Journal Articles
Progress of immune checkpoint therapy in the clinic (Review)
Yiqun Fan, Chi Zhang, Shengjie Jin, Zhihui Gao, Jun Cao, Aoqing Wang, Dawei Li, Qian Wang, Xing Sun, Dousheng Bai
Pages: 3-14 Published online on: 24 October 2018
Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer
Huaping Zhou, Allen Chen, Jianfei Shen, Xiaoxue Zhang, Min Hou, Jin Li, Jingyi Chen, Huan Zou, Yingfei Zhang, Qianren Deng, Kelin She, Xiaoshun Shi, Jianxing He
Pages: 15-26 Published online on: 31 October 2018
Antitumor effects of arsenic disulfide on the viability, migratory ability, apoptosis and autophagy of breast cancer cells
Yuxue Zhao, Kenji Onda, Kentaro Sugiyama, Bo Yuan, Sachiko Tanaka, Norio Takagi, Toshihiko Hirano
Pages: 27-42 Published online on: 09 October 2018
PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway
Bo Tang, Wenjin Liang, Yong Liao, Zeming Li, Yan Wang, Chao Yan
Pages: 43-56 Published online on: 25 October 2018
Downregulation of miR‑505‑3p predicts poor bone metastasis‑free survival in prostate cancer
Yubo Tang, Bowen Wu, Shuai Huang, Xinsheng Peng, Xing Li, Xiufang Huang, Wei Zhou, Peigen Xie, Peiheng He
Pages: 57-66 Published online on: 25 October 2018
Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer
Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Pages: 67-76 Published online on: 24 October 2018
Osimertinib (AZD9291) increases radio‑sensitivity in EGFR T790M non‑small cell lung cancer
Nannan Wang, Linlin Wang, Xiangjiao Meng, Jia Wang, Lifang Zhu, Changting Liu, Shaorong Li, Li Zheng, Zhenfan Yang, Ligang Xing, Jinming Yu
Pages: 77-86 Published online on: 17 October 2018
The diagnostic value of circulating microRNAs as a biomarker for gastric cancer: A meta‑analysis
Hui Wei, Ke Pu, Xiao‑Guang Liu, Bo‑Xuan Li, Heng‑Shuo Zhang, Huan Wang, Hao Wang, Wei‑Ming Sun, Yu‑Ping Wang
Pages: 87-102 Published online on: 11 October 2018
Dendritic cell factor 1 inhibits proliferation and migration and induces apoptosis of neuroblastoma cells by inhibiting the ERK signaling pathway
Guanghong Luo, Ruili Feng, Yangyang Sun, Lili Zheng, Yajiang Wang, Yanlu Chen, Tieqiao Wen
Pages: 103-112 Published online on: 16 October 2018
A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma
Jing Guo, Zhuang Wang, Yazhou Miao, Yutao Shen, Mingxuan Li, Lei Gong, Hongyun Wang, Yue He, Hua Gao, Qian Liu, Chuzhong Li, Yazhuo Zhang
Pages: 113-124 Published online on: 02 November 2018
PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells
Peng-Fei Xu, Ji-An Yang, Jun-Hui Liu, Xue Yang, Jian-Ming Liao, Fan-En Yuan, Bao-Hui Liu, Qian-Xue Chen
Pages: 125-132 Published online on: 02 November 2018
Image analysis of the nuclear characteristics of emerin protein and the correlation with nuclear grooves and intranuclear cytoplasmic inclusions in lung adenocarcinoma
Sayaka Kobayashi, Masanao Saio, Toshio Fukuda, Kiminori Kimura, Junko Hirato, Tetsunari Oyama
Pages: 133-142 Published online on: 02 November 2018
Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation
Jingling Jin, Junliang Jin, Sarah E. Woodfield, Roma H. Patel, Nan Ge Jin, Yan Shi, Bin Liu, Wenjing Sun, Xiangmei Chen, Yang Yu, Sanjeev A. Vasudevan
Pages: 143-153 Published online on: 15 October 2018
High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma
Qingyan Zhang, Danhui Huang, Zhenfei Zhang, Yuzhen Feng, Meiting Fu, Min Wei, Jueyu Zhou, Yuanjin Huang, Shuguang Liu, Rong Shi
Pages: 154-164 Published online on: 12 October 2018
RGS5 decreases the proliferation of human ovarian carcinoma‑derived primary endothelial cells through the MAPK/ERK signaling pathway in hypoxia
