Journal Articles

Open Access

Roles of the inflammasome in the gut‑liver axis (Review)

Junfeng Wang, Rui Dong, Shan Zheng

Pages: 3-14 Published online on: 20 November 2018
Open Access

Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)

Martha Cristina Diaz‑Franco, Raul Franco‑Diaz de Leon, Jose Rafael Villafan‑Bernal

Pages: 15-22 Published online on: 05 November 2018

Molecular targets of curcumin in breast cancer (Review)

Xinqiang Song, Mu Zhang, Erqin Dai, Yuan Luo

Pages: 23-29 Published online on: 19 November 2018
Open Access

Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis

Rongqiang Zhang, Xiaoli Yang, Jing Wang, Lixin Han, Aimin Yang, Jie Zhang, Dandan Zhang, Baorong Li, Zhaofang Li, Yongmin Xiong

Pages: 30-40 Published online on: 20 November 2018
Open Access

Long‑term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL/6J mice inner hair cell ribbon synapse

Wanming Cui, Haolin Wang, Yu Cheng, Xiaorui Ma, Yu Lei, Xingxing Ruan, Lin Shi, Mei Lv

Pages: 51-58 Published online on: 05 November 2018
Open Access

PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression

Xia Wang, Xu Liu, Yuan Ren, Ying Liu, Shuangyu Han, Jingkang Zhao, Xingchun Gou, Yuan He

Pages: 59-74 Published online on: 12 November 2018
Open Access

PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis

Jie Wu, Sheng Xiao, Miaomiao Yuan, Qianyuan Li, Guangfen Xiao, Wei Wu, Yuexian Ouyang, Lihua Huang, Chenjiao Yao

Pages: 75-84 Published online on: 06 November 2018
Open Access

Downregulation of NLRP2 inhibits HUVEC viability by inhibiting the MAPK signaling pathway

Xiaolu Zhang, Xinlei Lu, Limei Yu, Yufeng Gu, Fuzheng Qu

Pages: 85-92 Published online on: 05 November 2018
Open Access

Microarray analysis of the molecular mechanisms associated with age and body mass index in human meniscal injury

Peiyan Huang, Jun Gu, Junguo Wu, Lei Geng, Yang Hong, Siqun Wang , Minghai Wang

Pages: 93-102 Published online on: 21 November 2018
Open Access

Potential functions of long non‑coding RNAs in the osteogenic differentiation of human bone marrow mesenchymal stem cells

Xiang Sun, Bo Jia, Xiao‑Ling Qiu, Hong‑Xing Chu, Zhao‑Qiang Zhang, Zhi‑Ping Wang, Jian‑Jiang Zhao

Pages: 103-114 Published online on: 20 November 2018
Open Access

Integration of high‑throughput data of microRNA and mRNA expression profiles reveals novel insights into the mechanism of liver fibrosis

Yitong Zhang, Jing Liu, Yanyun Ma, Jingjie Wang, Jie Zhu, Jie Liu, Jun Zhang

Pages: 115-124 Published online on: 09 November 2018
Open Access

Platelet‑derived growth factor D promotes the angiogenic capacity of endothelial progenitor cells

Jianbo Zhang, Haolong Zhang, Yikuan Chen, Jian Fu, Yu Lei, Jianming Sun, Bo Tang

Pages: 125-132 Published online on: 26 November 2018
Open Access

Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo

Guixiang Tian, Xiue Sun, Jingkun Bai, Jinhua Dong, Bo Zhang, Zhiqin Gao, Jingliang Wu

Pages: 133-142 Published online on: 22 November 2018
Open Access

Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis

Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui, Wenxia Meng, Wei Guo, Baoshan Wang

Pages: 143-154 Published online on: 09 November 2018
Open Access

Differential expression profiles of long non‑coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity

Meiying Feng, Nannan Dang, Yinshan Bai, Hengxi Wei, Li Meng, Kai Wang, Zhihong Zhao, Yun Chen, Fenglei Gao, Zhilin Chen, Li Li, Shouquan Zhang

Pages: 155-164 Published online on: 20 November 2018
Open Access

Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells

Yun‑Qian Guan, Chun‑Song Zhao, Hai‑Qiang Zou, Xiao‑Ming Yan, Lu‑Lu Luo, Jia‑Lin Wu, Xiaobo Li, Yu Alex Zhang

Pages: 165-176 Published online on: 19 November 2018
Open Access

Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways

Simeng Wu, Yajun Wang, Zhe Yuan, Siliang Wang, Hongmei Du, Xue Liu, Qiushi Wang, Xike Zhu

