Journal Articles

Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)

Mingzhe Li, Xin Bu, Bolei Cai, Ping Liang, Kai Li, Xuan Qu, Liangliang Shen

Pages: 727-741 Published online on: 23 November 2018
Open Access

NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells

Joana Marquez, Irina Kratchmarova, Vyacheslav Akimov, Fernando Unda, Gaskon Ibarretxe, Ariane Schaub Clerigué, Nerea Osinalde, Iker Badiola

Pages: 742-752 Published online on: 27 November 2018
Open Access

TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway

Jianbing Hou, Ailing Lv, Qing Deng, Guanghui Zhang, Xiaosong Hu, Hongjuan Cui

Pages: 753-764 Published online on: 09 November 2018
Open Access

Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells

Xin Chen, Liyan Song, Yuefang Hou, Fan Li

Pages: 765-778 Published online on: 12 November 2018
Open Access

CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A

Jun Lu, Jian‑Xian Lin, Peng‑Yang Zhang, Yu‑Qin Sun, Ping Li, Jian‑Wei Xie, Jia‑Bin Wang, Qi‑Yue Chen, Long‑Long Cao, Yao Lin, Chang‑Ming Huang, Chao‑Hui Zheng

Pages: 779-788 Published online on: 09 November 2018
Open Access

lincRNA‑p21 inhibits the progression of non‑small cell lung cancer via targeting miR‑17‑5p

Xiang Ao, Ming Jiang, Jie Zhou, Hongling Liang, Haoming Xia, Gang Chen

Pages: 789-800 Published online on: 30 November 2018
Open Access

Overexpression of MUC1 predicts poor prognosis in patients with breast cancer

Xuan Jing, Hongping Liang, Chonghua Hao, Xiaojuan Yang, Xiangrong Cui

Pages: 801-810 Published online on: 27 November 2018
Open Access

Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS‑mediated PI3K/AKT signaling pathway

Zhongbing Ma, Xingli Liu, Qiang Zhang, Zhigang Yu, Dezong Gao

Pages: 811-818 Published online on: 19 November 2018
Open Access

MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7

Junfeng Zhang, Shiyu Mao, Longsheng Wang, Wentao Zhang, Ziwei Zhang, Yadong Guo, Yuan Wu, Faxian Yi, Xudong Yao

Pages: 819-828 Published online on: 21 November 2018
Open Access

Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells

Xiao‑Tao Zhou, Ze‑Jin Pu, Li‑Xuan Liu, Guo‑Ping Li, Jia‑Lin Feng, Hua‑Chen Zhu, Ling‑Fei Wu

Pages: 829-838 Published online on: 30 November 2018
Open Access

Genetic, epigenetic and transcriptional comparison of esophagus tumor‑associated and adjacent normal myofibroblasts

Ildikó Huliák, László Bodai, Mátyás Czepán, Dávid Kovács, Anikó Szabó, László Tiszlavicz, György Lázár, Zoltán Rakonczay Jr, Péter Hegyi, Imre Miklós Boros, Mónika Kiricsi

Pages: 839-852 Published online on: 06 December 2018
Open Access

Hypoxia‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer

Yoko Kataoka, Yasuhiko Ohshio, Koji Teramoto, Tomoyuki Igarashi, Tohru Asai, Jun Hanaoka

Pages: 853-862 Published online on: 07 December 2018
Open Access

MicroRNA‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH

Qiwei Wang, Lijun Tan, Jiangtao Liu, Jiannan Zhao, Xiaojie Zhou, Tianjiao Yu

Pages: 863-874 Published online on: 06 December 2018
Open Access

Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer

Nanpeng Li, Daojiang Li, Yuheng Du, Chen Su, Chunxing Yang, Changwei Lin, Xiaorong Li, Gui Hu

Pages: 875-884 Published online on: 07 December 2018
Open Access

Pathway analysis of a genome‑wide association study on a long non‑coding RNA expression profile in oral squamous cell carcinoma

Yong‑Le Qiu, Yuan‑Hang Liu, Jian‑Dong Ban, Wen‑Jing Wang, Mei Han, Peng Kong, Bing‑Hui Li

Pages: 895-907 Published online on: 15 November 2018
Open Access

Ten genes associated with MGMT promoter methylation predict the prognosis of patients with glioma

Yang Zhang, Junwei Zhu

Pages: 908-916 Published online on: 04 December 2018
Open Access

Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition

Dan‑Hua Lu, Jiang Yang, Li‑Kun Gao, Jie Min, Jian‑Ming Tang, Ming Hu, Yang Li, Su‑Ting Li, Jing Chen, Li Hong

Pages: 917-927 Published online on: 27 November 2018
Open Access

Mechanical, nanomorphological and biological reconstruction of early‑stage apoptosis in HeLa cells induced by cytochalasin B