Dan Wang, Yan Xu, Lu Feng, Pin Yin, Shuang Shuang Song, Feng Wu, Ping Yan, Zhiqing Liang
Pages: 165-177 Published online on: 22 October 2018
Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation
Jesús Valencia‑Cervantes, Sara Huerta‑Yepez, Guillermo Aquino‑Jarquín, Sara Rodríguez‑Enríquez, Daniel Martínez‑Fong, José‑Antonio Arias‑Montaño, Víctor Manuel Dávila‑Borja
Pages: 178-190 Published online on: 12 October 2018
GLIS2 redundancy causes chemoresistance and poor prognosis of gastric cancer based on co‑expression network analysis
Jingsheng Yuan, Lulu Tan, Zhijie Yin, Kaixiong Tao, Guobing Wang, Wenjia Shi, Jinbo Gao
Pages: 191-201 Published online on: 15 October 2018
Galla Rhois water extract inhibits lung metastasis by inducing AMPK‑mediated apoptosis and suppressing metastatic properties of colorectal cancer cells
Jeong‑Geon Mun, Ji‑Ye Kee, Yo‑Han Han, Sullim Lee, Seong‑Hwan Park, Hee Dong Jeon, Seung‑Heon Hong
Pages: 202-212 Published online on: 22 October 2018
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway
Huan Yu, Qi‑Rui Fu, Zhi‑Jie Huang, Jia‑Yu Lin, Qing‑Xi Chen, Qin Wang, Dong‑Yan Shen
Pages: 213-223 Published online on: 29 October 2018
sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling
Ji‑Xiang Peng, Shun‑Yu Liang, Li Li
Pages: 224-234 Published online on: 31 October 2018
Anoikis‑resistant human osteosarcoma cells display significant angiogenesis by activating the Src kinase‑mediated MAPK pathway
Ziran Gao, Guo‑Sheng Zhao, Yangfan Lv, Dongbin Peng, Xuefeng Tang, Hanxiang Song, Qiao‑Nan Guo
Pages: 235-245 Published online on: 29 October 2018
Bromodomain PHD‑finger transcription factor promotes glioma progression and indicates poor prognosis
Yanling Pan, Feng Yuan, Yijie Li, Guoping Wang, Zhiren Lin, Longhua Chen
Pages: 246-256 Published online on: 30 October 2018
Exosomal microRNAs as potential biomarkers for cancer cell migration and prognosis in hepatocellular carcinoma patient-derived cell models
Ling-Xiang Yu, Bo-Lun Zhang, Yuan Yang, Meng-Chao Wang, Guang-Lin Lei, Yuan Gao, Hu Liu, Chao-Hui Xiao, Jia-Jia Xu, Hao Qin, Xiao-Ya Xu, Zi-Shuo Chen, Da-Dong Zhang, Fu-Gen Li, Shao-Geng Zhang, Rong Liu
Pages: 257-269 Published online on: 29 October 2018
Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway
Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang
Pages: 270-278 Published online on: 02 November 2018
Identifying the key genes and microRNAs in colorectal cancer liver metastasis by bioinformatics analysis and in vitro experiments
Tao Zhang, Jianrong Guo, Jian Gu, Zheng Wang, Guobin Wang, Huili Li, Jiliang Wang
Pages: 279-291 Published online on: 01 November 2018
Identification of a 5‑microRNA signature and hub miRNA‑mRNA interactions associated with pancreatic cancer
Xianxiong Ma, Ruikang Tao, Lei Li, Hengyu Chen, Zongtao Liu, Jie Bai, Xiaoming Shuai, Chuanqing Wu, Kaixiong Tao
Pages: 292-300 Published online on: 24 October 2018
Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis
Junji Akagi, Hideo Baba
Pages: 301-311 Published online on: 01 November 2018
Peptides and small molecules blocking the CXCR4/CXCL12 axis overcome bone marrow‑induced chemoresistance in acute leukemias
Serena Pillozzi, Andrea Bernini, Ottavia Spiga, Barbara Lelli, Giulia Petroni, Luisa Bracci, Neri Niccolai, Annarosa Arcangeli
Pages: 312-324 Published online on: 18 October 2018
Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma
Lianhua Piao, Xiaofeng Yuan, Ming Zhuang, Xubin Qiu, Xiaoshuang Xu, Ren Kong, Zhiwei Liu
Pages: 325-332 Published online on: 01 November 2018
Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3
Su‑Hyun Nho, Goo Yoon, Ji‑Hye Seo, Ha‑Na Oh, Seung‑Sik Cho, Hangun Kim, Hyun Woo Choi, Jung‑Hyun Shim, Jung‑Il Chae
Pages: 333-340 Published online on: 11 October 2018
β‑blockers inhibit the viability of breast cancer cells by regulating the ERK/COX‑2 signaling pathway and the drug response is affected by ADRB2 single‑nucleotide polymorphisms
Wan‑Ying Xie, Ruo‑Hui He, Jun Zhang, Yi‑Jing He, Zan Wan, Cheng‑Fang Zhou, Yong‑Jun Tang, Zhi Li, Howard L. Mcleod, Jie Liu
Pages: 341-350 Published online on: 29 October 2018
MicroRNA‑494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression
Kun Han, Zhao Jian Li, Peng Sun
Pages: 351-360 Published online on: 25 October 2018
Malignant gliomas can be converted to non‑proliferating glial cells by treatment with a combination of small molecules
Jinsoo Oh, Yongbo Kim, Daye Baek, Yoon Ha
Pages: 361-368 Published online on: 25 October 2018
Ginkgolic acid suppresses the invasion of HepG2 cells via downregulation of HGF/c‑Met signaling
Hua Li, Xiaofen Meng, Di Zhang, Xin Xu, Shunle Li, Yiming Li
Pages: 369-376 Published online on: 12 October 2018
miR‑101 regulates the cell proliferation and apoptosis in diffuse large B‑cell lymphoma by targeting MEK1 via regulation of the ERK/MAPK signaling pathway
Yiqun Huang, Yong Zou, Luhui Lin, Xudong Ma, Ruiji Zheng
Pages: 377-386 Published online on: 24 October 2018
Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells
Lennard Schröder, Philip Marahrens, Julian G. Koch, Helene Heidegger, Theresa Vilsmeier, Thuy Phan-Brehm, Simone Hofmann, Sven Mahner, Udo Jeschke, Dagmar U. Richter
Pages: 387-396 Published online on: 12 October 2018
Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma
Lin Zhuang, Jie Lai, Kun Chen, Tianling Ding, Yan Yuan, Yan Ma, Hui Kang, Zhiguang Lin, Ni Fan, Jingjing Ma, Qingchao Zeng, Xiaoping Xu, Qingping Wang, Bobin Chen
Pages: 397-404 Published online on: 11 October 2018
Metformin suppresses gastric cancer progression through calmodulin‑like protein 3 secreted from tumor‑associated fibroblasts
Guangxia Chen, Chenxiao Yu, Zhicheng Tang, Shiyu Liu, Fangmei An, Junjia Zhu, Qianqian Wu, Jianping Cao, Qiang Zhan, Shuyu Zhang
Pages: 405-414 Published online on: 11 October 2018
Mechanisms underlying the increased chemosensitivity of bortezomib-resistant multiple myeloma by silencing nuclear transcription factor Snail1
Zhenqi Huang, Xinglin Liang, Wei Wu, Xiaowen Chen, Qingshu Zeng, Mingzhen Yang, Jian Ge, Ruixiang Xia
Pages: 415-426 Published online on: 16 October 2018
I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3
Lupeng Wang, Haimei Shi, Xiaoyu Zhang, Xiuli Zhang, Ya Liu, Wenyi Kang, Xiaoyan Shi, Tianxiao Wang
Pages: 427-436 Published online on: 16 October 2018
Signaling pathway inhibitors target breast cancer stem cells in triple-negative breast cancer
Wenlong Li, Hongmei Yang, Xiaoli Li, Lou Han, Ning Xu, Aiping Shi
Pages: 437-446 Published online on: 18 October 2018
Non‑invasive monitoring of cisplatin and erlotinib efficacy against lung cancer in orthotopic SCID mouse models by small animal FDG‑PET/CT and CT
Tamaki Otani, Kazuya Kondo, Hiromitsu Takizawa, Koichiro Kajiura, Haruhiko Fujino, Hideki Otsuka, Hirokazu Miyoshi
Pages: 447-454 Published online on: 24 October 2018
Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression
Lei Zhu, Xiao‑Xia Li, Liang Shi, Jing Wu, Jia‑Yi Qian, Tian‑Song Xia, Wen‑Bin Zhou, Xi Sun, Xu‑Jie Zhou, Ji‑Fu Wei, Qiang Ding
Pages: 455-464 Published online on: 01 November 2018
