Open Access

Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway

Hao Li, Xiaojuan Li, Xingzhi Jing, Mi Li, Ye Ren, Jingyuan Chen, Caihong Yang, Hua Wu, Fengjing Guo

Pages: 3181-3192 Published online on: 09 October 2018
Open Access

THR1 mediates GCN4 and CDC4 to link morphogenesis with nutrient sensing and the stress response in Candida albicans

Yuan‑Ti Lee, Yi‑Ya Fang, Yu Wen Sun, Hsiao‑Chi Hsu, Shan‑Mei Weng, Tzu‑Ling Tseng, Ting‑Hui Lin, Jia‑Ching Shieh

Pages: 3193-3208 Published online on: 12 October 2018
Open Access

Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway

Wanmin Pei, Yi Zou, Wenting Wang, Lai Wei, Yuan Zhao, Li Li

Pages: 3209-3219 Published online on: 13 September 2018
Open Access

Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation

Su‑Ping Xu, Yong‑Sheng Li

Pages: 3220-3230 Published online on: 01 October 2018
Open Access

Evaluation of the effect of various main elements on the PrPSc detection by real-time quaking-induced conversion assay

Kang Xiao, Qi Shi, Wei Zhou, Chen Gao, Cao Chen, Bao‑Yun Zhang, Jing Wang, Xiao‑Ping Dong

Pages: 3231-3237 Published online on: 07 September 2018
Open Access

Anti-microRNA-132 causes sevoflurane‑induced neuronal apoptosis via the PI3K/AKT/FOXO3a pathway

Ping Dong, Xiyan Zhang, Jian Zhao, Dongliang Li, Liang Li, Bo Yang

Pages: 3238-3246 Published online on: 25 September 2018
Open Access

Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis

Rongrong Li, Youlei Wang, Xiaodong Song, Wenjing Sun, Jinjin Zhang, Yuxia Liu, Hongbo Li, Chao Meng, Jie Zhang, Qingyin Zheng, Changjun Lv

Pages: 3256-3268 Published online on: 24 September 2018
Open Access

Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma

Wassiliki Daskalaki, Eva Wardelmann, Matthias Port, Katharina Stock, Julie Steinestel, Sebastian Huss, Jan Sperveslage, Konrad Steinestel, Stefan Eder

Pages: 3269-3277 Published online on: 25 September 2018
Open Access

O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats

Lin Huang, Ping Yuan, Peng Yu, Qiling Kong, Zixuan Xu, Xia Yan, Yang Shen, Juesheng Yang, Rong Wan, Kui Hong, Yanhua Tang, Jinzhu Hu

Pages: 3278-3290 Published online on: 07 September 2018
Open Access

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Tianzhu Lu, Hongjing Liu, Ganhua You

Pages: 3291-3299 Published online on: 02 October 2018
Open Access

Trifluoperazine prevents FOXO1 nuclear excretion and reverses doxorubicin-resistance in the SHG44/DOX drug-resistant glioma cell line

Xiaozhong Chen, Xiaoquan Luo, Yuan Cheng

Pages: 3300-3308 Published online on: 18 September 2018
Open Access

MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

Chao Li, Zi Wang, Shuangjiang Chen, Jingyao Zhang, Kai Qu, Chang Liu

Pages: 3309-3317 Published online on: 17 September 2018
Open Access

Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions

Zuzana Danková, Dušan Braný, Dana Dvorská, Marcela Ňachajová, Roman Fiolka, Marián Grendár, Jozef Hatok, Peter Kubatka, Veronika Holubeková, Erika Halašová, Tibor Bielik, Pavol Žúbor

Pages: 3318-3328 Published online on: 12 September 2018
Open Access

Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution

Qianwen Ma, Yong Tan, Xuan Chen, Shuping Chen, Yuying Sun, Beibei Zhou

Pages: 3329-3343 Published online on: 13 September 2018
Open Access

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway

Panpan Zhang, Lingyue Hua, Huan Hou, Xingyue Du, Zhiqiang He, Menghan Liu, Xiaojuan Hu, Nianlong Yan

