Journal Articles

Open Access

Roles of endoplasmic reticulum stress and autophagy on H2O2‑induced oxidative stress injury in HepG2 cells

Zhiming Wu, Huangen Wang, Sunyang Fang, Chaoyang Xu

Pages: 4163-4174 Published online on: 03 September 2018
Open Access

Anti‑breast cancer activity of selected 1,3,5‑triazines via modulation of EGFR‑TK

Weixin Yan, Yiyang Zhao, Jianrong He

Pages: 4175-4184 Published online on: 24 August 2018
Open Access

Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma

Lingqi Zhou, Hai Tang, Fang Wang, Lizhi Chen, Shanshan Ou, Tong Wu, Jie Xu, Kaihua Guo

Pages: 4185-4196 Published online on: 21 August 2018
Open Access

Network analysis of membranous glomerulonephritis based on metabolomics data

Amir Taherkhani, Shiva Kalantari, Afsaneh Arefi Oskouie, Mohsen Nafar, Mohammad Taghizadeh, Koorosh Tabar

Pages: 4197-4212 Published online on: 12 September 2018
Open Access

Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Bin Yuan

Pages: 4213-4218 Published online on: 10 September 2018
Open Access

Protective effects of α‑2‑macroglobulin on human bone marrow mesenchymal stem cells in radiation injury

Yang Liu, Wanting Cao, Xiangbo Kong, Jie Li, Xueying Chen, Yaping Ge, Wanzhen Zhong, Silian Fang

Pages: 4219-4228 Published online on: 04 September 2018
Open Access

Comprehensive analysis of multi Ewing sarcoma microarray datasets identifies several prognosis biomarkers

Xuqing Yin, Jiubo Sun, Haiyang Zhang, Shuai Wang

Pages: 4229-4238 Published online on: 03 September 2018
Open Access

Distribution and prognostic value of tumor‑infiltrating T cells in breast cancer

Shaoda Meng, Li Li, Meiling Zhou, Wanjie Jiang, Heng Niu, Kunxian Yang

Pages: 4247-4258 Published online on: 05 September 2018
Open Access

BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway

Ying‑Bin Wang, Jian‑Qin Xie, Wei Liu, Rong‑Zhi Zhang, Sheng‑Hui Huang, Yan‑Hong Xing

Pages: 4259-4270 Published online on: 04 September 2018
Open Access

Genetic mutation of familial dilated cardiomyopathy based on next‑generation semiconductor sequencing

Xin‑Fu Lin, Jie‑Wei Luo, Gui Liu, Yao‑Bin Zhu, Zhao Jin, Xing Lin

Pages: 4271-4280 Published online on: 05 September 2018
Open Access

Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation

Younju Lee, Jinuk Na, Myung Sun Lee, Eun Young Cha, Ji Young Sul, Jun Beom Park, Jin Sun Lee

Pages: 4281-4288 Published online on: 14 September 2018
Open Access

Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis

Xinyu Hu, Shanshan Teng, Jiawei He, Xiaoqi Sun, Mingzhao Du, Ling Kou, Xiaofeng Wang

Pages: 4289-4296 Published online on: 13 September 2018
Open Access

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease

Chunshuang Xu, Guili Liu, Huihui Ji, Weihua Chen, Dongjun Dai, Zhongming Chen, Dongsheng Zhou, Lei Xu, Haochang Hu, Wei Cui, Lan Chang, Qin Zha, Liping Li, Shiwei Duan, Qinwen Wang

Pages: 4297-4302 Published online on: 24 August 2018
Open Access

Effect of emodin on T cell subsets in NOD mice with NaI‑induced experimental autoimmune thyroiditis

Huaqin Sun, Zhipeng Ye, Ning Li, Fa Jin, Jiuliang Yan, Keren Wu

Pages: 4303-4312 Published online on: 03 September 2018
Open Access

Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization

Biao Ma, Yang Yang, Zhituo Li, Dali Zhao, Weihui Zhang, Yanfeng Jiang, Dongbo Xue

