Journal Articles

Inhibitors targeting the SUMOylation pathway: A patent review 2012‑2015 (Review)

Yanjun Zhou, Chunmei Ji, Mengda Cao, Miao Guo, Wen Huang, Weiwei Ni, Ling Meng, Haiwei Yang, Ji‑Fu Wei

Pages: 3-12 Published online on: 01 November 2017
Open Access

Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation

Hai-Chao Zhang, Zhong-Shuang Zhang, Liang Zhang, Ai Wang, He Zhu, Li Li, Jun-Qiang Si, Xin-Zhi Li, Ke-Tao Ma

Pages: 13-24 Published online on: 20 October 2017
Open Access

Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation

Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang

Pages: 25-32 Published online on: 20 October 2017
Open Access

Atorvastatin protects the proliferative ability of human umbilical vein endothelial cells inhibited by angiotensin II by changing mitochondrial energy metabolism

Ye Chang, Yuan Li, Ning Ye, Xiaofan Guo, Zhao Li, Guozhe Sun, Yingxian Sun

Pages: 33-42 Published online on: 19 October 2017
Open Access

Proliferation of vascular smooth muscle cells under inflammation is regulated by NF-κB p65/microRNA-17/RB pathway activation

Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin

Pages: 43-50 Published online on: 25 October 2017
Open Access

Apolipoprotein C-III in the high-density lipoprotein proteome of cerebral lacunar infarction patients impairs its anti-inflammatory function

Pu Lv, Mingming Zhao, Yuanyuan Liu, Haiqiang Jin, Wei Cui, Chenghe Fan, Yuming Teng, Lemin Zheng, Yining Huang

Pages: 61-68 Published online on: 27 October 2017
Open Access

AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia

Huagang Zhang, Bo Liu, Tianbo Li, Yun Zhu, Guiping Luo, Yunhan Jiang, Fuqin Tang, Zhao Jian, Yingbin Xiao

Pages: 69-76 Published online on: 26 October 2017
Open Access

Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes

Yali Zhang, Mimi Wang, Huanhuan Dong, Xiaomin Yu, Jingfang Zhang

Pages: 77-86 Published online on: 25 October 2017
Open Access

Generation of human-induced pluripotent stem cells from burn patient-derived skin fibroblasts using a non-integrative method

Shangfeng Fu, Jianwu Ding, Dewu Liu, Heping Huang, Min Li, Yang Liu, Longxiang Tu, Deming Liu

Pages: 87-94 Published online on: 23 October 2017
Open Access

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice

Tùng Nguyễn-Thanh, Dal Kim, Sik Lee, Won Kim, Sung Kwang Park, Kyung Pyo Kang

Pages: 95-106 Published online on: 27 October 2017
Open Access

Detection of calprotectin in inflammatory bowel disease: Fecal and serum levels and immunohistochemical localization

Shuhei Fukunaga, Kotaro Kuwaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Hiroshi Yamasaki, Ryosuke Yamauchi, Atsushi Mori, Tatsuyuki Kakuma, Osamu Tsuruta, Takuji Torimura

Pages: 107-118 Published online on: 07 November 2017
Open Access

Radical scavenging-linked anti-adipogenic activity of Alnus firma extracts

Sun-Il Choi, Jong Seok Lee, Sarah Lee, Jin-Ha Lee, Hee-Sun Yang, Joohong Yeo, Jong-Yea Kim, Boo-Yong Lee, Il-Jun Kang, Ok-Hwan Lee

Pages: 119-128 Published online on: 27 October 2017
Open Access

Transforming growth factor β1 promotes migration and invasion in HepG2 cells: Epithelial‑to‑mesenchymal transition via JAK/STAT3 signaling

Xiao‑Long Lin, Mihua Liu, Yuanbo Liu, Huijun Hu, Yongquan  Pan, Weiwen Zou, Xiaojuan Fan, Xuemei Hu

Pages: 129-136 Published online on: 01 November 2017
Open Access

Cryptdin-2 predicts intestinal injury during heatstroke in mice

Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu

Pages: 137-146 Published online on: 01 November 2017
Open Access

Activation of adrenergic receptor β2 promotes tumor progression and epithelial mesenchymal transition in tongue squamous cell carcinoma

