Journal Articles

Open Access

Biology and pathogenesis of human osteosarcoma (Review)

Judson Welber Veríssimo de Azevedo, Thales Allyrio Araújo de Medeiros Fernandes, José Veríssimo Fernandes, Jenner Chrystian Veríssimo de Azevedo, Daniel Carlos Ferreira Lanza, Christiane Medeiros Bezerra, Vânia Sousa Andrade, Josélio Maria Galvão de Araújo, José Veríssimo Fernandes

Pages: 1099-1116 Published online on: 18 December 2019
Open Access

Role of Gd2O3‑doped carbon‑11‑choline‑lenvatinib nanoparticles contrast agent PET/CT in the diagnosis of patients with lung cancer

Tong Zhou, Dongfang Hang, Ying Li, Jin Zhang, Huayang Wu, Hongyan Wang, Enbing Tian, Jun Yan

Pages: 1117-1124 Published online on: 23 December 2019
Open Access

Molecular cytogenetic pilot study on pleomorphic adenomas of salivary glands

Jovanna Thielker, Anja Weise, Moneeb A.K. Othman, Isabel M. Carreria, Joana B. Melo, Ferdinand von Eggeling, Orlando Guntinas‑Lichius, Monika Ziegler, Thomas Liehr

Pages: 1125-1130 Published online on: 10 December 2019
Open Access

Long non‑coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1

Taicheng Zhou, Lili Wu, Zhen Zong, Ning Ma, Yingru Li, Zhipeng Jiang, Qirui Wang, Shuang Chen

Pages: 1131-1136 Published online on: 09 December 2019
Open Access

Targeted molecular profiling of genetic alterations in colorectal cancer using next‑generation sequencing

Jia Luo, Shengjun Zhang, Meihua Tan, Jia Li, Huadong Xu, Yanfei Tan, Yue Huang

Pages: 1137-1144 Published online on: 10 December 2019
Open Access

Effect of dexmedetomidine on the cognitive function of patients undergoing gastric cancer surgery by regulating the PI3K/AKT signaling pathway

Zhiyuan Wang, Zijin Shen, Haibin Wang, Lin Zhang, Rong Dong

Pages: 1151-1156 Published online on: 18 December 2019
Open Access

Downregulation of LINC01140 is associated with adverse features of breast cancer

Deheng Li, Liangdong Li, Yiqun Cao, Xin Chen

Pages: 1157-1164 Published online on: 25 November 2019
Open Access

Time‑series clustering of cytokine expression after transarterial chemoembolization in patients with hepatocellular carcinoma

Feng Qi, Lingxiao Wang, Peixin Huang, Zhiying Zhao, Biwei Yang, Jinglin Xia

Pages: 1175-1186 Published online on: 11 December 2019
Open Access

Effects of miR‑129‑3p on biological functions of prostate cancer cells through targeted regulation of Smad3

Yunpeng Jia, Yu Gao, Jianguo Dou

Pages: 1195-1202 Published online on: 13 December 2019
Open Access

Effects of hub genes on the clinicopathological and prognostic features of lung adenocarcinoma

Dong‑Hu Yu, Jing‑Yu Huang, Xiao‑Ping Liu, Xiao‑Lan Ruan, Chen Chen, Wei‑Dong Hu, Sheng Li

Pages: 1203-1214 Published online on: 09 December 2019
Open Access

Identification of osteosarcoma driver genes using a network method

Zebing Si , Konghe Hu

Pages: 1215-1222 Published online on: 12 December 2019
Open Access

PD‑L1 gene promoter methylation represents a potential diagnostic marker in advanced gastric cancer

Dan Lv, Chengjuan Xing, Lin Cao, Yuejian Zhuo, Tao Wu, Na Gao

Pages: 1223-1234 Published online on: 16 December 2019
Open Access

Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer

Peng Chen, Youmei Wang, Xiaosan Fang, Xiaoming Wang, Guannan Wang

Pages: 1235-1240 Published online on: 04 December 2019
Open Access

BMP4 induces asymmetric cell division in human glioma stem-like cells

Motofumi Koguchi, Yukiko Nakahara, Hiroshi Ito, Tomihiro Wakamiya, Fumitaka Yoshioka, Atsushi Ogata, Kohei Inoue, Jun Masuoka, Hideki Izumi, Tatsuya Abe

Pages: 1247-1254 Published online on: 20 December 2019
Open Access

Long non‑coding RNA TTN‑AS1 promotes breast cancer cell migration and invasion via sponging miR‑140‑5p