Fascin is involved in cancer cell invasion and is regulated by stromal factors
Xianglan Zhang, Il‑Hoon Cho, Ji Hyeon Park, Min Kyeong Lee, Young Sun Hwang
Pages: 465-474 Published online on: 02 November 2018
Induction of apoptosis and erythroid differentiation of human chronic myelogenous leukemia K562 cells by low concentrations of lidamycin
Chu Zhang, Lu-Ying Guo, Dan Mu, Jian-Hua Gong, Jing Chen
Pages: 475-482 Published online on: 02 November 2018
Long non‑coding RNA ENST00000547547 inhibits cell proliferation, invasion and migration in colorectal cancer cells
Xiaohui Ai, Qingliang Lei, Xiaoping Shen, Jian Li, Chaoqun Cen, Gang Xie, Bo Luo, Wenshuo Zhu, Gui Hu, Hao Wu, Miao Chen, Xiaorong Li, Changwei Lin
Pages: 483-491 Published online on: 31 October 2018
Inhibition of autophagy enhances cinobufagin‑induced apoptosis in gastric cancer
Xuanxuan Xiong, Bo Lu, Qingzhong Tian, Haiyan Zhang, Mingbo Wu, Hao Guo, Qianjin Zhang, Xiangcheng Li, Tian Zhou, Yun Wang
Pages: 492-500 Published online on: 31 October 2018
In vitro neutralization of autocrine IL‑10 affects Op18/stathmin signaling in non‑small cell lung cancer cells
Yan Zhao, Sangyan Chen, Fang Shen, Dan Long, Ting Yu, Mengru Wu, Xuechi Lin
Pages: 501-511 Published online on: 15 October 2018
Two prostate cancer‑associated polymorphisms in the 3'UTR of IGF1R influences prostate cancer susceptibility by affecting miRNA binding
Huimin Wang, Wentao Huang, Xiaoxiang Yu, Weidong Li, Yuanjie Huang, Zengnan Mo, Yong Gao, Qingniao Zhou, Yanling Hu
Pages: 512-524 Published online on: 22 October 2018
Vorinostat enhances gefitinib‑induced cell death through reactive oxygen species‑dependent cleavage of HSP90 and its clients in non‑small cell lung cancer with the EGFR mutation
Sang Eun Park, Dong Eun Kim, Mi Joung Kim, Jee Suk Lee, Jin Kyung Rho, Seong‑Yun Jeong, Eun Kyung Choi, Choung‑Soo Kim, Jung Jin Hwang
Pages: 525-533 Published online on: 22 October 2018
Affibody‑mediated imaging of EGFR expression in prostate cancer using radiocobalt‑labeled DOTA‑ZEGFR:2377
Bogdan Mitran, Ken Gösta Andersson, Elin Lindström, Javad Garousi, Maria Rosestedt, Vladimir Tolmachev, Stefan Ståhl, Anna Orlova, John Löfblom
Pages: 534-542 Published online on: 15 October 2018
Ubiquitin‑specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial‑mesenchymal transition
Qiuming Zeng, Zongyuan Li, Xi Zhao, Liang Guo, Chao Yu, Jun Qin, Shiqiong Zhang, Yongle Zhang, Xuhui Yang
Pages: 543-551 Published online on: 31 October 2018
BRMS1 participates in regulating cell sensitivity to DNA interstrand crosslink damage by interacting with FANCI
Jianming Dou, Yiren Zhou, Xuni Liu, Xiaojing Qiao, Xi Yang, Wenjuan Xie, Shouyi Qiao, Yanhua Wu
Pages: 552-558 Published online on: 24 October 2018
Downregulation of cyclooxygenase‑1 stimulates mitochondrial apoptosis through the NF‑κB signaling pathway in colorectal cancer cells
Lei Ding, Huan Gu, Zhenwei Lan, Qingchun Lei, Wenxue Wang, Jiangfei Ruan, Min Yu, Jie Lin, Qinghua Cui
Pages: 559-569 Published online on: 12 October 2018
E26 transformation (ETS)‑specific related transcription factor‑3 (ELF3) orchestrates a positive feedback loop that constitutively activates the MAPK/Erk pathway to drive thyroid cancer
Heming Chen, Weihong Chen, Xiaojun Zhang, Lin Hu, Guojun Tang, Juan Kong, Zhiwei Wang
Pages: 570-578 Published online on: 18 October 2018
SND1 promotes the proliferation of osteosarcoma cells by upregulating COX‑2/PGE2 expression via activation of NF‑κB
Ming Zhou, Aman Wang, Baosheng Yin, Dan Wu, Shiliang Han, Wenpeng Zhang, Jiwei Liu, Kang Sun