Xuelian Su, Ling Zhang, Hong Kang, Baoping Zhang, Guangjie Bao, Jizeng Wang

Pages: 928-938 Published online on: 07 December 2018
Open Access

Expression levels and co‑targets of miRNA‑126‑3p and miRNA‑126‑5p in lung adenocarcinoma tissues: Αn exploration with RT‑qPCR, microarray and bioinformatic analyses

Peng Chen, Yong‑Yao Gu, Fu‑Chao Ma, Rong‑Quan He, Zu‑Yun Li, Gao‑Qiang Zhai, Xia Lin, Xiao‑Hua Hu, Lin‑Jiang Pan, Gang Chen

Pages: 939-953 Published online on: 04 December 2018

Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells

Aya Yanagawa-Matsuda, Yohei Mikawa, Umma Habiba, Tetsuya Kitamura, Motoaki Yasuda, Mohammad Towfik-Alam, Yoshimasa Kitagawa, Kazuyuki Minowa, Masanobu Shindoh, Fumihiro Higashino

Pages: 954-960 Published online on: 12 November 2018

Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target

Tomohisa Horibe, Aya Torisawa, Yoshie Masuda, Koji Kawakami

Pages: 961-972 Published online on: 15 November 2018

Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1

Anaz Mohammed, Caixin Zhang, Shuwen Zhang , Qin Shen, Jieying Li, Zhiyuan Tang, Hua Liu

Pages: 973-980 Published online on: 09 November 2018

Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence

Zhun Zhang, Ning Song, Yanping Peng, Ziyan Fan, Mingyong Han, Min Zhao, Tianyi Dong, Shili Liu

Pages: 981-988 Published online on: 09 November 2018

Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer

Mingyue Zou, Xiaolei Hu, Bangtian Xu, Tingting Tong, Yixian Jing, Lei Xi, Wei Zhou, Jinpeng Lu, Xin Wang, Xiaolan Yang, Fei Liao

Pages: 989-998 Published online on: 09 November 2018

Mitochondrial‑DNA‑associated TLR9 signalling is a potential serological biomarker for non‑small cell lung cancer

Yu‑Heng Lai, Hao‑Yun Liu, Chun‑Yao Huang, Yat‑Pang Chau, Semon Wu

Pages: 999-1006 Published online on: 09 November 2018

Tumor suppressor PLZF regulated by lncRNA ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastric cancer cells

Jun‑Bin Wang, Yan Jin, Peng Wu, Yang Liu, Wen‑Jing Zhao, Jin‑Fei Chen, Wei De, Fen Yang

Pages: 1007-1018 Published online on: 12 November 2018

Comparative proteomic analysis identifies exosomal Eps8 protein as a potential metastatic biomarker for pancreatic cancer

Keiichi Ohshima, Keiichi Hatakeyama, Kaori Kanto, Tomomi Ide, Yuko Watanabe, Sachi Moromizato, Kanako Wakabayashi‑Nakao, Naoki Sakura, Ken Yamaguchi, Tohru Mochizuki

Pages: 1019-1034 Published online on: 15 November 2018

Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer

Yangyang Chen, Yifei Liu, Yanhong Zhou, Hongxia You

Pages: 1035-1044 Published online on: 21 November 2018

Association between interleukin‑33 and ovarian cancer

Xiaoqing Liu, Dwayne M. Hansen, Noah J. Timko, Ziwen Zhu, Andrew Ames, Chenglu Qin, Michael B. Nicholl, Qian Bai, Xuhui Chen, Mark R. Wakefield, Gage West, Yujiang Fang

Pages: 1045-1050 Published online on: 07 December 2018

Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis

Jiguang Ma, Mengwen Xue, Simei Zhang, Liang Cheng, Weikun Qian, Wanxing Duan, Xin Shen

Pages: 1051-1058 Published online on: 28 November 2018

Dual blockade of EGFR tyrosine kinase using osimertinib and afatinib eradicates EGFR‑mutant Ba/F3 cells

Kimio Yonesaka, Yoshihisa Kobayashi, Hidetoshi Hayashi, Yasutaka Chiba, Tetsuya Mitsudomi, Kazuhiko Nakagawa

Pages: 1059-1066 Published online on: 22 November 2018

Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway

Xuesong Zhang, Jianfeng Shao, Xinyan Li, Lihua Cui, Zhengbing Tan

Pages: 1067-1074 Published online on: 27 November 2018

TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells

Sangmin Kim, Daeun You, Yisun Jeong, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee

Pages: 1075-1082 Published online on: 06 December 2018

Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells

Ningning Zhang, Wei Jiang

Pages: 1083-1090 Published online on: 30 November 2018

Overexpression of ID1 promotes tumor progression in penile squamous cell carcinoma

