Journal Articles
Biological role of metabolic reprogramming of cancer cells during epithelial‑mesenchymal transition (Review)
Mingzhe Li, Xin Bu, Bolei Cai, Ping Liang, Kai Li, Xuan Qu, Liangliang Shen
Pages: 727-741 Published online on: 23 November 2018
NADH dehydrogenase complex I is overexpressed in incipient metastatic murine colon cancer cells
Joana Marquez, Irina Kratchmarova, Vyacheslav Akimov, Fernando Unda, Gaskon Ibarretxe, Ariane Schaub Clerigué, Nerea Osinalde, Iker Badiola
Pages: 742-752 Published online on: 27 November 2018
TROP2 promotes the proliferation and metastasis of glioblastoma cells by activating the JAK2/STAT3 signaling pathway
Jianbing Hou, Ailing Lv, Qing Deng, Guanghui Zhang, Xiaosong Hu, Hongjuan Cui
Pages: 753-764 Published online on: 09 November 2018
Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells
Xin Chen, Liyan Song, Yuefang Hou, Fan Li
Pages: 765-778 Published online on: 12 November 2018
CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A
Jun Lu, Jian‑Xian Lin, Peng‑Yang Zhang, Yu‑Qin Sun, Ping Li, Jian‑Wei Xie, Jia‑Bin Wang, Qi‑Yue Chen, Long‑Long Cao, Yao Lin, Chang‑Ming Huang, Chao‑Hui Zheng
Pages: 779-788 Published online on: 09 November 2018
lincRNA‑p21 inhibits the progression of non‑small cell lung cancer via targeting miR‑17‑5p
Xiang Ao, Ming Jiang, Jie Zhou, Hongling Liang, Haoming Xia, Gang Chen
Pages: 789-800 Published online on: 30 November 2018
Overexpression of MUC1 predicts poor prognosis in patients with breast cancer
Xuan Jing, Hongping Liang, Chonghua Hao, Xiaojuan Yang, Xiangrong Cui
Pages: 801-810 Published online on: 27 November 2018
Carvedilol suppresses malignant proliferation of mammary epithelial cells through inhibition of the ROS‑mediated PI3K/AKT signaling pathway
Zhongbing Ma, Xingli Liu, Qiang Zhang, Zhigang Yu, Dezong Gao
Pages: 811-818 Published online on: 19 November 2018
MicroRNA‑154 functions as a tumor suppressor in bladder cancer by directly targeting ATG7
Junfeng Zhang, Shiyu Mao, Longsheng Wang, Wentao Zhang, Ziwei Zhang, Yadong Guo, Yuan Wu, Faxian Yi, Xudong Yao
Pages: 819-828 Published online on: 21 November 2018
Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells
Xiao‑Tao Zhou, Ze‑Jin Pu, Li‑Xuan Liu, Guo‑Ping Li, Jia‑Lin Feng, Hua‑Chen Zhu, Ling‑Fei Wu
Pages: 829-838 Published online on: 30 November 2018
Genetic, epigenetic and transcriptional comparison of esophagus tumor‑associated and adjacent normal myofibroblasts
Ildikó Huliák, László Bodai, Mátyás Czepán, Dávid Kovács, Anikó Szabó, László Tiszlavicz, György Lázár, Zoltán Rakonczay Jr, Péter Hegyi, Imre Miklós Boros, Mónika Kiricsi
Pages: 839-852 Published online on: 06 December 2018
Hypoxia‑induced galectin‑3 enhances RhoA function to activate the motility of tumor cells in non‑small cell lung cancer
Yoko Kataoka, Yasuhiko Ohshio, Koji Teramoto, Tomoyuki Igarashi, Tohru Asai, Jun Hanaoka
Pages: 853-862 Published online on: 07 December 2018
MicroRNA‑98/PTEN/AKT pathway inhibits cell proliferation and malignant progression of hypopharyngeal carcinoma by MTDH
Qiwei Wang, Lijun Tan, Jiangtao Liu, Jiannan Zhao, Xiaojie Zhou, Tianjiao Yu
Pages: 863-874 Published online on: 06 December 2018
Overexpressed PLAGL2 transcriptionally activates Wnt6 and promotes cancer development in colorectal cancer
Nanpeng Li, Daojiang Li, Yuheng Du, Chen Su, Chunxing Yang, Changwei Lin, Xiaorong Li, Gui Hu
Pages: 875-884 Published online on: 07 December 2018