Haichao Liu, Cheng Wang, Nan Xie, Zehang Zhuang, Xiqiang Liu, Jinsong Hou, Hongzhang Huang

Pages: 147-154 Published online on: 09 November 2017
Open Access

Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5

Guangru Xu, Hongxing Zhu, Minghui Zhang, Jinhua Xu

Pages: 155-163 Published online on: 31 October 2017
Open Access

YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells

Jie Peng, Hailian Wang, Xin Wang, Minghan Sun, Shaoping Deng, Yi Wang

Pages: 164-172 Published online on: 23 October 2017
Open Access

Synovial fluid‑derived synovial fragments represent an improved source of synovial mesenchymal stem cells in the temporomandibular joint

Yu Yao, Zheng‑Yu Li, Hong Zhang, You‑Hua Zheng, Li‑Xiang Mai, Wen‑Jing Liu, Zhi‑Guang Zhang, Yang‑Peng Sun

Pages: 173-183 Published online on: 25 October 2017
Open Access

Metabolic profiles of adipose-derived and bone marrow-derived stromal cells from elderly coronary heart disease patients by capillary liquid chromatography quadrupole time-of-flight mass spectrometry

Jian-Zhong Li, Hui Qu, Jian Wu, Fan Zhang, Zhi-Bo Jia, Jian-Yong Sun, Bo Lv, Yue Kang, Shu-Lin Jiang, Kai Kang

Pages: 184-194 Published online on: 19 October 2017
Open Access

A novel method of neural differentiation of PC12 cells by using Opti-MEM as a basic induction medium

Rendong Hu, Qiaoyu Cao, Zhongqing Sun, Jinying Chen, Qing Zheng, Fei Xiao

Pages: 195-201 Published online on: 19 October 2017
Open Access

Resveratrol prevents osteoporosis by upregulating FoxO1 transcriptional activity

Yan-Ling Feng, Xiao-Tong Jiang, Fang-Fang Ma, Jie Han, Xu-Lei Tang

Pages: 202-212 Published online on: 23 October 2017
Open Access

Genome-wide DNA methylome alterations in acute coronary syndrome

Dandan Li, Jing Yan, Yunlong Yuan, Cheng Wang, Jia Wu, Qingwen Chen, Jiaxi Song, Junjun Wang

Pages: 220-232 Published online on: 27 October 2017
Open Access

Luteolin inhibits multi-heavy metal mixture-induced HL7702 cell apoptosis through downregulation of ROS-activated mitochondrial pathway

Yafei Wang, Hong Su, Xin Song, Samuel Selorm Fiati Kenston, Jinshun Zhao, Yuanliang Gu

Pages: 233-241 Published online on: 27 October 2017
Open Access

Neuroprotective effects of hydrogen sulfide on sodium azide-induced oxidative stress in PC12 cells

Cheng Gao, Pan Chang, Lijun Yang, Yi Wang, Shaohua Zhu, Haiyan Shan, Mingyang Zhang, Luyang Tao

Pages: 242-250 Published online on: 01 November 2017
Open Access

Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment

Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qin

Pages: 251-263 Published online on: 09 November 2017
Open Access

Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling

Da Hye Kwon, Hee-Jae Cha, Eun Ok Choi, Sun-Hee Leem, Gi-Young Kim, Sung-Kwon Moon, Young-Chae Chang, Seok-Joong Yun, Hye Jin Hwang, Byung Woo Kim, Wun-Jae Kim, Yung Hyun Choi

Pages: 264-274 Published online on: 25 October 2017
Open Access

Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways

Jun Jia, Tracey A. Martin, Lin Ye, Lin Meng, Nan Xia, Wen G. Jiang, Xiaodong Zhang

Pages: 275-283 Published online on: 27 October 2017
Open Access

Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling

Jian-Jun Gu, Kai-Chun Fan, Jian-He Zhang, Hong-Jie Chen, Shou-Sen Wang

Pages: 284-292 Published online on: 02 November 2017
Open Access

Alterations of protein glycosylation in embryonic stem cells during adipogenesis

Wenguang Liu, Xingrong Yan, Wei Liu, Yangyang Wang, Yang Rao, Hanjie Yu, Jihong Cui, Xin Xie, Mei Sun, Lu Yin, Hongmin Li, Fulin Chen