Jie Xue, Zhixia Zhang, Xiaona Li, Qingfang Ren, Qinghua Wang

Pages: 1255-1260 Published online on: 17 December 2019
Open Access

Regulation of lncRNA PVT1 on miR-125 in metastasis of gastric cancer cells

Jiatai Niu, Xiangxin Song, Xiaomei Zhang

Pages: 1261-1266 Published online on: 10 December 2019
Open Access

lncRNA PVT1 accelerates progression of non‑small cell lung cancer via targeting miRNA‑526b/EZH2 regulatory loop

Chun Qiu, Sai Li, Datong Sun, Shenghui Yang

Pages: 1267-1272 Published online on: 20 December 2019
Open Access

Expression of miR‑34a and Ki67 in nasopharyngeal carcinoma and the relationship with clinicopathological features and prognosis

Linqi Wei, Chao Shi, Yonghong Zhang

Pages: 1273-1280 Published online on: 13 December 2019
Open Access

Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer

Yakun Hu, Yuchen Yan, Yang Xu, He Yang, Lisha Fang, Yongli Liu, Xin Li, Qiang Li, Hongchao Yan

Pages: 1281-1290 Published online on: 12 December 2019
Open Access

Bone morphogenic proteins‑2, ‑4, ‑6 and 7 in non‑muscle invasive bladder cancer

Tvrtko Hudolin, Zeljko Kastelan, Ahmad El‑Saleh, Mirko Bakula, Marijana Coric, Petar Kes, Davor Tomas, Nikolina Basic‑Jukic

Pages: 1291-1297 Published online on: 13 December 2019
Open Access

Involvement of the TGF-β1 pathway in caveolin-1-associated regulation of head and neck tumor cell metastasis

Jinjie Sun, Yongtian Lu, Changyun Yu, Ting Xu, Guohui Nie, Beiping Miao, Xin Zhang

Pages: 1298-1304 Published online on: 06 December 2019
Open Access

mi‑R4435‑2HG promotes proliferation and inhibits apoptosis of cancer cells in ovarian carcinoma by upregulating ROCK2

Jinghui Hu, Li Wang, Wei Zhao, Yujie Huang, Zhe Wang, Heping Shen

Pages: 1305-1309 Published online on: 11 December 2019
Open Access

Influence of miR‑101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway

Xuan Meng, Yong Shi, Xin Xiang, Chonghui Li, Xinlan Ge, Ke Pan, Yurong Liang

Pages: 1310-1316 Published online on: 12 December 2019
Open Access

Evaluation of azacitidine in patients with transplant‑ineligible myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia‑related changes in a Japanese clinical setting

Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Ryo Saito, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura

Pages: 1317-1321 Published online on: 18 December 2019
Open Access

IDH1‑R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR

Narui Yin, Ting Xie, Haowen Zhang, Jian Chen, Jiahua Yu, Fenju Liu

Pages: 1322-1330 Published online on: 25 November 2019
Open Access

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer

Yuhao Men, Ling Li, Fen Zhang, Xueyuan Kong, Weidong Zhang, Chongli Hao, Guotian Wang

Pages: 1331-1337 Published online on: 11 December 2019
Open Access

Glucose restriction combined with chemotherapy decreases telomere length and cancer antigen‑125 secretion in ovarian carcinoma

Stephanie Antoun, David Atallah, Roula Tahtouh, Mona Diab Assaf, Malak Moubarak, Eliane Nasser Ayoub, Georges Chahine, George Hilal

Pages: 1338-1350 Published online on: 20 December 2019
Open Access

A novel risk score model for stomach adenocarcinoma based on the expression levels of 10 genes

Encui Guan, Feng Tian, Zhaoxia Liu

Pages: 1351-1367 Published online on: 09 December 2019
Open Access

Centromere protein F and Forkhead box M1 correlation with prognosis of non‑small cell lung cancer

Rui Li, Xia Wang, Xiaoqian Zhao, Xiaohong Zhang, Honghai Chen, Yue Ma, Yandong Liu

Pages: 1368-1374 Published online on: 20 December 2019
Open Access

Integrated bioinformatics analysis to screen hub genes in the lymph node metastasis of thyroid cancer

Si Lu, Rongjie Zhao, Jie Shen, Yu Zhang, Jingjing Shi, Chenke Xu, Jiali Chen, Renbin Lin, Weidong Han, Dingcun Luo

Pages: 1375-1383 Published online on: 06 December 2019
Open Access

A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells

Shi‑Gang Qi, Li‑Qiu Quan, Xiao‑Yue Cui, Hong‑Mei Li, Xu‑Dong Zhao, Rong‑Tao Li

Pages: 1384-1392 Published online on: 23 December 2019
Open Access

Cardamonin as a potential treatment for melanoma induces human melanoma cell apoptosis