Pages: 4313-4320 Published online on: 14 September 2018
Open Access

Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide‑exposed cells

Xian Wu, Wei Zhou, Qingshuang Wei, Peng Chen, Yan Li

Pages: 4321-4327 Published online on: 14 September 2018
Open Access

Protein phosphatase 2A regulates the p38 signaling pathway to affect the migration of astrocytes

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Jianhua Zhao, Sibei Ji

Pages: 4328-4334 Published online on: 24 August 2018
Open Access

Deletion of poly(ADP‑ribose) polymerase-1 changes the composition of the microbiome in the gut

András Vida, Gábor Kardos, Tünde Kovács, Balázs L. Bodrogi, Péter Bai

Pages: 4335-4341 Published online on: 10 September 2018
Open Access

Amino acid starvation promotes podocyte autophagy through mammalian target of rapamycin inhibition and transcription factor EB activation

Yuanhan Chen, Xingchen Zhao, Jiaxin Li, Li Zhang, Ruizhao Li, Hong Zhang, Ruyi Liao, Shuangxin Liu, Wei Shi, Xinling Liang

Pages: 4342-4348 Published online on: 03 September 2018
Open Access

Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes

Hangyu Tian, Dan Yu, Yan Hu, Pan Zhang, Yang Yang, Qiang Hu, Ming Li

Pages: 4349-4355 Published online on: 04 September 2018
Open Access

Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer

Xi Liu, Xiaodong Wei, Wei Niu, Dong Wang, Bo Wang, Hao Zhuang

Pages: 4356-4364 Published online on: 07 September 2018
Open Access

Molecular pathogenesis involved in human idiopathic pulmonary fibrosis based on an integrated microRNA‑mRNA interaction network

Lijing Wang, Wei Huang, Lemeng Zhang, Qiong Chen, Hongjun Zhao

Pages: 4365-4373 Published online on: 05 September 2018
Open Access

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways

Yongyang Tian, Hong Yin, Xi Deng, Beichuan Tang, Xianjun Ren, Tao Jiang

Pages: 4374-4380 Published online on: 03 September 2018
Open Access

Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells

Xi Wang, Hui Chen, Yiping Wen, Xiaoxin Yang, Qing Han, Ping Jiang, Zaiju Huang, Jing Cai, Zehua Wang

Pages: 4381-4387 Published online on: 04 September 2018
Open Access

Streptozotocin‑induced diabetic mice exhibit reduced experimental choroidal neovascularization but not corneal neovascularization

Gaoqin Liu, Lei Chen, Qinhua Cai, Hongya Wu, Zhigang Chen, Xueguang Zhang, Peirong Lu

Pages: 4388-4398 Published online on: 03 September 2018
Open Access

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

Dandan Li, Weiying Ren, Zhilong Jiang, Lei Zhu

Pages: 4399-4409 Published online on: 24 August 2018
Open Access

Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion

Hui‑Li Yang, Kai‑Kai Chang, Jie Mei, Wen‑Jie Zhou, Li‑Bing Liu, Li Yao, Yi Meng, Ming‑Yan Wang, Si‑Yao Ha, Zhen‑Zhen Lai, Jiang‑Feng Ye, Da‑Jin Li, Ming‑Qing Li

Pages: 4410-4416 Published online on: 24 August 2018
Open Access

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation

Wen‑Bo Yu, Liang Cao, Yan‑Yin Zhao, Wei Xiao, Bao‑Guo Xiao

Pages: 4417-4427 Published online on: 04 September 2018
Open Access

FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease

Xiaotong Wang, Xiaopeng Cui, Chuanwu Zhu, Ming Li, Juan Zhao, Zhongyi Shen, Xiaohang Shan, Liang Wang, Han Wu, Yanting Shen, You Ni, Dongmei Zhang, Guoxiong Zhou

Pages: 4428-4438 Published online on: 14 September 2018
Open Access

Two Paired Box 6 mutations identified in Chinese patients with classic congenital aniridia and cataract