Pages: 3344-3354 Published online on: 19 September 2018
Open Access

Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway

Feibiao Yang, Zhangsheng Xiao, Songze Zhang

Pages: 3355-3363 Published online on: 25 September 2018
Open Access

In vitro analysis of microRNA-26a in chronic lymphocytic leukemia cells

Jing Li, Chang‑Kui Sun

Pages: 3364-3370 Published online on: 10 October 2018
Open Access

Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis

Yongqin Li, Xueyan Zhao, Yujuan Hu, Haiying Sun, Zuhong He, Jie Yuan, Hua Cai, Yu Sun, Xiang Huang, Wen Kong, Weijia Kong

Pages: 3371-3385 Published online on: 01 October 2018
Open Access

Anti-metastatic effect of 131I-labeled Buthus martensii Karsch chlorotoxin in gliomas

Shan Wu, Ke Ma, Wen‑Li Qiao, Ling‑Zhou Zhao, Chang‑Cun Liu, Li‑Lei Guo, Yan Xing, Mei‑Lin Zhu, Jin‑Hua Zhao

Pages: 3386-3394 Published online on: 01 October 2018
Open Access

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma cells via the SMAD2/3 signalling pathway

Zhengzheng Liu, Weilu Kuang, Qin Zhou, Yingying Zhang

Pages: 3395-3403 Published online on: 09 October 2018
Open Access

Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract

Hong‑Ju Liu, Gang Chen, Long Chen, Mei Zhou, Xian‑Zhi Xiong, Zhao‑Ji Meng, Sheng‑Wen Sun, Xiao‑Nan Tao

Pages: 3404-3414 Published online on: 09 October 2018
Open Access

Rosuvastatin reduces the pro-inflammatory effects of adriamycin on the expression of HMGB1 and RAGE in rats

Haiyan Zhang, Xiang Lu, Zhengxia Liu, Kang Du

Pages: 3415-3423 Published online on: 11 October 2018
Open Access

SOSTDC1 inhibits bone metastasis in non-small cell lung cancer and may serve as a clinical therapeutic target

Guanghui Chen, Haiyi Gong, Ting Wang, Jian Wang, Zhitao Han, Guangjian Bai, Shuai Han, Xinghai Yang, Wang Zhou, Tielong Liu, Jianru Xiao

Pages: 3424-3436 Published online on: 10 October 2018

Calcium‑sensing receptors in human peripheral T lymphocytes and AMI: Cause and effect

Jingya Zeng, Ying Pan, Baohong Cui, Taiyu Zhai, Song Gao, Qianyu Zhao, Yihua Sun

Pages: 3437-3446 Published online on: 10 October 2018

In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells

Kaiwen Bai, Luyi Jiang, Ligen Zhang, Yongwei Zhao, Yi Lu, Jingya Zhu, Jie Cai, Lili Zhang, Tian Wang

Pages: 3447-3458 Published online on: 13 September 2018

Hyperosmotic stress stimulates autophagy via the NFAT5/mTOR pathway in cardiomyocytes

Hong Zhu, Wei Cao, Peng Zhao, Jieyu Wang, Yuying Qian, Yun Li

Pages: 3459-3466 Published online on: 12 September 2018

Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells

Yuwei Zhang, Yingquan Luo, Yina Wang, Hong Liu, Yu Yang, Qiong Wang

Pages: 3467-3476 Published online on: 17 September 2018

LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-α, PPAR-γ, STAT‑3, FAS, ACC, perilipin A, and AMPK

Su‑Min Yang, Yu‑Kyoung Park, Jee In Kim, Yun‑Han Lee, Tae‑Yun Lee, Byeong‑Churl Jang

Pages: 3477-3484 Published online on: 21 September 2018

Lithocarpus polystachyus Rehd. leaves aqueous extract protects against hydrogen peroxide‑induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway

Jianmei Gao, Yingshu Xu, Jianyong Zhang, Jingshan Shi, Qihai Gong

Pages: 3485-3494 Published online on: 05 October 2018

Preparation and biological evaluation of a novel pH-sensitive poly (β-malic acid) conjugate for antitumor drug delivery

Youbei Qiao, Bao Liu, Yifan Peng, Erlong Ji, Hong Wu

Pages: 3495-3502 Published online on: 25 September 2018

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Osoro, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun, Shemin Lu

Pages: 3503-3512 Published online on: 25 September 2018

Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis

Qian Zhao, Hui Zhang, Junhua Huang, Huajun Yu, Jiajia Li, Qinfen Che, Yangjie Sun, Yin Jin, Jiansheng Wu

Pages: 3513-3521 Published online on: 09 October 2018

Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia

Pages: 3522-3529 Published online on: 08 October 2018

LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-β/Smad pathway

Xiaohong Wen, Yuan Liu, Yu Bai, Mingwei Li, Qiang Fu, Yi Zheng

Pages: 3530-3541 Published online on: 11 October 2018

Expression and mutations of BRCA in breast cancer and ovarian cancer: Evidence from bioinformatics analyses

Zhu Wang, Jianwen Zhang, Ying Zhang, Qiong Deng, Hui Liang

Pages: 3542-3550 Published online on: 11 September 2018

Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics

Ying Zhou, Ling Li, Jun Qian, Haoyuan Jia, Yubao Cui

Pages: 3551-3561 Published online on: 13 September 2018

miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene

Yuan Yuan, Youwei Zhang, Liang Han, Sanyuan Sun, Yongqian Shu

Pages: 3562-3570 Published online on: 11 September 2018

Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway

Ming Ding, Peng Shu, Shuang Gao, Fenglou Wang, Yitian Gao, Yu Chen, Wenjuan Deng, Gaiying He, Zhenlin Hu, Tianduo Li

Pages: 3571-3581 Published online on: 26 September 2018

Inflammatory stimuli promote oxidative stress in pancreatic acinar cells via Toll-like receptor 4/nuclear factor-κB pathway

Longfei Pan, Lei Yu, Liming Wang, Juntao He, Jiangli Sun, Xiaobo Wang, Hai Wang, Zhenghai Bai, Hui Feng, Honghong Pei

Pages: 3582-3590 Published online on: 01 October 2018

The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells

Jie Liu, Dan Xu, Jingming Li, Ning Gao, Chongbing Liao, Ruihua Jing, Bogang Wu, Bo Ma, Yongping Shao, Cheng Pei

Pages: 3591-3601 Published online on: 02 October 2018

eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration

Zhengrong Xu, Tao Li, Man Li, Lei Yang, Rudan Xiao, Li Liu, Xin Chi, Dianwu Liu

Pages: 3602-3612 Published online on: 26 September 2018

Anemarrhena asphodeloides Bunge ameliorates osteoporosis by suppressing osteoclastogenesis

Jae Sung Lee, Mi Hye Kim, Haesu Lee, Woong Mο Yang

Pages: 3613-3621 Published online on: 01 October 2018

Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process

Xiaoni Zhan, Fengrui Li, Qiaohong Chu, Hao Pang

Pages: 3622-3630 Published online on: 01 October 2018

Repetitive magnetic stimulation promotes the proliferation of neural progenitor cells via modulating the expression of miR-106b

Hua Liu, Gaohua Li, Chunlian Ma, Yanfang Chen, Jinju Wang, Yi Yang

Pages: 3631-3639 Published online on: 09 October 2018
Open Access

[Retracted] Piezo1 protein induces the apoptosis of human osteoarthritis‑derived chondrocytes by activating caspase‑12, the signaling marker of ER stress

Xiao-Fei Li, Zhao Zhang, Zhu-Ke Chen, Zhao-Wei Cui, Hai-Ning Zhang

Pages: 3640-3640 Published online on: 08 October 2018
Journal Cover

December 2018
Volume 42 Issue 6

Print ISSN: 1107-3756
Online ISSN: 1791-244X

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