Journal Articles

Epigenetic roles of PIWI‑interacting RNAs (piRNAs) in cancer metastasis (Review)

Jia Liu, Shujun Zhang, Binglin Cheng

Pages: 2423-2434 Published online on: 06 September 2018
Open Access

3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu

Pages: 2435-2444 Published online on: 14 August 2018
Open Access

CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells

Fengbin Gao, Xiaojing Wang, Shanwen Chen, Tianyuan Xu, Xianjin Wang, Yifan Shen, Fan Dong, Shan Zhong, Zhoujun Shen

Pages: 2445-2454 Published online on: 10 August 2018

Generation of PTEN‑knockout (‑/‑) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling

Akiko Takao, Kazuhiro Yoshikawa, Sivasundaram Karnan, Akinobu Ota, Hirotsugu Uemura, Marco A. De Velasco, Yurie Kura, Susumu Suzuki, Ryuzo Ueda, Tokiko Nishino, Yoshitaka Hosokawa

Pages: 2455-2466 Published online on: 05 September 2018
Open Access

Risk assessment model constructed by differentially expressed lncRNAs for the prognosis of glioma

Chenggong Hu, Yongfang Zhou, Chang Liu, Yan Kang

Pages: 2467-2476 Published online on: 10 August 2018
Open Access

Knockdown of POLE2 expression suppresses lung adenocarcinoma cell malignant phenotypes in vitro

Jianying Li, Juanhong Wang, Jun Yu, Yuling Zhao, Ya Dong, Yali Fan, Namiao Li, Yingying Zhang, Yili Wang

Pages: 2477-2486 Published online on: 17 August 2018
Open Access

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma

Yoshimasa Sumita, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Jun‑Ichi Tanuma

Pages: 2487-2496 Published online on: 22 August 2018
Open Access

UCA1 overexpression is associated with less aggressive subtypes of bladder cancer

Laetitia Lebrun, Dina Milowich, Marie Le Mercier, Justine Allard, Yves‑Rémi Van Eycke, Thierry Roumeguere, Christine Decaestecker, Isabelle Salmon, Sandrine Rorive

Pages: 2497-2506 Published online on: 10 September 2018
Open Access

lncRNA LINC01296 regulates the proliferation, metastasis and cell cycle of osteosarcoma through cyclin D1

Xin Yu, Lei Pang, Teng Yang, Pengcheng Liu

Pages: 2507-2514 Published online on: 30 August 2018
Open Access

The role of 17β‑estradiol‑induced upregulation of Piwi‑like 4 in modulating gene expression and motility in breast cancer cells

Zealyn Shi Lin Heng, Jing Yi Lee, Charannya Sozheesvari Subhramanyam, Cheng Wang, Lal Zo Thanga, Qidong Hu

Pages: 2525-2535 Published online on: 31 August 2018
Open Access

hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis

Bojin Su, Tao Xu, Jeff P. Bruce, Kenneth W. Yip, Ning Zhang, Zeli Huang, Guoyi Zhang, Fei‑Fei Liu, Jiyong Liang, Huiling Yang, François X. Claret

Pages: 2536-2546 Published online on: 07 September 2018
Open Access

CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma

Quan Liu, Dahua Fan, Dickson Adah, Zhengzhi Wu, Renyan Liu, Qiao‑Ting Yan, Yue Zhang, Zhi‑Yong Du, Dou Wang, Yan Li, Shi‑Yun Bao, Li‑Ping Liu

Pages: 2547-2557 Published online on: 23 August 2018
Open Access

Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma

Lu Gao, Wei Zhang, Wen‑Qun Zhong, Zhuo‑Jue Liu, Hui‑Min Li, Zi‑Li Yu, Yi‑Fang Zhao

Pages: 2558-2572 Published online on: 17 August 2018
Open Access

HOXA10‑AS: A novel oncogenic long non‑coding RNA in glioma

Cheng‑Ya Dong, Jiayue Cui, Dian‑He Li, Qi Li, Xin‑Yu Hong

Pages: 2573-2583 Published online on: 21 August 2018
Open Access

Characterization of selective exosomal microRNA expression profile derived from laryngeal squamous cell carcinoma detected by next generation sequencing