Xiheng Hu, Mingfeng Chen, Yangle Li, Yin Wang, Sailan Wen, Fu Jun

Pages: 1091-1100 Published online on: 06 December 2018

YWHAZ promotes ovarian cancer metastasis by modulating glycolysis

Jie Shi, Jun Ye, He Fei, Shu‑Hen Jiang, Zhi‑Yong Wu, Ya‑Ping Chen, Li‑Wen Zhang, Xiao‑Mei Yang

Pages: 1101-1112 Published online on: 07 December 2018

HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27

Zefei Wang, Chunzhi Yu, Hong Wang

Pages: 1122-1130 Published online on: 20 November 2018

miR‑138‑5p modulates the expression of excision repair cross‑complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin

Jie Ning, Yang Jiao, Xiaoque Xie, Xuefei Deng, Yiyin Zhang, Yuexin Yang, Chenchen Zhao, Hua Wang, Kangsheng Gu

Pages: 1131-1139 Published online on: 06 December 2018
Open Access

Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer

Mohamed Ab. Kawan, Ioannis Kyrou, Manjunath Ramanjaneya, Kevin Williams, Jeyarooban Jeyaneethi, Harpal S. Randeva, Emmanouil Karteris

Pages: 1140-1150 Published online on: 27 November 2018

Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein‑induced hepatocarcinogenesis of L02/HBx cells

Yan Peng, Dejiang Zhou, Yusheng Ye, Chang Kai, Zhongyong Jiang, Ziyi Zhu, Xiaoling Wu, Jie Xiong

Pages: 1151-1159 Published online on: 15 November 2018

ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma

Ying Xiong, Hui Huang, Shaoping Chen, Haitao Dai, Luying Zhang

Pages: 1160-1168 Published online on: 05 November 2018

TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways

Jianqing Ye, Chuanmin Chu, Ming Chen, Zhan Shi, Sishun Gan, Fajun Qu, Xiuwu Pan, Qiwei Yang, Yijun Tian, Lei Wang, Wei Yang, Xingang Cui

Pages: 1169-1179 Published online on: 09 November 2018

Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway

Hui Xu, Xingai Jiao, Yilei Wu, Shuo Li, Lili Cao, Liang Dong

Pages: 1180-1188 Published online on: 09 November 2018

IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes

Bartlomiej E. Krazinski, Anna E. Kowalczyk, Agnieszka Sliwinska‑Jewsiewicka, Jedrzej Grzegrzolka, Janusz Godlewski, Przemyslaw Kwiatkowski, Piotr Dziegiel, Zbigniew Kmiec, Jolanta Kiewisz

Pages: 1189-1197 Published online on: 19 November 2018

Levistolide A synergistically enhances doxorubicin‑induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway

Yuanyuan Ding, Weibo Niu, Tao Zhang, Jue Wang, Jiao Cao, He Chen, Ruiqi Wang, Hongli An

Pages: 1198-1208 Published online on: 27 November 2018

Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers

Maria Ravo, Angela Cordella, Pasquale Saggese, Antonio Rinaldi, Maria Antonietta Castaldi, Giovanni Nassa, Giorgio Giurato, Fulvio Zullo, Alessandro Weisz, Roberta Tarallo, Francesca Rizzo, Maurizio Guida

Pages: 1209-1217 Published online on: 21 November 2018

miRNA‑885‑3p inhibits docetaxel chemoresistance in lung adenocarcinoma by downregulating Aurora A

Jiongrui Cao, Jian Geng, Xiaoyuan Chu, Rui Wang, Guichun Huang, Longbang Chen

Pages: 1218-1230 Published online on: 09 November 2018

MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7

Xiaofeng Tang, Weigang Yang, Zheyue Shu, Xiaodong Shen, Weichen Zhang, Chao Cen, Linping Cao, Min Zhang, Shusen Zheng, Jun Yu

Pages: 1231-1237 Published online on: 06 December 2018

Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration

Agata Mlynska, Greta Salciuniene, Karolina Zilionyte, Sima Garberyte, Marius Strioga, Birute Intaite, Ausrine Barakauskiene, Gianrocco Lazzari, Neringa Dobrovolskiene, Jan Aleksander Krasko, Vita Pasukoniene

Pages: 1238-1252 Published online on: 27 November 2018

Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma

Dingyuan Luo, Ying Liu, Shaojian Lin, Langping Tan, Zehu Du, Miaoyun Long, Yue Zhu, Xinzhi Peng, Weixing Zong, Gerardo G. Mackenzie, Honghao Li, Nengtai Ouyang