Pages: 177-186 Published online on: 19 November 2018
Open Access

Isolation and multipotential differentiation of mesenchymal stromal cell‑like progenitor cells from human bladder

Jun Lu, Ling‑Feng Zhu, Yuan‑Ming Cai, Hui‑Yue Dong, Ling Zhu, Jian‑Ming Tan

Pages: 187-194 Published online on: 12 November 2018
Open Access

Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone

Lang Gan, Shuguang Pan, Jinchi Cui, Jie Bai, Peng Jiang, Yu He

Pages: 195-204 Published online on: 15 November 2018
Open Access

Puerarin promotes DUSP1 expression by regulating miR‑133a‑3p in breast cancer

Zhifeng Li, Weiwei Xu, Xiaoyan Ren, Jinhua Xu, Jianxin Chen

Pages: 205-212 Published online on: 21 November 2018
Open Access

MG132 selectively upregulates MICB through the DNA damage response pathway in A549 cells

Dan Luo, Xi‑Wen Dong, Bing Yan, Mei Liu, Tian‑Hui Xue, Hui Liu, Jun‑Hao You, Fang Li, Zi‑Ling Wang, Zhi‑Nan Chen

Pages: 213-220 Published online on: 20 November 2018
Open Access

Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome‑mediated inflammation

Jingxiao Lu, Yang Su, Xianguo Chen, Yuan Chen, Pengcheng Luo, Fangyou Lin, Jie Zhang

Pages: 221-230 Published online on: 21 November 2018
Open Access

P4HB knockdown induces human HT29 colon cancer cell apoptosis through the generation of reactive oxygen species and inactivation of STAT3 signaling

Ying Zhou, Jing Yang, Qilin Zhang, Qihua Xu, Lihua Lu, Jiening Wang, Wei Xia

Pages: 231-237 Published online on: 15 November 2018
Open Access

Establishment of microRNA, transcript and protein regulatory networks in Alport syndrome induced pluripotent stem cells

Wenbiao Chen, Donge Tang, Yong Dai, Hongyan Diao

Pages: 238-250 Published online on: 20 November 2018
Open Access

FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling

Qinchen Cao, Xinxin Wang, Yonggang Shi, Mingzhi Zhang, Jing Yang, Meilian Dong, Yin Mi, Zhigang Zhang, Ke Liu, Li Jiang, Na Wang, Ping Wang

Pages: 251-261 Published online on: 13 November 2018
Open Access

Hepatitis B virus core protein dimer‑dimer interface is critical for viral replication

Chang‑Long Zheng, Yong‑Mei Fu, Zhan‑Xue Xu, Yong Zou, Kai Deng

Pages: 262-270 Published online on: 02 November 2018
Open Access

Hypoxia‑induced miR‑210 contributes to apoptosis of mouse spermatocyte GC‑2 cells by targeting Kruppel‑like factor 7

Jin‑Xing Lv, Jian Zhou, Rui‑Qing Tong, Bin Wang, Xue‑Lei Chen, Yan‑Yan Zhuang, Fei Xia, Xue‑Dong Wei

Pages: 271-279 Published online on: 12 November 2018
Open Access

UPLC/Q‑TOF‑MS based plasma metabolomics and clinical characteristics of polycystic ovarian syndrome

Xuemei Fan, Jianfa Jiang, Zhiqiang Huang, Jumei Gong, Yiming Wang, Wei Xue, Yan Deng, Yanfang Wang, Tingping Zheng, Aijun Sun, Guoan Luo

Pages: 280-292 Published online on: 12 November 2018
Open Access

The role of E2F8 in the human placenta

Masako Mizuno, Rika Miki, Yoshinori Moriyama, Takafumi Ushida, Kenji Imai, Kaoru Niimi, Tomoko Nakano, Hiroyuki Tsuda, Seiji Sumigama, Eiko Yamamoto, Takeshi Senga, Akira Iwase, Fumitaka Kikkawa, Tomomi Kotani

Pages: 293-301 Published online on: 01 November 2018
Open Access

Expression profile of long non‑coding RNAs in cardiomyocytes exposed to acute ischemic hypoxia

Hua Li, Zijie Cheng, Yuanyuan Tang, Mengwen Feng, Anwen Yin, Hao Zhang, Jia Xu, Qijun Zhang, Jinsong Zhang, Lingmei Qian

Pages: 302-308 Published online on: 13 November 2018
Open Access

CagA increases DNA methylation and decreases PTEN expression in human gastric cancer