Qiang Huang, Jiechao Yang, Juan Zheng, Chiyao Hsueh, Yang Guo, Liang Zhou

Pages: 2584-2594 Published online on: 24 August 2018
Open Access

Interaction of hematopoietic CD34+ CD45+ stem cells and cancer cells stimulated by TGF‑β1 in a model of glioblastoma in vitro

Elena Milkina, Arina Ponomarenko, Maria Korneyko, Irina Lyakhova, Yulia Zayats, Sergey Zaitsev, Polina Mischenko, Marina Eliseikina, Yuri Khotimchenko, Valeryi Shevchenko, Hari Sharma, Igor Bryukhovetskiy

Pages: 2595-2607 Published online on: 24 August 2018
Open Access

KLF5 promotes the tumorigenesis and metastatic potential of thyroid cancer cells through the NF-κB signaling pathway

Yuehua Ma, Qingzhu Wang, Fei Liu, Xiaojun Ma, Lina Wu, Feng Guo, Shuiying Zhao, Fengjuan Huang, Guijun Qin

Pages: 2608-2618 Published online on: 06 September 2018
Open Access

STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2

Sirichat Kaowinn, Chutima Kaewpiboon, Sang Seok Koh, Oliver H. Krämer, Young‑Hwa Chung

Pages: 2619-2627 Published online on: 12 September 2018
Open Access

Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma

Dong Wang, Ruizhi Wang, Anpei Huang, Zeng Fang, Kebing Wang, Meifang He, Jin‑Tang Xia, Wen Li

Pages: 2628-2636 Published online on: 12 September 2018
Open Access

An integrated methylation and gene expression microarray analysis reveals significant prognostic biomarkers in oral squamous cell carcinoma

Chenguang Zhao, Huiru Zou, Jun Zhang, Jinhui Wang, Hao Liu

Pages: 2637-2647 Published online on: 12 September 2018
Open Access

Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer

Yeshuo Ma, Yifei Chen, Changwei Lin, Gui Hu

Pages: 2648-2658 Published online on: 10 September 2018
Open Access

Prediction of candidate RNA signatures for recurrent ovarian cancer prognosis by the construction of an integrated competing endogenous RNA network

Xin Wang, Lei Han, Ling Zhou, Li Wang, Lan‑Mei Zhang

Pages: 2659-2673 Published online on: 13 September 2018

Regulatory mechanism of fatty acid‑CoA metabolic enzymes under endoplasmic reticulum stress in lung cancer

Kuan‑Ting Liu, I‑Jeng Yeh, Shih‑Kai Chou, Meng‑Chi Yen, Po‑Lin Kuo

Pages: 2674-2682 Published online on: 21 August 2018

MALAT1 promotes angiogenesis of breast cancer

Xiao‑Juan Huang, Yu Xia, Gui‑Fang He, Lu‑Lu Zheng, Yong‑Ping Cai, Yu Yin, Qiang Wu

Pages: 2683-2689 Published online on: 13 September 2018

EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR‑positive cancer cells

Saeed M. Hashimi, Brock Grant, Naif Alqurashi, Faisal Alowaidi, Ming Q. Wei

Pages: 2690-2697 Published online on: 06 September 2018

Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma

Wenwen Lv, Xiao Yu, Wenxing Li, Nannan Feng, Tienan Feng, Yu Wang, Hongyan Lin, Biyun Qian

Pages: 2698-2709 Published online on: 14 August 2018

miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3

Na Zhou, Zhao Sun, Ningning Li, Yuping Ge, Jianfeng Zhou, Qin Han, Lin Zhao, Chunmei Bai