Pages: 1253-1263 Published online on: 28 November 2018

Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc‑1 cancer stem‑like cells

Guiqin Peng, Zongwei Tang, Yongjia Xiang, Wanyi Chen

Pages: 1264-1274 Published online on: 06 December 2018

Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells

D. Herrera, O. Orellana‑Serradell, P. Villar, M. J. Torres, R. Paciucci, E. A. Castellón, H. R. Contreras

Pages: 1275-1283 Published online on: 26 November 2018

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter

Wenlin Yang, Ying Su, Chenjian Hou, Linlin Chen, Danmei Zhou, Kehan Ren, Zhaoping Zhou, Renya Zhang, Xiuping Liu

Pages: 1284-1292 Published online on: 19 November 2018

Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC

Kentaro Jingushi, Motohide Uemura, Kosuke Nakano, Yujiro Hayashi, Cong Wang, Yu Ishizuya, Yoshiyuki Yamamoto, Takuji Hayashi, Toshiro Kinouchi, Kyosuke Matsuzaki, Taigo Kato, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Koji Ueda, Kazutake Tsujikawa, Norio Nonomura

Pages: 1293-1303 Published online on: 20 November 2018

BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer

Lei Xu, Hua Du, Qiang Zhang, Chao Wang, Li Yan, Guoying Tian, Xiuhua Fu

Pages: 1304-1312 Published online on: 26 November 2018

Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane

Agnieszka Żuryń, Adrian Krajewski, Anna Klimaszewska‑Wiśniewska, Alina Grzanka, Dariusz Grzanka

Pages: 1313-1323 Published online on: 07 December 2018

Caspase‑dependent apoptotic death by gadolinium chloride (GdCl3) via reactive oxygen species production and MAPK signaling in rat C6 glioma cells

Yuh‑Feng Tsai, Yuh‑Fung Chen, Chen‑Yu Hsiao, Ching‑Wen  Huang, Chi‑Cheng Lu, Shih‑Chang Tsai, Jai‑Sing Yang

Pages: 1324-1332 Published online on: 07 December 2018

Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells

María José Vázquez‑Mellado, Liliana Guadalupe Cortés‑Ballinas, Irma Carolina Blanco‑Flores, Cecilia Aguilar, Gerardo Vázquez‑Gómez, Leticia Rocha‑Zavaleta

Pages: 1333-1341 Published online on: 27 November 2018

miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis

Jia Liu, Jun Yuan, Tianxiang Feng, Yinjuan Zhao, Qian Sun, Jun Chen, Jingyu Chen, Meiling Jin, Bin Xue

Pages: 1342-1350 Published online on: 07 December 2018

Sodium cantharidinate suppresses human osteosarcoma MG‑63 cell proliferation and induces cell cycle arrest by inhibition of PI3K/AKT activation

Da‑Liang Kong, Yang Liu, Jing‑Ying Wang, Gong Liu, Ming‑Lei Zhang

Pages: 1351-1358 Published online on: 06 December 2018

MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma

Saif Zaman, Boris I. Chobrutskiy, Dhiraj Sikaria, George Blanck

Pages: 1359-1366 Published online on: 28 November 2018

Tumor p16INK4 gene expression and prognosis in colorectal cancer

Hirotaka Kitamura, Hirofumi Takemura, Toshinari Minamoto

Pages: 1367-1376 Published online on: 26 November 2018

Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines

Ahmad Fudhaili, Nal Ae Yoon, Seokmin Kang, Jinhyun Ryu, Joo Yeon Jeong, Dong Hoon Lee, Sang Soo Kang

Pages: 1377-1386 Published online on: 30 November 2018

Wnt/β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia

Jinqiu Fu, Libo Si, Yong Zhuang, Aijun Zhang, Nianzheng Sun, Dong Li, Bin Hao, Xiuli Ju

Pages: 1387-1394 Published online on: 04 December 2018

Downregulation of miR-95 in gastric cancer promotes EMT via regulation of Slug, thereby promoting migration and invasion

Wei Zhang, Jing Sun, Jinyan Chen, Caiyun Xu, Lixia Zhang

Pages: 1395-1403 Published online on: 06 December 2018

FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma

Wentao Xue, Linjie Ma, Zhiqian Wang, Weidong Zhang, Xiugong Zhang

Pages: 1404-1414 Published online on: 21 November 2018

AT‑101 induces G1/G0 phase arrest via the β‑catenin/cyclin D1 signaling pathway in human esophageal cancer cells

Fuchang Que, Lixia Dai, Dan Zhou, Qinghuan Lin, Xiaoyun Zeng, Le Yu, Yilei Li, Shuwen Liu

Pages: 1415-1423 Published online on: 20 November 2018
Open Access

[Corrigendum] Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation

Kai Yin, Mengyuan Shang, Shengchun Dang, Linjun Wang, Yiwen Xia, Lei Cui, Xin Fan, Jianguo Qu, Jixiang Chen, Zekuan Xu

Pages: 1424-1424 Published online on: 09 November 2018
Journal Cover

February 2019
Volume 41 Issue 2

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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