Baogui Zhang, Xiaobei Zhang, Meng Jin, Lei Hu, Mingde Zang, Weilong Qiu, Shouqi Wang, Bingya Liu, Shiqi Liu, Dongli Guo

Pages: 309-319 Published online on: 13 November 2018
Open Access

Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis

Bingqian Wang, Wenna Li, Hezhi Fang, Huaibin Zhou

Pages: 320-326 Published online on: 02 November 2018
Open Access

c‑Jun N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats

Geng‑Qiang Ling, Xian‑Feng Li, Xu‑Hui Lei, Zhen‑Yu Wang, Dong‑Ying Ma, Yue‑Na Wang, Wei Ye

Pages: 327-337 Published online on: 09 November 2018
Open Access

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat Schwann cells in vitro

Qing Li, Yang Jiao, Yang Yu, Guolin Wang, Yonghao Yu

Pages: 338-344 Published online on: 08 November 2018
Open Access

Identification of key candidate genes and miRNA‑mRNA target pairs in chronic lymphocytic leukemia by integrated bioinformatics analysis

Chundi Gao, Chao Zhou, Jing Zhuang, Lijuan Liu, Junyu Wei, Cun Liu, Huayao Li, Changgang Sun

Pages: 362-374 Published online on: 09 November 2018
Open Access

Enhanced adhesion and proliferation of bone marrow mesenchymal stem cells on β‑tricalcium phosphate modified by an affinity peptide

Guozong Wang, Zhentao Man, Hua Xin, Yi Li, Changshun Wu, Shui Sun

Pages: 375-381 Published online on: 13 November 2018
Open Access

Progranulin protects the mouse retina under hypoxic conditions via inhibition of the Toll‑like receptor‑4‑NADPH oxidase 4 signaling pathway

Zhi‑Peng You, Meng‑Jia Yu, Yu‑Lan Zhang, Ke Shi

Pages: 382-390 Published online on: 08 November 2018
Open Access

Genome‑wide DNA methylation analysis of uterosacral ligaments in women with pelvic organ prolapse

Lifang Zhang, Ping Zheng, Aihong Duan, Yan Hao, Chang Lu, Dan Lu

Pages: 391-399 Published online on: 13 November 2018
Open Access

Visfatin is regulated by interleukin‑6 and affected by the PPAR‑γ pathway in BeWo cells

Yanhong Zhang, Yan Huo, Wenhui He, Suxin Liu, Hongyan Li, Li Li

Pages: 400-406 Published online on: 20 November 2018
Open Access

Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

Guozong Wang, Zhentao Man, Nianping Zhang, Hua Xin, Yi Li, Tiantong Sun, Shui Sun

Pages: 407-413 Published online on: 05 November 2018
Open Access

Streptolysin O derived from Streptococcus pyogenes inhibits RANKL‑induced osteoclastogenesis through the NF‑κB signaling pathway

Jin Yi, Ruohui Tang, Jing Yang, Yueqi Chen, Jun Fei

Pages: 414-422 Published online on: 15 November 2018
Open Access

Genistein attenuates renal fibrosis in streptozotocin‑induced diabetic rats

Qiang Jia, Rui Yang, Xiao‑Fen Liu, Shan‑Feng Ma, Lei Wang

Pages: 423-431 Published online on: 09 November 2018
Open Access

Rosuvastatin protects against oxidized low‑density lipoprotein‑induced endothelial cell injury of atherosclerosis in vitro

Jianan Geng, Huali Xu, Xiaofeng Yu, Guoliang Xu, Hongyan Cao, Guangzhu Lin, Dayun Sui

Pages: 432-440 Published online on: 19 November 2018
Open Access

Potential four‑miRNA signature associated with T stage and prognosis of patients with pancreatic ductal adenocarcinoma identified by co‑expression analysis

Lukuan You, Jinliang Wang, Fan Zhang, Jing Zhang, Haitao Tao, Xuan Zheng, Yi Hu

Pages: 441-451 Published online on: 19 November 2018
Open Access

Therapeutic effects of a liquid bandage prepared with cellulose powders from Styela clava tunics and Broussonetia kazinoki bark: Healing of surgical wounds on the skin of Sprague Dawley rats

Jin Ju Park, Ji Eun Kim, Woo Bin Yun, Mi Rim Lee, Jun Young Choi, Bo Ram Song, Hong Joo Son, Yong Lim, Hyun‑Gu Kang, Beum Soo An, Seung Yun Yang, Sung Baek Seo, Dae Youn Hwang

Pages: 452-460 Published online on: 19 November 2018
Open Access

MEK inhibition prevents TGF‑β1‑induced myofibroblast transdifferentiation in human tenon fibroblasts