Pages: 2710-2721 Published online on: 10 August 2018

B7‑H3 promotes malignant progression of muscle‑invasive bladder cancer

Zhi‑Li Xu, Yi Zhang, Ling Wang, Feng Li, Hong‑Wei Man, Peng‑Fei Li, Bao‑En Shan

Pages: 2722-2733 Published online on: 17 August 2018

C‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer

Huijin Li, Hui Li, Xiao‑Peng Li, Haojun Zou, Liting Liu, Wangqiao Liu, Tao Duan

Pages: 2734-2741 Published online on: 17 August 2018

APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance

Christina Schmitt, Ralph Lucius, Michael Synowitz, Janka Held‑Feindt, Kirsten Hattermann

Pages: 2742-2749 Published online on: 10 September 2018

MicroRNA‑342‑3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42

Lu Shi, Ruowen Xiao, Menghe Wang, Meiyin Zhang, Nuoqing Weng, Xinge Zhao, X.f. Steven Zheng, Huiyun Wang, Shijuan Mai

Pages: 2750-2757 Published online on: 10 August 2018

Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals

Pei‑Jing Yang, Ming‑Feng Hou, Eing‑Mei Tsai, Shih‑Shin Liang, Chien‑Chih Chiu, Fu Ou‑Yang, Jung‑Yu Kan, Chiung‑Yu Peng, Tsu‑Nai Wang

Pages: 2766-2777 Published online on: 30 August 2018

Low expression of BEX1 predicts poor prognosis in patients with esophageal squamous cell cancer

Hai‑Tao Geng, Zhi‑Wen Cheng, Rui‑Juan Cao, Zhen‑Bo Wang, Shao‑Zhi Xing, Chen Guo, Feng Wang, Chang‑Min Liu, Shao‑Shui Chen, Yu‑Feng Cheng

Pages: 2778-2787 Published online on: 17 August 2018

Lactate dehydrogenase is correlated with clinical stage and grade and is downregulated by si‑SAΤB1 in ovarian cancer

Jiangdong Xiang, Lina Zhou, Yan Zhuang, Jin Zhang, Ya Sun, Shuangdi Li, Zhenbo Zhang, Gao Zhang, Yinyan He

Pages: 2788-2797 Published online on: 17 August 2018

Inhibition of miR‑21 promotes cell apoptosis in oral squamous cell carcinoma by upregulating PTEN

Yanliang Zheng, Jingfang Xie, Fangfang Jiang, Yunyun Li, Guanlin Chang, Haiqing Ma

Pages: 2798-2805 Published online on: 21 August 2018

miR‑20b negatively regulates VEGF expression by targeting STAT3 in H22 hepatocellular carcinoma cells

Yulan Luo, Jing He, Xiangnan Tao, Helong Wang, Qiang Fang, Shujun Guo, Chuanwang Song

Pages: 2806-2813 Published online on: 17 August 2018

Long non-coding RNA MYU promotes prostate cancer proliferation by mediating the miR-184/c-Myc axis

Jinhua Wang, Xiaohui Yang, Rong Li, Liang Wang, Yinmin Gu, Yuhui Zhao, Kuo Hsiang Huang, Tianyou Cheng, Yi Yuan, Shan Gao

Pages: 2814-2825 Published online on: 20 August 2018

A novel clinical multidimensional transcriptome signature predicts prognosis in bladder cancer

Chun‑Peng Liu, Jian‑Hua Zhang, Shuai‑Chao Zheng, Jing Liu, Jin‑Cheng Guo

Pages: 2826-2835 Published online on: 31 August 2018

2'‑Hydroxyflavanone inhibits epithelial‑mesenchymal transition, and cell migration and invasion via suppression of the Wnt/β‑catenin signaling pathway in prostate cancer

Shiqi Wu, Jun Huang, Ke Hui, Yangyang Yue, Yanan Gu, Zhongyun Ning, Xinyang Wang, Dalin He, Kaijie Wu

Pages: 2836-2843 Published online on: 31 August 2018

Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression

Wei‑Sheng Xiao, De‑Feng Li, Ya‑Ping Tang, Yan‑Zhu Chen, Wen‑Bing Deng, Juan Chen, Wei‑Wei Zhou, Ai‑Jun Liao