Ying Lin, Hongbin Gao, Yi Zhu, Chuan Chen, Tao Li, Bingqian Liu, Cancan Lyu, Ying Huang, Haichun Li, Qingxiu Wu, Chenjin Jin, Xiaoling Liang, Xinhua Huang, Lin Lu

Pages: 4439-4445 Published online on: 10 September 2018
Open Access

Using Illumina Infinium HumanMethylation 450K BeadChip to explore genome‑wide DNA methylation profiles in a human hepatocellular carcinoma cell line

Ning Sun, Jialin Zhang, Chengshuo Zhang, Yue Shi, Bochao Zhao, Ao Jiao, Baomin Chen

Pages: 4446-4456 Published online on: 03 September 2018
Open Access

Adoptive transfer of xenoantigen‑stimulated T cell receptor Vβ‑restricted human regulatory T cells prevents porcine islet xenograft rejection in humanized mice

Xi Jin, Min Hu, Lina Gong, Huifang Li, Yan Wang, Ming Ji, Hong Li

Pages: 4457-4467 Published online on: 10 September 2018
Open Access

Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms

Xueyan Chen, Huicai Guo, Qing Li, Yu Zhang, Huanlong Liu, Xiaofei Zhang, Kerang Xie, Zhongning Zhu, Qingfeng Miao, Suwen Su

Pages: 4468-4476 Published online on: 12 September 2018
Open Access

Platelet‑rich fibrin exudate promotes the proliferation and osteogenic differentiation of human periodontal ligament cells in vitro

Xiaoju Li, Huixiao Yang, Zijiian Zhang, Zhonghai Yan, Huling Lv, Yan Zhang, Bin Wu

Pages: 4477-4485 Published online on: 10 September 2018
Open Access

Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats

Yu Wang, Xiaofeng Wang, Wei Liu, Lichun Zhang

Pages: 4486-4498 Published online on: 03 September 2018
Open Access

Identification of key genes and associated pathways in KIT/PDGFRA wild‑type gastrointestinal stromal tumors through bioinformatics analysis

Wen‑Jie Wang, Hong‑Tao Li, Jian‑Ping Yu, Yu‑Min Li, Xiao‑Peng Han, Peng Chen, Wen‑Wen Yu, Wei‑Kai Chen, Zuo‑Yi Jiao, Hong‑Bin Liu

Pages: 4499-4515 Published online on: 05 September 2018
Open Access

Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury

Xiaoli Niu, Simin Zheng, Hongtao Liu, Siyuan Li

Pages: 4516-4522 Published online on: 06 September 2018
Open Access

Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia‑reperfusion

Bing Wang, Hua Xu, Jian Li, Hong‑Mei Gao, Ying‑Hong Xing, Zhu Lin, Hong‑Jie Li, Yong‑Qiang Wang, Shu‑Hua Cao

Pages: 4523-4529 Published online on: 14 September 2018

Aldehyde dehydrogenase activity in cryopreserved cord blood cells for quality assessment prior to transplantation

Junko Ikemoto, Satoshi Yoshihara, Tamami Kobayashi, Shunro Kai, Yoshihiro Fujimori

Pages: 4530-4534 Published online on: 13 September 2018

Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway

Yinqiang Xin, Peiling Ben, Qi Wang, Yanyan Zhu, Zhimin Yin, Lan Luo

Pages: 4535-4542 Published online on: 05 September 2018

Expression and clinical significance of ubiquitin‑specific‑processing protease 34 in diffuse large B‑cell lymphoma

Chunyao Li, Lanshan Huang, Huiping Lu, Wei Wang, Gang Chen, Yongyao Gu, Qianping Zhou, Zhigang Peng, Zhenbo Feng

Pages: 4543-4554 Published online on: 03 September 2018

Epigallocatechin‑3‑gallate protects against secondary osteoporosis in a mouse model via the Wnt/β‑catenin signaling pathway

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Jinlong Li, Lixin Guo, Haibin Xue, Guangsen Wu

Pages: 4555-4562 Published online on: 03 September 2018

miRNA‑328 overexpression confers cisplatin resistance in non‑small cell lung cancer via targeting of PTEN