Potential efficacy and prognosis of silencing the CRLF2‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia
Min Jiang, Xueqin Zou, Lingyun Lu
Pages: 885-894 Published online on: 07 December 2018
Pathway analysis of a genome‑wide association study on a long non‑coding RNA expression profile in oral squamous cell carcinoma
Yong‑Le Qiu, Yuan‑Hang Liu, Jian‑Dong Ban, Wen‑Jing Wang, Mei Han, Peng Kong, Bing‑Hui Li
Pages: 895-907 Published online on: 15 November 2018
Ten genes associated with MGMT promoter methylation predict the prognosis of patients with glioma
Yang Zhang, Junwei Zhu
Pages: 908-916 Published online on: 04 December 2018
Lysine demethylase 2A promotes the progression of ovarian cancer by regulating the PI3K pathway and reversing epithelial‑mesenchymal transition
Dan‑Hua Lu, Jiang Yang, Li‑Kun Gao, Jie Min, Jian‑Ming Tang, Ming Hu, Yang Li, Su‑Ting Li, Jing Chen, Li Hong
Pages: 917-927 Published online on: 27 November 2018
Mechanical, nanomorphological and biological reconstruction of early‑stage apoptosis in HeLa cells induced by cytochalasin B
Xuelian Su, Ling Zhang, Hong Kang, Baoping Zhang, Guangjie Bao, Jizeng Wang
Pages: 928-938 Published online on: 07 December 2018
Expression levels and co‑targets of miRNA‑126‑3p and miRNA‑126‑5p in lung adenocarcinoma tissues: Αn exploration with RT‑qPCR, microarray and bioinformatic analyses
Peng Chen, Yong‑Yao Gu, Fu‑Chao Ma, Rong‑Quan He, Zu‑Yun Li, Gao‑Qiang Zhai, Xia Lin, Xiao‑Hua Hu, Lin‑Jiang Pan, Gang Chen
Pages: 939-953 Published online on: 04 December 2018
Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells
Aya Yanagawa-Matsuda, Yohei Mikawa, Umma Habiba, Tetsuya Kitamura, Motoaki Yasuda, Mohammad Towfik-Alam, Yoshimasa Kitagawa, Kazuyuki Minowa, Masanobu Shindoh, Fumihiro Higashino
Pages: 954-960 Published online on: 12 November 2018
Functional analysis of protein disulfide isomerase P5 in glioblastoma cells as a novel anticancer target
Tomohisa Horibe, Aya Torisawa, Yoshie Masuda, Koji Kawakami
Pages: 961-972 Published online on: 15 November 2018
Inhibition of cell proliferation and migration in non‑small cell lung cancer cells through the suppression of LYPLA1
Anaz Mohammed, Caixin Zhang, Shuwen Zhang , Qin Shen, Jieying Li, Zhiyuan Tang, Hua Liu
Pages: 973-980 Published online on: 09 November 2018
Evironmental pollutant perfluorodecanoic acid upregulates cIAP2 to suppress gastric cell senescence
Zhun Zhang, Ning Song, Yanping Peng, Ziyan Fan, Mingyong Han, Min Zhao, Tianyi Dong, Shili Liu
Pages: 981-988 Published online on: 09 November 2018
Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer
Mingyue Zou, Xiaolei Hu, Bangtian Xu, Tingting Tong, Yixian Jing, Lei Xi, Wei Zhou, Jinpeng Lu, Xin Wang, Xiaolan Yang, Fei Liao
Pages: 989-998 Published online on: 09 November 2018
Mitochondrial‑DNA‑associated TLR9 signalling is a potential serological biomarker for non‑small cell lung cancer
Yu‑Heng Lai, Hao‑Yun Liu, Chun‑Yao Huang, Yat‑Pang Chau, Semon Wu
Pages: 999-1006 Published online on: 09 November 2018
Tumor suppressor PLZF regulated by lncRNA ANRIL suppresses proliferation and epithelial mesenchymal transformation of gastric cancer cells
Jun‑Bin Wang, Yan Jin, Peng Wu, Yang Liu, Wen‑Jing Zhao, Jin‑Fei Chen, Wei De, Fen Yang
Pages: 1007-1018 Published online on: 12 November 2018
Comparative proteomic analysis identifies exosomal Eps8 protein as a potential metastatic biomarker for pancreatic cancer