Pages: 2844-2853 Published online on: 04 September 2018

Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer

Jianfeng Zhang, Weifeng Ding, Xiaoling Kuai, Yimin Ji, Zhenglong Zhu, Zhenbiao Mao, Zhiwei Wang

Pages: 2854-2863 Published online on: 24 August 2018

Effects of microRNA‑125b on multiple myeloma cell growth in vitro and in vivo

Yanxia Jiang, Jianghua Ding, Jing Li, Guoan Chen

Pages: 2864-2875 Published online on: 23 August 2018

TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway

Jiyi Zhao, Ling Gai, Yi Gao, Wenkai Xia, Dong Shen, Qingfeng Lin, Weidong Mao, Fangjun Wang, Pengfei Liu, Jie Chen

Pages: 2876-2885 Published online on: 06 September 2018

Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response

Dan Zhang, Yiping Dong, Ying Zhao, Congya Zhou, Yuanjie Qian, Muralidhar L. Hegde, Haibo Wang, Suxia Han

Pages: 2886-2895 Published online on: 10 September 2018

18F‑alfatide positron emission tomography may predict anti‑angiogenic responses

Jie Liu, Dongxu Wang, Xue Meng, Xindong Sun, Shuanghu Yuan, Jinming Yu

Pages: 2896-2905 Published online on: 10 September 2018

Prognostic value of monocarboxylate transporter 4 in patients with esophageal squamous cell carcinoma

Bo Cheng, Xuan Chen, Yankang Li, Xiaochen Huang, Jinming Yu

Pages: 2906-2915 Published online on: 13 September 2018

The interaction between miR‑148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer

Le Hong, Gen Sun, Long Peng, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao

Pages: 2916-2925 Published online on: 12 September 2018

Cryptotanshinone inhibits cellular proliferation of human lung cancer cells through downregulation ofIGF-1R/PI3K/Akt signaling pathway

Jingtao Zhang, Guilan Wen, Longhua Sun, Wenxin Yuan, Ran Wang, Qinghua Zeng, Guangyi Zhang, Bentong Yu

Pages: 2926-2934 Published online on: 10 August 2018

A novel peptide targets CD105 for tumour imaging in vivo

Xiaolong Li, Xiaofeng Huang, Jing Zhang, Hongxing Huang, Long Zhao, Mei Yu, Yan Zhang, Hua Wang

Pages: 2935-2943 Published online on: 14 August 2018

MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway

Bin Li, Cui‑Min Ding, Yan‑Xiao Li, Jing‑Cui Peng, Nan Geng, Wen‑Wen Qin

Pages: 2944-2954 Published online on: 23 August 2018

miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer

Zhuo Liu, Miao Yu, Bingyuan Fei, Xuedong Fang, Tonghui Ma, Dongxin Wang

Pages: 2955-2963 Published online on: 10 September 2018

Profile and validation of dysregulated long non‑coding RNAs and mRNAs in ovarian cancer

Yan‑Ming Lu, Yue Wang, Shi‑Qi Liu, Meng‑Ya Zhou, Ya‑Ru Guo

Pages: 2964-2976 Published online on: 17 August 2018

C16‑ceramide and sphingosine 1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation

Min Hee Kim, Joo‑Won Park, Eun‑Ji Lee, Shin Kim, Sun‑Hye Shin, Jung‑Hyuck Ahn, Yunjae Jung, Inkeun Park, Woo‑Jae Park

Pages: 2977-2987 Published online on: 07 September 2018

Downregulation of DLL4 predicts poor survival in non‑small cell lung cancer patients due to promotion of lymph node metastasis

Hongzhou Liu, Jie Peng, Meizhen Zhao, Pei Ma, Jun Zhong, Shuang Li, Zhongxin Lu

Pages: 2988-2996 Published online on: 31 August 2018

Increasing HER2 α2,6 sialylation facilitates gastric cancer progression and resistance via the Akt and ERK pathways

Naihua Liu, Menglu Zhu, Yingjie Linhai, Yuwei Song, Xiujuan Gui, Guoqiang Tan, Jinyuan Li, Yan Liu, Zhendong Deng, Xiaoting Chen, Jing Wang, Lili Jia, Xiuzhen He, Xiaoyu Wang, Shaoqiang Lin