Jiamin Wen, Xianchai Lin, Wuyou Gao, Bo Qu, Yunlan Ling, Rongjiao Liu, Minbin Yu

Pages: 468-476 Published online on: 20 November 2018
Open Access

Meta‑analysis of current chemotherapy regimens in advanced pancreatic cancer to prolong survival and reduce treatment‑associated toxicities

Jie Chen, Linli Chen, Jianping Yu, Yanmei Xu, Xiaohui Wang, Ziqian Zeng, Ning Liu, Fan Xu, Shu Yang

Pages: 477-489 Published online on: 09 November 2018
Open Access

Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice

Yuzhu Cheng, Zhanlun Ou, Qingguo Li, Juan Yang, Min Hu, Yubin Zhou, Xiaodong Zhuang, Zhenyu Jason Zhang, Shixia Guan

Pages: 490-498 Published online on: 23 November 2018
Open Access

Function of BRD4 in the pathogenesis of high glucose‑induced cardiac hypertrophy

Qian Wang, Yuxin Sun, Tianshu Li, Lianqin Liu, Yunxia Zhao, Liyuan Li, Ling Zhang, Yan Meng

Pages: 499-507 Published online on: 21 November 2018
Open Access

miR‑1271‑5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2

Xiaohe Chen, Shouhang Yang, Jue Zeng, Ming Chen

Pages: 508-514 Published online on: 21 November 2018

SKA2 mediates invasion and metastasis in human breast cancer via EMT

Zhouhui Ren, Tong Yang, Pingping Zhang, Kaitai Liu, Weihong Liu, Ping Wang

Pages: 515-523 Published online on: 02 November 2018

HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma

Li Dong, Liying Xue, Cuiying Zhang, Hui Li, Zhihui Cai, Ruifang Guo

Pages: 524-532 Published online on: 19 November 2018

Knockdown of P120 catenin aggravates endothelial injury under an impinging flow by inducing breakdown of adherens junctions

Jian‑Lan Zhao, Zhi‑Peng Xiao, Nian‑Zu Yu, Jin‑Wen Jiang, Mei‑Hua Li

Pages: 541-548 Published online on: 13 November 2018

Dynamic Nestin expression during hair follicle maturation and the normal hair cycle

Ruosi Chen, Yong Miao, Zhiqi Hu

Pages: 549-554 Published online on: 26 November 2018

Nicotinamide induces liver regeneration and improves liver function by activating SIRT1

Hai‑Feng Wan, Jia‑Xin Li, Hao‑Tian Liao, Ming‑Heng Liao, Lin Luo, Lin Xu, Ke‑Fei Yuan, Yong Zeng

Pages: 555-562 Published online on: 22 November 2018

(+)‑pinoresinol‑O‑β‑D‑glucopyranoside from Eucommia ulmoides Oliver and its anti‑inflammatory and antiviral effects against influenza A (H1N1) virus infection

Jing Li, Xiaoli Liang, Beixian Zhou, Xiaowei Chen, Peifang Xie, Haiming Jiang, Zhihong Jiang, Zifeng Yang, Xiping Pan

Pages: 563-572 Published online on: 26 November 2018

Aortic constriction induces hypertension and cardiac hypertrophy via (pro)renin receptor activation and the PLC‑β3 signaling pathway

Junyan Wu, Cong Zhang, Chuanjun Liu, Aihua Zhang, An Li, Jingjun Zhang, Yanling Zhang

Pages: 573-580 Published online on: 13 November 2018

miR‑494‑3p promotes the progression of endometrial cancer by regulating the PTEN/PI3K/AKT pathway

Lichao Zhu, Xiaoyan Wang, Tao Wang, Wenwen Zhu, Xinge Zhou

Pages: 581-588 Published online on: 13 November 2018

Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Qing Luo, Xue Li, Lu Zhang, Fangyi Yao, Zhen Deng, Cheng Qing, Rigu Su, Jianqing Xu, Yang Guo, Zikun Huang, Junming Li

Pages: 589-594 Published online on: 08 November 2018

CLCN7 and TCIRG1 mutations in a single family: Evidence for digenic inheritance of osteopetrosis

Yongjia Yang, Weihua Ye, Jihong Guo, Liu Zhao, Ming Tu, Yu Zheng, Liping Li

Pages: 595-600 Published online on: 13 November 2018

Epithelial‑mesenchymal transition phenotype of circulating tumor cells is associated with distant metastasis in patients with NSCLC