Keiichi Ohshima, Keiichi Hatakeyama, Kaori Kanto, Tomomi Ide, Yuko Watanabe, Sachi Moromizato, Kanako Wakabayashi‑Nakao, Naoki Sakura, Ken Yamaguchi, Tohru Mochizuki
Pages: 1019-1034 Published online on: 15 November 2018
Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer
Yangyang Chen, Yifei Liu, Yanhong Zhou, Hongxia You
Pages: 1035-1044 Published online on: 21 November 2018
Association between interleukin‑33 and ovarian cancer
Xiaoqing Liu, Dwayne M. Hansen, Noah J. Timko, Ziwen Zhu, Andrew Ames, Chenglu Qin, Michael B. Nicholl, Qian Bai, Xuhui Chen, Mark R. Wakefield, Gage West, Yujiang Fang
Pages: 1045-1050 Published online on: 07 December 2018
Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis
Jiguang Ma, Mengwen Xue, Simei Zhang, Liang Cheng, Weikun Qian, Wanxing Duan, Xin Shen
Pages: 1051-1058 Published online on: 28 November 2018
Dual blockade of EGFR tyrosine kinase using osimertinib and afatinib eradicates EGFR‑mutant Ba/F3 cells
Kimio Yonesaka, Yoshihisa Kobayashi, Hidetoshi Hayashi, Yasutaka Chiba, Tetsuya Mitsudomi, Kazuhiko Nakagawa
Pages: 1059-1066 Published online on: 22 November 2018
Docetaxel promotes cell apoptosis and decreases SOX2 expression in CD133‑expressing hepatocellular carcinoma stem cells by suppressing the PI3K/AKT signaling pathway
Xuesong Zhang, Jianfeng Shao, Xinyan Li, Lihua Cui, Zhengbing Tan
Pages: 1067-1074 Published online on: 27 November 2018
TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells
Sangmin Kim, Daeun You, Yisun Jeong, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
Pages: 1075-1082 Published online on: 06 December 2018
Long non‑coding RNA DANCR promotes HMGA2‑mediated invasion in lung adenocarcinoma cells
Ningning Zhang, Wei Jiang
Pages: 1083-1090 Published online on: 30 November 2018
Overexpression of ID1 promotes tumor progression in penile squamous cell carcinoma
Xiheng Hu, Mingfeng Chen, Yangle Li, Yin Wang, Sailan Wen, Fu Jun
Pages: 1091-1100 Published online on: 06 December 2018
YWHAZ promotes ovarian cancer metastasis by modulating glycolysis
Jie Shi, Jun Ye, He Fei, Shu‑Hen Jiang, Zhi‑Yong Wu, Ya‑Ping Chen, Li‑Wen Zhang, Xiao‑Mei Yang
Pages: 1101-1112 Published online on: 07 December 2018
Long non‑coding RNA MALAT1 correlates with cell viability and mobility by targeting miR‑22‑3p in renal cell carcinoma via the PI3K/Akt pathway
Zhong Li, Zhiqiang Ma, Xiangdong Xu
Pages: 1113-1121 Published online on: 06 November 2018
HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27
Zefei Wang, Chunzhi Yu, Hong Wang
Pages: 1122-1130 Published online on: 20 November 2018
miR‑138‑5p modulates the expression of excision repair cross‑complementing proteins ERCC1 and ERCC4, and regulates the sensitivity of gastric cancer cells to cisplatin
Jie Ning, Yang Jiao, Xiaoque Xie, Xuefei Deng, Yiyin Zhang, Yuexin Yang, Chenchen Zhao, Hua Wang, Kangsheng Gu
Pages: 1131-1139 Published online on: 06 December 2018
Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer
Mohamed Ab. Kawan, Ioannis Kyrou, Manjunath Ramanjaneya, Kevin Williams, Jeyarooban Jeyaneethi, Harpal S. Randeva, Emmanouil Karteris
Pages: 1140-1150 Published online on: 27 November 2018
Epigenetic knockdown of Notch1 inhibits hepatitis B virus X protein‑induced hepatocarcinogenesis of L02/HBx cells
Yan Peng, Dejiang Zhou, Yusheng Ye, Chang Kai, Zhongyong Jiang, Ziyi Zhu, Xiaoling Wu, Jie Xiong
Pages: 1151-1159 Published online on: 15 November 2018
ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma
Ying Xiong, Hui Huang, Shaoping Chen, Haitao Dai, Luying Zhang
Pages: 1160-1168 Published online on: 05 November 2018
TROAP regulates prostate cancer progression via the WNT3/survivin signalling pathways
Jianqing Ye, Chuanmin Chu, Ming Chen, Zhan Shi, Sishun Gan, Fajun Qu, Xiuwu Pan, Qiwei Yang, Yijun Tian, Lei Wang, Wei Yang, Xingang Cui
Pages: 1169-1179 Published online on: 09 November 2018
Exosomes derived from PM2.5‑treated lung cancer cells promote the growth of lung cancer via the Wnt3a/β‑catenin pathway
Hui Xu, Xingai Jiao, Yilei Wu, Shuo Li, Lili Cao, Liang Dong
Pages: 1180-1188 Published online on: 09 November 2018
IKBKB expression in clear cell renal cell carcinoma is associated with tumor grade and patient outcomes
Bartlomiej E. Krazinski, Anna E. Kowalczyk, Agnieszka Sliwinska‑Jewsiewicka, Jedrzej Grzegrzolka, Janusz Godlewski, Przemyslaw Kwiatkowski, Piotr Dziegiel, Zbigniew Kmiec, Jolanta Kiewisz
Pages: 1189-1197 Published online on: 19 November 2018
Levistolide A synergistically enhances doxorubicin‑induced apoptosis of k562/dox cells by decreasing MDR1 expression through the ubiquitin pathway
Yuanyuan Ding, Weibo Niu, Tao Zhang, Jue Wang, Jiao Cao, He Chen, Ruiqi Wang, Hongli An
Pages: 1198-1208 Published online on: 27 November 2018
Identification of long non‑coding RNA expression patterns useful for molecular‑based classification of type I endometrial cancers
Maria Ravo, Angela Cordella, Pasquale Saggese, Antonio Rinaldi, Maria Antonietta Castaldi, Giovanni Nassa, Giorgio Giurato, Fulvio Zullo, Alessandro Weisz, Roberta Tarallo, Francesca Rizzo, Maurizio Guida
Pages: 1209-1217 Published online on: 21 November 2018
miRNA‑885‑3p inhibits docetaxel chemoresistance in lung adenocarcinoma by downregulating Aurora A
Jiongrui Cao, Jian Geng, Xiaoyuan Chu, Rui Wang, Guichun Huang, Longbang Chen
Pages: 1218-1230 Published online on: 09 November 2018
MicroRNA‑223 promotes hepatocellular carcinoma cell resistance to sorafenib by targeting FBW7
Xiaofeng Tang, Weigang Yang, Zheyue Shu, Xiaodong Shen, Weichen Zhang, Chao Cen, Linping Cao, Min Zhang, Shusen Zheng, Jun Yu
Pages: 1231-1237 Published online on: 06 December 2018
Chemokine profiling in serum from patients with ovarian cancer reveals candidate biomarkers for recurrence and immune infiltration
Agata Mlynska, Greta Salciuniene, Karolina Zilionyte, Sima Garberyte, Marius Strioga, Birute Intaite, Ausrine Barakauskiene, Gianrocco Lazzari, Neringa Dobrovolskiene, Jan Aleksander Krasko, Vita Pasukoniene
Pages: 1238-1252 Published online on: 27 November 2018
Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma
Dingyuan Luo, Ying Liu, Shaojian Lin, Langping Tan, Zehu Du, Miaoyun Long, Yue Zhu, Xinzhi Peng, Weixing Zong, Gerardo G. Mackenzie, Honghao Li, Nengtai Ouyang
Pages: 1253-1263 Published online on: 28 November 2018
Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc‑1 cancer stem‑like cells
Guiqin Peng, Zongwei Tang, Yongjia Xiang, Wanyi Chen
Pages: 1264-1274 Published online on: 06 December 2018
Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells
D. Herrera, O. Orellana‑Serradell, P. Villar, M. J. Torres, R. Paciucci, E. A. Castellón, H. R. Contreras
Pages: 1275-1283 Published online on: 26 November 2018
SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter
Wenlin Yang, Ying Su, Chenjian Hou, Linlin Chen, Danmei Zhou, Kehan Ren, Zhaoping Zhou, Renya Zhang, Xiuping Liu