Pages: 293-301 Published online on: 07 November 2017
Open Access

Expression profile analysis of long non-coding RNAs involved in the metformin-inhibited gluconeogenesis of primary mouse hepatocytes

Yao Wang, Hongju Tang, Xueying Ji, Yuqing Zhang, Wan Xu, Xue Yang, Ruyuan Deng, Yun Liu, Fengying Li, Xiao Wang, Libin Zhou

Pages: 302-310 Published online on: 07 November 2017
Open Access

Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development

Ruoxin Wang, Chao Su, Xinting Wang, Qiang Fu, Xingjie Gao, Chunyan Zhang, Jie Yang, Xi Yang, Minxin Wei

Pages: 311-321 Published online on: 03 November 2017
Open Access

Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia

Min Zhao, Shimiao Tang, Junchi Xin, Yingliang Wei, Dongyan Liu

Pages: 322-330 Published online on: 09 November 2017
Open Access

Hey1 functions as a positive regulator of odontogenic differentiation in odontoblast‑lineage cells

Xiao Yin, Zhaobin Zeng, Jinliang Xing, Ansheng Zhang, Wenkai Jiang, Wei Wang, Hantang Sun, Longxing Ni

Pages: 331-339 Published online on: 13 November 2017
Open Access

Broadleaf Mahonia attenuates granulomatous lobular mastitis‑associated inflammation by inhibiting CCL‑5 expression in macrophages

Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin

Pages: 340-352 Published online on: 09 November 2017
Open Access

In vitro investigation of the mechanism underlying the effect of ginsenoside on the proliferation and differentiation of neural stem cells subjected to oxygen-glucose deprivation/reperfusion

Jian Gao, Huajing Bai, Qiang Li, Jian Li, Feng Wan, Mo Tian, Yuanyuan Li, Yilun Song, Jianping Zhang, Yinchu Si

Pages: 353-363 Published online on: 13 November 2017
Open Access

Vitamin D receptor activation influences the ERK pathway and protects against neurological deficits and neuronal death

Jie Yuan, Xin Guo, Zhengang Liu, Xiuqin Zhao, Yan Feng, Sixin Song, Changmeng Cui, Pei Jiang

Pages: 364-372 Published online on: 09 November 2017

Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Senggang-Tang, inhibits TNF-α-induced epithelial-mesenchymal transition in HCT116 colorectal cancer cells

Kangwook Lee, Sung-Gook Cho, Youn Kyung Choi, Yu-Jeong Choi, Gyu-Ri Lee, Chan-Yong Jeon, Seong-Gyu Ko

Pages: 373-380 Published online on: 07 November 2017
Open Access

CCDC134 serves a crucial role in embryonic development

Biaoyi Yu, Tianzhuo Zhang, Peng Xia, Xiaoting Gong, Xiaoyan Qiu, Jing Huang

Pages: 381-390 Published online on: 19 October 2017

Anti-inflammatory effects of a methanolic extract of Castanea seguinii Dode in LPS-induced RAW264.7 macrophage cells

Yourim Lim, Ji-Won Park, Ok-Kyoung Kwon, Jae-Won Lee, Han-Sol Lee, Sangwoo Lee, Sangho Choi, Wanyi Li, Hang Jin, Sang-Bae Han, Kyung-Seop Ahn

Pages: 391-398 Published online on: 27 October 2017

The inhibition of MyD88 and TRIF signaling serve equivalent roles in attenuating myocardial deterioration due to acute severe inflammation

Min-Zhi Ouyang, Dan Zhou, Yun Zhu, Ming Zhang, Ling Li

Pages: 399-408 Published online on: 07 November 2017

Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase/nuclear factor-κB pathway

Xiaozheng Yu, Lijian Cui, Fei Hou, Xiaoya Liu, Yan Wang, Yan Wen, Cheng Chi, Chunyun Li, Ruixia Liu, Chenghong Yin