Pages: 579-589 Published online on: 24 October 2018
Phosphorylation of nucleolin is indispensable to its involvement in the proliferation and migration of non-small cell lung cancer cells
Feifei Huang, Yanyang Wu, Hong Tan, Tianyao Guo, Ke Zhang, Daiqiang Li, Zhongyi Tong
Pages: 590-598 Published online on: 12 October 2018
MicroRNA‑301a targets WNT1 to suppress cell proliferation and migration and enhance radiosensitivity in esophageal cancer cells
Huafang Su, Youyi Wu, Ya Fang, Lanxiao Shen, Zhenghua Fei, Congying Xie, Ming Chen
Pages: 599-607 Published online on: 16 October 2018
CCL9/CCR1 induces myeloid‑derived suppressor cell recruitment to the spleen in a murine H22 orthotopic hepatoma model
Baohua Li, Shu Zhang, Na Huang, Haiyan Chen, Peijun Wang, Jun Yang, Zongfang Li
Pages: 608-618 Published online on: 18 October 2018
MicroRNA-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting ARRB1-mediated AKT activation
Zhe Zhang, Xiaohua Zhong, Yipin Xiao, Chao Chen
Pages: 619-629 Published online on: 18 October 2018
COL‑3 enhances the anti‑proliferative and pro‑apoptotic effects of paclitaxel in breast cancer cells
Roba M. El‑Tabba', Princy Mathew, Willias Masocha, Maitham A. Khajah
Pages: 630-642 Published online on: 22 October 2018
OBP‑801, a novel histone deacetylase inhibitor, induces M‑phase arrest and apoptosis in rhabdomyosarcoma cells
Chihiro Tomoyasu, Ken Kikuchi, Daisuke Kaneda, Shigeki Yagyu, Mitsuru Miyachi, Kunihiko Tsuchiya, Tomoko Iehara, Toshiyuki Sakai, Hajime Hosoi
Pages: 643-649 Published online on: 22 October 2018
Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways
Wei Li, Zheng Wang, Xue Xiao, Liang Han, Zheng Wu, Qingyong Ma, Lei Cao
Pages: 650-658 Published online on: 30 October 2018
Identification of biomarkers for the prediction of relapse‑free survival in pediatric B‑precursor acute lymphoblastic leukemia
Wei Jing, Jing Li
Pages: 659-667 Published online on: 02 November 2018
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway
Wei Wang, Han Du, Huiping Liu, Fangfang Hu, Guangzhi Liu
Pages: 668-676 Published online on: 31 October 2018
Inhibitory effects of Schisandrin B on human prostate cancer cells
Moussa Ide Nasser, Tingyu Han, Salah Adlat, Yuxin Tian, Nan Jiang
Pages: 677-685 Published online on: 15 October 2018
Oncolytic cancer therapy with a vaccinia virus strain
Lili Deng, Jun Fan, Yuedi Ding, Jue Zhang, Bin Zhou, Yi Zhang, Biao Huang, Zhigang Hu
Pages: 686-692 Published online on: 16 October 2018
Novel 2,3‑disubstituted 1,3‑thiazolidin‑4‑one derivatives as potential antitumor agents in renal cell adenocarcinoma
Monika Gawrońska‑Grzywacz, Łukasz Popiołek, Dorota Natorska‑Chomicka, Iwona Piątkowska‑Chmiel, Magdalena Izdebska, Mariola Herbet, Magdalena Iwan, Agnieszka Korga, Jarosław Dudka, Monika Wujec
Pages: 693-701 Published online on: 16 October 2018
MicroRNA‑876‑5p inhibits the progression of glioblastoma multiforme by directly targeting Forkhead box M1
Lina Wang, Jia Lu, Hong Zhang, Xueman Lyu, Zhigang Sun
Pages: 702-710 Published online on: 17 October 2018
Anticancer activity of gomisin J from Schisandra chinensis fruit
Samil Jung, Hyung-In Moon, Subeen Kim, Nguyen Thi Ngoc Quynh, Jimin Yu, Zolzaya Sandag, Dan-Diem Thi Le, Hyegyeong Lee, Hyojeong Lee, Myeong-Sok Lee
Pages: 711-717 Published online on: 02 November 2018
[Corrigendum] Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKT inhibitor MK2206 in mammary cancer models
Ronald A. Lubet, Vernon E. Steele, M. M. Juliana, Ann Bode, Fariba Moeinpour, Clinton J. Grubbs
Pages: 718-718 Published online on: 17 October 2018