Pages: 1284-1292 Published online on: 19 November 2018
Leukocyte‑associated immunoglobulin‑like receptor 1 promotes tumorigenesis in RCC
Kentaro Jingushi, Motohide Uemura, Kosuke Nakano, Yujiro Hayashi, Cong Wang, Yu Ishizuya, Yoshiyuki Yamamoto, Takuji Hayashi, Toshiro Kinouchi, Kyosuke Matsuzaki, Taigo Kato, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Kazutoshi Fujita, Koji Ueda, Kazutake Tsujikawa, Norio Nonomura
Pages: 1293-1303 Published online on: 20 November 2018
BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer
Lei Xu, Hua Du, Qiang Zhang, Chao Wang, Li Yan, Guoying Tian, Xiuhua Fu
Pages: 1304-1312 Published online on: 26 November 2018
Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane
Agnieszka Żuryń, Adrian Krajewski, Anna Klimaszewska‑Wiśniewska, Alina Grzanka, Dariusz Grzanka
Pages: 1313-1323 Published online on: 07 December 2018
Caspase‑dependent apoptotic death by gadolinium chloride (GdCl3) via reactive oxygen species production and MAPK signaling in rat C6 glioma cells
Yuh‑Feng Tsai, Yuh‑Fung Chen, Chen‑Yu Hsiao, Ching‑Wen Huang, Chi‑Cheng Lu, Shih‑Chang Tsai, Jai‑Sing Yang
Pages: 1324-1332 Published online on: 07 December 2018
Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells
María José Vázquez‑Mellado, Liliana Guadalupe Cortés‑Ballinas, Irma Carolina Blanco‑Flores, Cecilia Aguilar, Gerardo Vázquez‑Gómez, Leticia Rocha‑Zavaleta
Pages: 1333-1341 Published online on: 27 November 2018
miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis
Jia Liu, Jun Yuan, Tianxiang Feng, Yinjuan Zhao, Qian Sun, Jun Chen, Jingyu Chen, Meiling Jin, Bin Xue
Pages: 1342-1350 Published online on: 07 December 2018
Sodium cantharidinate suppresses human osteosarcoma MG‑63 cell proliferation and induces cell cycle arrest by inhibition of PI3K/AKT activation
Da‑Liang Kong, Yang Liu, Jing‑Ying Wang, Gong Liu, Ming‑Lei Zhang
Pages: 1351-1358 Published online on: 06 December 2018
MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma
Saif Zaman, Boris I. Chobrutskiy, Dhiraj Sikaria, George Blanck
Pages: 1359-1366 Published online on: 28 November 2018
Tumor p16INK4 gene expression and prognosis in colorectal cancer
Hirotaka Kitamura, Hirofumi Takemura, Toshinari Minamoto
Pages: 1367-1376 Published online on: 26 November 2018
Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines
Ahmad Fudhaili, Nal Ae Yoon, Seokmin Kang, Jinhyun Ryu, Joo Yeon Jeong, Dong Hoon Lee, Sang Soo Kang
Pages: 1377-1386 Published online on: 30 November 2018
Wnt/β‑catenin inhibition reverses multidrug resistance in pediatric acute lymphoblastic leukemia
Jinqiu Fu, Libo Si, Yong Zhuang, Aijun Zhang, Nianzheng Sun, Dong Li, Bin Hao, Xiuli Ju
Pages: 1387-1394 Published online on: 04 December 2018
Downregulation of miR-95 in gastric cancer promotes EMT via regulation of Slug, thereby promoting migration and invasion
Wei Zhang, Jing Sun, Jinyan Chen, Caiyun Xu, Lixia Zhang
Pages: 1395-1403 Published online on: 06 December 2018
FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma
Wentao Xue, Linjie Ma, Zhiqian Wang, Weidong Zhang, Xiugong Zhang
Pages: 1404-1414 Published online on: 21 November 2018
AT‑101 induces G1/G0 phase arrest via the β‑catenin/cyclin D1 signaling pathway in human esophageal cancer cells
Fuchang Que, Lixia Dai, Dan Zhou, Qinghuan Lin, Xiaoyun Zeng, Le Yu, Yilei Li, Shuwen Liu
Pages: 1415-1423 Published online on: 20 November 2018