Pages: 409-420 Published online on: 13 November 2017

Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats

Xueting Li, Jia Yu, Yanping Wu, Baixiang Li

Pages: 421-429 Published online on: 20 October 2017

Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway

Yanting Zou, Lili Ma, Yuan Zhao, Shuncai Zhang, Chaohui Zhou, Yu Cai

Pages: 430-438 Published online on: 19 October 2017

High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1

Yan Lin, Yan Zhao, Enqi Liu

Pages: 439-445 Published online on: 07 November 2017

Mechanism of long non-coding RNA MALAT1 in lipopolysaccharide-induced acute kidney injury is mediated by the miR-146a/NF-κB signaling pathway

Ying Ding, Feng Guo, Tao Zhu, Jun Li, Danyan Gu, Weiliang Jiang, Yuying Lu, Daoyang Zhou

Pages: 446-454 Published online on: 02 November 2017

Persistent STAT5-mediated ROS production and involvement of aberrant p53 apoptotic signaling in the resistance of chronic myeloid leukemia to imatinib

Yanhong Cheng, Yingchan Hao, Aimei Zhang, Chaojie Hu, Xiaoxiao Jiang, Quan Wu, Xiucai Xu

Pages: 455-463 Published online on: 20 October 2017

Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells

Rongmu Xia, Xin Sheng, Xianlin Xu, Chunbo Yu, Hongling Lu

Pages: 464-472 Published online on: 09 November 2017
Open Access

Induced pluripotent stem cell-conditioned medium suppresses pulmonary fibroblast-to-myofibroblast differentiation via the inhibition of TGF-β1/Smad pathway

Yan Zhou, Qiang Zhang, Yuan Gao, Mingqi Tan, Rui Zheng, Li Zhao, Xiaoye Zhang

Pages: 473-484 Published online on: 19 October 2017

Antinociceptive effect of Valeriana fauriei regulates BDNF signaling in an animal model of fibromyalgia

Hwayoung Lee, Jiyun Im, Hansol Won, Jun Young Kim, Hyung‑Ki Kim, Jun‑Tack Kwon, Young Ock Kim, Sanghyun Lee, Ik‑Hyun Cho, Sang Won Lee, Hak‑Jae Kim

Pages: 485-492 Published online on: 20 October 2017

Downregulation of microRNA‑124‑3p suppresses the mTOR signaling pathway by targeting DDIT4 in males with major depressive disorder

Qiuling Wang, Gaofeng Zhao, Zhenzhen Yang, Xia Liu, Ping Xie

Pages: 493-500 Published online on: 06 November 2017

MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1

Yang Zhang, Junying Mou, Li Cao, Su Zhen, Hongjuan Huang, Hongguang Bao

Pages: 501-510 Published online on: 27 October 2017

Protein extracted from Porphyra yezoensis prevents cisplatin-induced nephrotoxicity by downregulating the MAPK and NF-κB pathways

In-Hye Kim, Mi-Jin Kwon, Jae-Hun Jung, Taek-Jeong Nam

Pages: 511-520 Published online on: 26 October 2017

Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells

Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang

Pages: 521-530 Published online on: 27 October 2017

Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability

Arim Lee, Hui Xuan Lim, Myun Soo Kim, Daeho Cho, Kyung Ku Jang, Sang Ho Choi, Tae Sung Kim

Pages: 531-540 Published online on: 01 November 2017

Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells

Lih-Geeng Chen, Yu-Qi Zhang, Zhi-Zhen Wu, Chia-Wen Hsieh, Chi-Shih Chu, Being-Sun Wung

Pages: 541-547 Published online on: 07 November 2017

Low-dose irradiation inhibits proliferation of the p53null type human prostate cancer cells through the ATM/p21 pathway

Si-Jie Li, Xin-Yue Liang, Hai-Jun Li, Guo-Zi Yang, Wei Li, Zhuo Li, Lei Zhou, Xue Wen, De-Hai Yu, Jiu-Wei Cui

Pages: 548-554 Published online on: 07 November 2017

Berberine prevents the apoptosis of mouse podocytes induced by TRAF5 overexpression by suppressing NF-κB activation

Feng Wu, Dong-Sheng Yao, Tian-Ying Lan, Chen Wang, Jian-Dong Gao, Li-Qun He, Di Huang

Pages: 555-563 Published online on: 07 November 2017
Journal Cover

January 2018
Volume 41 Issue 1

Print ISSN: 1107-3756
Online ISSN: 1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
(total number of cites)

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