Yuyang Yue, Lijuan Liu, Peipei Liu, Yuting Li, Haitao Lu, Yanjia Li, Guoqiang Zhang, Xinsuo Duan

Pages: 1393-1399 Published online on: 23 December 2019
Open Access

TRIM59 as a novel molecular biomarker to predict the prognosis of patients with NSCLC

Ming Lou, Zhaojia Gao, Tao Zhu, Xiaoliang Mao, Yeming Wang, Kai Yuan, Jichun Tong

Pages: 1400-1408 Published online on: 10 December 2019
Open Access

Targeting of TLE3 by miR‑3677 in human breast cancer promotes cell proliferation, migration and invasion

Li‑Na Peng, Xing‑Yan Deng, Xiao‑Xiong Gan, Jin‑Hui Zhang, Guang‑Hui Ren, Fei Shen, Jian‑Hua Feng, Wen‑Song Cai, Bo Xu

Pages: 1409-1417 Published online on: 23 December 2019
Open Access

MicroRNA‑608 promotes apoptosis via BRD4 downregulation in pancreatic ductal adenocarcinoma

Maoyuan Li, Ting Li, Weidong Ma, Xiuchao Wang, Gang Zhao

Pages: 1418-1426 Published online on: 31 December 2019
Open Access

MicroRNA‑519 inhibits hypoxia‑induced tumorigenesis of pancreatic cancer by regulating immune checkpoint PD‑L1

Kate Nong, Dong Zhang, Changze Chen, Yue Yang, Yong Yang, Shengyong Liu, Huihua Cai

Pages: 1427-1433 Published online on: 20 December 2019
Open Access

Bioinformatics analysis of esophageal cancer unveils an integrated mRNA‑lncRNA signature for predicting prognosis

Tian Lan, Zunqiang Xiao, Hua Luo, Kunlun Su, Ouou Yang, Chengni Zhan, Yunyan Lu

Pages: 1434-1442 Published online on: 11 December 2019
Open Access

Survival prediction models for patients with anal carcinoma receiving definitive chemoradiation: A population‑based study

Yinhang Wu, Xiaoyang Han, Yan Li, Kunli Zhu, Jinming Yu

Pages: 1443-1451 Published online on: 23 December 2019
Open Access

Clinical characteristics of malignant melanoma in central China and predictors of metastasis

Ke Shi, Xuran Zhu, Zhongyang Liu, Nan Sun, Luosha Gu, Yang Wei, Xu Cheng, Zewei Zhang, Baihui Xie, Shuaixi Yang, Guangshuai Li, Linbo Liu

Pages: 1452-1464 Published online on: 16 December 2019
Open Access

Long non‑coding RNA expression identified by microarray analysis: Candidate biomarkers in human acral lentiginous melanoma

Hao‑Ze Shi, Jing‑Shu Xiong, Cong‑Cong Xu, Wen‑Bo Bu, Yan Wang, Jian‑Fang Sun, Hao Chen

Pages: 1465-1477 Published online on: 11 December 2019
Open Access

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

Peng Yan, Bin Zhou, Yingdong Ma, Ani Wang, Xiaojun Hu, Youli Luo, Yajun Yuan, Yajun Wei, Pengfei Pang, Junjie Mao

Pages: 1478-1486 Published online on: 20 December 2019
Open Access

Immunohistochemical‑based molecular subtyping of colorectal carcinoma using maspin and markers of epithelial‑mesenchymal transition

Laura Banias, Ioan Jung, Tivadar Bara, Zsolt Fulop, Patricia Simu, Iunius Simu, Catalin Satala, Simona Gurzu

Pages: 1487-1495 Published online on: 18 December 2019
Open Access

Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non‑coding RNAs

Qiongying Zhang, Zhuo Lin, Haiyan Zhang, Xiaodong Bao, Huxiang Zhang

Pages: 1496-1504 Published online on: 20 December 2019
Open Access

lncRNA SNHG7 affects malignant tumor behaviors through downregulation of EZH2 in uveal melanoma cell lines

Xue Wu, Yiqun Yuan, Ruiqi Ma, Binbin Xu, Rui Zhang

Pages: 1505-1515 Published online on: 23 December 2019
Open Access

Inhibition mechanism of lung cancer cell metastasis through targeted regulation of Smad3 by miR‑15a

Shuai Guo, Ming Li, Juan Li, Yan Lv

Pages: 1516-1522 Published online on: 10 December 2019
Open Access

Influence mechanism of miRNA‑144 on proliferation and apoptosis of osteosarcoma cells