Pages: 2997-3005 Published online on: 31 August 2018

Human umbilical vein endothelial cell vaccine suppresses the angiogenesis of esophageal squamous cell carcinoma in a humanized mouse model

Hangfan Liu, Jimin Zhao, Yi Yang, Guoguo Jin, Xiaoyan Zhang, Dongyu Wang, Chao Xie, Kangdong Liu, Xinhuan Chen, Xiang Li, Fang Tian, Ziming Dong, Jing Lu

Pages: 3006-3014 Published online on: 17 August 2018

Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner

Weikun Qian, Shifang Lv, Jie Li, Ke Chen, Zhengdong Jiang, Liang Cheng, Cancan Zhou, Bin Yan, Junyu Cao, Qingyong Ma, Wanxing Duan

Pages: 3015-3023 Published online on: 10 September 2018

Antitumor activity of the plant extract morin in tongue squamous cell carcinoma cells

Yawen Ji, Linglu Jia, Yunpeng Zhang, Yixiao Xing, Xuan Wu, Bin Zhao, Dondjiao Zhang, Xin Xu, Xu Qiao

Pages: 3024-3032 Published online on: 17 August 2018

Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2

Jian Wu, An‑Quan Shang, Chu Chen, Wei‑Wei Wang, Cun‑Quan Xiong, Nai‑Zhou Guo

Pages: 3033-3039 Published online on: 17 August 2018

Circadian clock gene Per2 downregulation in non‑small cell lung cancer is associated with tumour progression and metastasis

Run Xiang, Yue Cui, Yanping Wang, Tianpeng Xie, Xiaojun Yang, Zhu Wang, Juan Li, Qiang Li

Pages: 3040-3048 Published online on: 13 September 2018

Overexpression of Epsin 3 enhances migration and invasion of glioma cells by inducing epithelial‑mesenchymal transition

Yaru Wang, Wen Song, Pengcheng Kan, Chao Huang, Zhuolin Ma, Qiaoli Wu, Xiuhua Yao, Biao Zhang

Pages: 3049-3059 Published online on: 10 September 2018

Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration

Ruosi Yao, Yingli Wang, Danyang Han, Yuhui Ma, Musong Ma, Yaping Zhao, Jiang Tan, Jun Lu, Guiying Xu, Xiaoxue Li

Pages: 3069-3077 Published online on: 23 August 2018

Clinical relevance of the multidrug resistance‑associated protein 1 gene in non‑small cell lung cancer: A systematic review and meta‑analysis

Penghui Hu, Patrick Ting‑Yat Wong, Qinghua Zhou, Lianghe Sheng, Wenbo Niu, Size Chen, Meng Xu, Yiguang Lin

Pages: 3078-3091 Published online on: 17 August 2018

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

Xiang Pan, Zuwei Li, Liwen Zhao, Jing Quan, Liang Zhou, Jinling Xu, Weiji Xu, Xin Guan, Hang Li, Shangqi Yang, Yaoting Gui, Yongqing Lai

Pages: 3092-3101 Published online on: 17 August 2018
Open Access

[Retracted] Long non‑coding RNA MALAT1 interacts with miR‑124 and modulates tongue cancer growth by targeting JAG1

Tong‑Han Zhang, Li‑Zhong Liang, Xiao‑Ling Liu, Ji‑Nan Wu, Kui Su, Jue‑Yao Chen, Qiao‑Yi Zheng, Hong‑Zhang Huang, Gui‑Qing Liao

Pages: 3112-3112 Published online on: 06 September 2018
Open Access

[Corrigendum] Intratumoral injection of PKR shRNA expressing plasmid inhibits B16-F10 melanoma growth

Nayara Delgado André, Viviane Aline Oliveira Silva, Maria Angelica Ehara Watanabe, Fernando Luiz De Lucca

Pages: 3113-3113 Published online on: 14 August 2018
Journal Cover

November 2018
Volume 40 Issue 5

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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