Xiaochen Zhang, Liyuan Wei, Jun Li, Jing Zheng, Shirong Zhang, Jianying Zhou

Pages: 601-608 Published online on: 21 November 2018

Conditioned medium from human palatine tonsil mesenchymal stem cells attenuates acute graft‑vs.‑host disease in mice

Kyung‑Ah Cho, Yu‑Hee Kim, Minhwa Park, Hye Ji Kim, So‑Youn Woo, Joo‑Won Park, Kyung‑Ha Ryu

Pages: 609-616 Published online on: 13 November 2018

Magnetization transfer contrast MRI in GFP‑tagged live bacteria

Valeria Righi, Melissa Starkey, George Dai, Laurence G. Rahme, Aria A. Tzika

Pages: 617-621 Published online on: 19 November 2018

MicroRNA‑409 may function as a tumor suppressor in endometrial carcinoma cells by targeting Smad2

Chunhua Zhang, Bo Wang, Ling Wu

Pages: 622-628 Published online on: 12 November 2018

Inhibition of lactate dehydrogenase A suppresses inflammatory response in RAW 264.7 macrophages

Yoo‑Jeong Song, Ahyeon Kim, Goon‑Tae Kim, Han Young Yu, Eun‑So Lee, Mi Jin Park, Young‑Jun Kim, Soon‑Mi Shim, Tae‑Sik Park

Pages: 629-637 Published online on: 20 November 2018

Characterization of circRNA‑associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation

Yangyang Zhang, Xianting Ke, Jingjing Liu, Xiue Ma, Yi Liu, Dandan Liang, Luxin Wang, Changfa Guo, Yiwei Luo

Pages: 638-650 Published online on: 26 November 2018

UBIAD1 expression is associated with cardiac hypertrophy in spontaneously hypertensive rats

Bingju Yan, Jun Wang

Pages: 651-659 Published online on: 26 November 2018

Involvement of endothelial nitric oxide synthase pathway in IGF‑1 protects endothelial progenitor cells against injury from oxidized LDLs

Hao‑Jing Wen, Guo‑Feng Liu, Li‑Zhi Xiao, Yong‑Gang Wu

Pages: 660-666 Published online on: 08 November 2018

Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells

Wanzhen Jiao, Jiafu Ji, Fengjiao Li, Jianlian Guo, Yuanjie Zheng, Shangbin Li, Wenwen Xu

Pages: 667-677 Published online on: 09 November 2018

Salidroside prevents diabetes‑induced cognitive impairment via regulating the Rho pathway

Xiuzhen Hao, Jie Yuan, Huixiao Dong

Pages: 678-684 Published online on: 02 November 2018

Long non‑coding RNA Fer‑1‑like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo

Xinyi Sun, Guoqi Zheng, Chunying Li, Chendi Liu

Pages: 685-692 Published online on: 07 November 2018

MicroRNA‑495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma

Longkun Lv, Qiang Wang, Yucheng Yang, Honghai Ji

Pages: 693-702 Published online on: 01 November 2018

IL‑18 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NF‑κB signaling

Fang Wang, Min Guan, Liting Wei, Hui Yan

Pages: 703-710 Published online on: 26 November 2018

MicroRNA‑663 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells by directly targeting PAK4

Yingying Liu, Dan Jiao, Zhen Tian

Pages: 711-718 Published online on: 13 November 2018

MicroRNA‑584 directly targets CCND1 and inhibits cell proliferation and invasion in pancreatic cancer

Gang Chen, Ming Hu, Xiusheng Qu, Kaifeng Wang, Yikun Qu

Pages: 719-726 Published online on: 13 November 2018

Correlation of LOX‑5 and COX‑2 expression with inflammatory pathology and clinical features of adenomyosis

Caixia Li, Rong Chen, Caixia Jiang, Li Chen, Zhongping Cheng

Pages: 727-733 Published online on: 01 November 2018

MicroRNA‑940 promotes cell proliferation and invasion of glioma by directly targeting Kruppel‑like factor 9

Dongzi Zhang, Puheng Hao, Lin Jin, Yuangang Wang, Zhifeng Yan, Shuqiang Wu

Pages: 734-742 Published online on: 07 November 2018

L-carnitine ameliorates peripheral neuropathy in diabetic mice with a corresponding increase in insulin‑like growth factor‑1 level

Rui Wang, Liuxin Wang, Caishun Zhang, Yan Zhang, Yuan Liu, Limin Song, Ruixia Ma, Jing Dong

Pages: 743-751 Published online on: 13 November 2018
Journal Cover

January 2019
Volume 19 Issue 1

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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