Xu Zhang, Zhengwei Li, Wei Ji, Xilong Chen, Qiang Gao, Dajin Li, Haihui Qin

Pages: 1530-1536 Published online on: 10 December 2019
Open Access

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Adina E. Stanciu, Adina Zamfir-Chiru-Anton, Marcel M. Stanciu, Anca Pantea Stoian, Viorel Jinga, Cornelia Nitipir, Alexandru Bucur, Teodora S. Pituru, Andreea L. Arsene, Cristina M. Dragoi, Razvan Hainarosie, Alina C. Nicolae, Mirela Gherghe, Dan C. Gheorghe, Demetrios A. Spandidos, Aristidis Tsatsakis, Maria Papasavva, Nikolaos Drakoulis

Pages: 1537-1543 Published online on: 13 December 2019
Open Access

Intercellular adhesion molecule-1 and S-100β in sevoflurane combined with epidural anesthesia for radical resection of lung cancer

Nan Zhao, Chunyuan Lu, Liang Liu, Peng Sun, Jiange Han

Pages: 1544-1550 Published online on: 30 December 2019

Evaluation of circulating cell‑free DNA as a molecular monitoring tool in patients with metastatic cancer

Clemens Hufnagl, Michael Leisch, Lukas Weiss, Thomas Melchardt, Martin Moik, Daniela Asslaber, Geisberger Roland, Philipp Steininger, Thomas Meissnitzer, Daniel Neureiter, Richard Greil, Alexander Egle

Pages: 1551-1558 Published online on: 09 December 2019

Radiomics predicts survival of patients with advanced non‑small cell lung cancer undergoing PD‑1 blockade using Nivolumab

Valerio Nardone, Paolo Tini, Pierpaolo Pastina, Cirino Botta, Alfonso Reginelli, Salvatore Francesco Carbone, Rocco Giannicola, Grazia Calabrese, Carmela Tebala, Cesare Guida, Aldo Giudice, Vito Barbieri, Pierfrancesco Tassone, Pierosandro Tagliaferri, Salvatore Cappabianca, Rosanna Capasso, Amalia Luce, Michele Caraglia, Maria Antonietta Mazzei, Luigi Pirtoli, Pierpaolo Correale

Pages: 1559-1566 Published online on: 16 December 2019

miR‑519 regulates the proliferation of breast cancer cells via targeting human antigen R

Lili Ren, Yong Li, Qun Zhao, Liqiao Fan, Bibo Tan, Aimin Zang, Hua Yang

Pages: 1567-1576 Published online on: 20 December 2019

Nesfatin‑1 is a potential diagnostic biomarker for gastric cancer

Xiao‑Qing Wang, Yan Zheng, Pei‑Fei Fang, Xian‑Bing Song

Pages: 1577-1583 Published online on: 10 December 2019

High mobility group AT‑hook 2 and c‑MYC as potential prognostic factors in pancreatic ductal adenocarcinoma

Ke Li, Jiali Yang, Jiafei Chen, Yanshu Shi, Zhuoli Zhang, Wei Chen

Pages: 1584-1592 Published online on: 11 December 2019

Inhibition of acetylcholinesterase activity and β‑amyloid oligomer formation by 6‑bromotryptamine A, a multi‑target anti‑Alzheimer's molecule

Xiaofeng Jin, Minjun Wang, Jieyi Shentu, Chunhui Huang, Yujing Bai, Hanbo Pan, Difan Zhang, Zhijun Yuan, Hui Zhang, Xiao Xiao, Xiang Wu, Lijian Ding, Qinwen Wang, Shan He, Wei Cui

Pages: 1593-1601 Published online on: 18 December 2019
Open Access

Application of deep learning to the classification of uterine cervical squamous epithelial lesion from colposcopy images combined with HPV types

Yasunari Miyagi, Kazuhiro Takehara, Yoko Nagayasu, Takahito Miyake

Pages: 1602-1610 Published online on: 12 December 2019
Open Access

Upregulation of contactin‑1 expression promotes prostate cancer progression

Boren Wang, Xi Yang, Ting Zhao, Hanghang Du, Tong Wang, Suping Zhong, Bo Yang, Hui Li

Pages: 1611-1618 Published online on: 23 December 2019
Open Access

Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer

Xuekang Wang, Yanhan Dong, Qiong Wu, Tong Lu, Yuanyong Wang, Wenchao Liu, Chengyu Liu, Wenhua Xu

Pages: 1619-1634 Published online on: 02 January 2020
Journal Cover

February 2020
Volume 19 Issue 2

Print ISSN: 1792-1074
Online ISSN: 1792-1082

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