Chunmei Wang, Shijun Wang, Feng'e Ma, Weidan Zhang

Pages: 4563-4570 Published online on: 12 September 2018

Silencing of perilipin by short hairpin RNA inhibits proliferation and induces apoptosis in liposarcoma cells

Ling‑Xin Meng, Yu‑Xiu Zheng, Mao‑Lei He, Xiao‑Ming Zhou, Shu‑Yan Sun, Zhao‑Jun Ding, Qin Meng, Bing‑Cheng Li, Yan‑Wei Sun

Pages: 4571-4576 Published online on: 05 September 2018

Protection of insulin‑like growth factor 1 on experimental peripheral neuropathy in diabetic mice

Hua Wang, Hao Zhang, Fuming Cao, Jiaping Lu, Jin Tang, Huizhi Li, Yiyun Zhang, Bo Feng, Zhaosheng Tang

Pages: 4577-4586 Published online on: 03 September 2018

Bafilomycin A1 alleviates depression‑like symptoms in chronic unpredictable mild stress rats

Zhijian Wang, Shengbing Liu, Weiwei Pan, Yanjun Guo, Zhongfei Shen

Pages: 4587-4594 Published online on: 03 September 2018

Huwe1 is a novel mediator of protection of neural progenitor L2.3 cells against oxygen‑glucose deprivation injury

Xiaoqin Jiang, Jiyun Yang, Hedong Li, Yi Qu, Wenming Xu, Haiyan Yu, Yu Tong

Pages: 4595-4602 Published online on: 03 September 2018

Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway

Zhen Mu, Qing Sun

Pages: 4603-4610 Published online on: 03 September 2018

Analysis of virulence diversity of 73 Helicobacter pylori strains isolated in Guizhou province, China

Lin Yin, Fang Liu, Changcheng Guo, Qiong Wang, Ke Pan, Liangbi Xu, Yan Xiong, Yingting Chen, Zhenghong Chen

Pages: 4611-4620 Published online on: 05 September 2018

Association between the methylation of six apoptosis‑associated genes with autism spectrum disorder

Yuanzhi Zhao, Cong Zhou, Hang Yu, Wenwu Zhang, Fang Cheng, Haihang Yu, Dongsheng Zhou, Bin Li, Jing Liu, Jie Dai, Jie Zhong, Min Chen, Tianyi Huang, Ranran Pan, Shiwei Duan, Zhenyu Hu

Pages: 4629-4634 Published online on: 10 September 2018

Inhibition of CCL19 benefits non‑alcoholic fatty liver disease by inhibiting TLR4/NF‑κB‑p65 signaling

Jiajing Zhao, Yingjue Wang, Xi Wu, Ping Tong, Yaohan Yue, Shurong Gao, Dongping Huang, Jianwei Huang

Pages: 4635-4642 Published online on: 14 September 2018

Application of medical adhesive inhibits intimal hyperplasia involving the downregulation of ERK1/2 and eNOS levels

Shoudong Chai, Yang Yu, Haiming Li, Mingxin Gao, Bo Li , Chengxiong Gu

Pages: 4643-4649 Published online on: 17 September 2018

Post‑transplant lymphoproliferative disorder in hematopoietic stem cell transplant patients: A single center retrospective study between 2005 and 2012

Joana Marinho‑Dias, João Lobo, Rui Henrique, Inês Baldaque, Carlos Pinho‑Vaz, Luísa Regadas, Rosa Branca, Fernando Campilho, António Campos Jr, Rui Medeiros, Hugo Sousa

Pages: 4650-4656 Published online on: 03 September 2018

Sevoflurane‑induced neurotoxicity is driven by OXR1 post‑transcriptional downregulation involving hsa‑miR‑302e

Leilei Yang, Qian Shen, Yanqiong Xia, Xueheng Lei, Jian Peng

Pages: 4657-4665 Published online on: 03 September 2018

Attenuated endothelial function is associated with decreased endothelial progenitor cells and nitric oxide in premenopausal diabetic women

Juan Liu, Da‑Jun Hu, Huiyang Yan, Jianbin Liu, Xixong Ai, Zi Ren, Haitao Zeng, Hao He, Zhen Yang

Pages: 4666-4674 Published online on: 04 September 2018

Ursolic acid alleviates inflammation and against diabetes‑induced nephropathy through TLR4‑mediated inflammatory pathway

Jian Li, Nan Li, Shuangtong Yan, Minyan Liu, Banruo Sun, Yanhui Lu, Yinghong Shao

Pages: 4675-4681 Published online on: 03 September 2018

SFRP5 serves a beneficial role in arterial aging by inhibiting the proliferation, migration and inflammation of smooth muscle cells

Jiadela Teliewubai, Hongwei Ji, Yuyan Lu, Bin Bai, Shikai Yu, Chen Chi, Yawei Xu, Yi Zhang

Pages: 4682-4690 Published online on: 07 September 2018

Molecular mechanisms regarding potassium bromate‑induced cardiac hypertrophy without apoptosis in H9c2 cells

Shu‑Chun Kuo, Yingxiao Li, Yung‑Ze Cheng, Wei‑Jing Lee, Juei‑Tang Cheng, Kai‑Chun Cheng

Pages: 4700-4708 Published online on: 10 September 2018

Structure‑activity associations in novel farrerol derivatives with vasorelaxant properties

Xiaomin Hou, Xiaojiang Qin, Qingshan Li

Pages: 4709-4715 Published online on: 03 September 2018

Sarcomatoid carcinoma of the pancreas: A case report and review of the literature

Yingjun Xie, Yien Xiang, Dan Zhang, Xiaoxiao Yao, Jiyao Sheng, Yongsheng Yang, Xuewen Zhang

Pages: 4716-4724 Published online on: 14 September 2018

Acute stimulatory effect of tumor necrosis factor on the basolateral 50 pS K channels in the thick ascending limb of the rat kidney

Guoyan Zhang, Shiliang Gui, Weiqun Wang, Dexin Meng, Qingmin Meng, Haiyan Luan, Rixin Zhao, Jiatian Zhang, Hongyu Sui

Pages: 4733-4738 Published online on: 10 September 2018

Silencing of pantothenate kinase 2 reduces endothelial cell angiogenesis

Francesca Pagani, Akansha Trivedi, Deepak Khatri, Daniela Zizioli, Emirena Garrafa, Stefania Mitola, Dario Finazzi

Pages: 4739-4746 Published online on: 13 September 2018

miR‑501‑3p sensitizes glioma cells to cisplatin by targeting MYCN

Chuan‑Gang Zhang, Fan Yang, Yan‑Hua Li, Yan Sun, Xue‑Jian Liu, Xia Wu

Pages: 4747-4752 Published online on: 05 September 2018

Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways

Jiancheng Xi, Qinggui Li, Xiaobo Luo, Yipeng Wang, Jinlong Li, Lixin Guo, Guangsen Wu

Pages: 4753-4759 Published online on: 03 September 2018

LIMD2 targeted by miR‑34a promotes the proliferation and invasion of non‑small cell lung cancer cells

Fei Wang, Zhaoguo Li, Lei Xu, Yongchao Li, Yi Li, Xingbo Zhang, Yue Wang, Dazhong Liu

Pages: 4760-4766 Published online on: 06 September 2018
Open Access

[Retracted] BIRC5 is a novel target of peroxisome proliferator‑activated receptor γ in brain microvascular endothelium cells during cerebral ischemia

Mingjing Xu, Xianli Yang, Qing Zeng, He He, Pengcheng Lu, Guozhi Huang

Pages: 4767-4767 Published online on: 22 August 2018
Open Access

[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis

Haiying Shen, Kiyoon Kim, Yoojung Oh, Kyung Sik Yoon, Hyung Hwan Baik, Sung Soo Kim, Joohun Ha, Insug Kang, Wonchae Choe

Pages: 4768-4768 Published online on: 12 September 2018
Journal Cover

November 2018
Volume 18 Issue 5

Print ISSN: 1791-2997
Online ISSN: 1791-3004

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