Journal Articles

Open Access

The Akt pathway in oncology therapy and beyond (Review)

George Mihai Nitulescu, Maryna Van De Venter, Georgiana Nitulescu, Anca Ungurianu, Petras Juzenas, Qian Peng, Octavian Tudorel Olaru, Daniela Grădinaru, Aristides Tsatsakis, Dimitris Tsoukalas, Demetrios A. Spandidos, Denisa Margina

Pages: 2319-2331 Published online on: 16 October 2018

Mechanisms underlying the effects of stress on tumorigenesis and metastasis (Review)

Zhaozhou Zhang, Yan Wang, Qi Li

Pages: 2332-2342 Published online on: 24 September 2018

Interaction of long-chain non-coding RNAs and important signaling pathways on human cancers (Review)

Wei Sun, Ying Shi, Zhifei Wang, Jiye Zhang, Hanhui Cai, Jungang Zhang, Dongsheng Huang

Pages: 2343-2355 Published online on: 27 September 2018
Open Access

Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells

Kaikai Wu, Kun Na, Dian Chen, Yujie Wang, Haitao Pan, Xingya Wang

Pages: 2356-2368 Published online on: 28 September 2018
Open Access

High expression of Copine 1 promotes cell growth and metastasis in human lung adenocarcinoma

Shunlin Liu, Haicheng Tang, Jianjie Zhu, Heguo Ding, Yuanyuan Zeng, Wenwen Du, Zongli Ding, Pengtao Song, Yang Zhang, Zeyi Liu, Jian-An Huang

Pages: 2369-2378 Published online on: 12 September 2018
Open Access

Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression

Mimmo Turano, Valeria Costabile, Andrea Cerasuolo, Francesca Duraturo, Raffaella Liccardo, Paolo Delrio, Ugo Pace, Daniela Rega, Concetta Anna Dodaro, Marco Milone, Paola Izzo, Marina De Rosa

Pages: 2379-2396 Published online on: 18 September 2018
Open Access

Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression

Shuang Zhao, Lisha Wu, Yehong Kuang, Juan Su, Zhongling Luo, Yan Wang, Jinmao Li, Jianglin Zhang, Wangqing Chen, Fangfang Li, Yijing He, Juan Tao, Jianda Zhou, Xiaowei Xu, Cong Peng, Xiang Chen

Pages: 2397-2408 Published online on: 01 October 2018
Open Access

Mst1 regulates non-small cell lung cancer A549 cell apoptosis by inducing mitochondrial damage via ROCK1/F‑actin pathways

Weiqiang Zhang, Keiqiang Liu, Yingxin Pei, Jingbo Ma, Jiang Tan, Jing Zhao

Pages: 2409-2422 Published online on: 08 October 2018
Open Access

Interferon γ suppresses dentin sialophosphoprotein in oral squamous cell carcinoma cells resulting in antitumor effects, via modulation of the endoplasmic reticulum response

Ioannis Gkouveris, Nikolaos G. Nikitakis, Jaya Asservatham, Kalu U.E. Ogbureke

Pages: 2423-2432 Published online on: 10 October 2018
Open Access

miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2

Li-Li Han, Xiao-Ran Yin, Shu-Qun Zhang

Pages: 2433-2444 Published online on: 01 October 2018
Open Access

Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression

Yongtian Yu, Liang Cheng, Bin Yan, Cancan Zhou, Weikun Qian, Ying Xiao, Tao Qin, Junyu Cao, Liang Han, Qingyong Ma, Jiguang Ma

Pages: 2445-2457 Published online on: 26 September 2018
Open Access

GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma

Maria Fernanda Setúbal Destro Rodrigues, Lucyene Miguita, Nathália Paiva De Andrade, Daniele Heguedusch, Camila Oliveira Rodini, Raquel Ajub Moyses, Tatiana Natasha Toporcov, Ricardo Ribeiro Gama, Eloiza Elena Tajara, Fabio Daumas Nunes

Pages: 2458-2472 Published online on: 26 September 2018
Open Access

Prognostic value and potential function of splicing events in prostate adenocarcinoma

Zhi-Guang Huang, Rong-Quan He, Zeng-Nan Mo

Pages: 2473-2487 Published online on: 17 September 2018
Open Access

Cytocidal effects of arenobufagin and hellebrigenin, two active bufadienolide compounds, against human glioblastoma cell line U-87

Lingyu Han, Bo Yuan, Ryota Shimada, Hideki Hayashi, Nan Si, Hai-Yu Zhao, Baolin Bian, Norio Takagi

Pages: 2488-2502 Published online on: 20 September 2018
Open Access

Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression

Yifan Tan, Lei Wang, Yang Du, Xiuheng Liu, Zhiyuan Chen, Xiaodong Weng, Jia Guo, Hui Chen, Min Wang, Xiao Wang

Pages: 2503-2517 Published online on: 27 September 2018
Open Access

Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells

In Hwan Tae, Eun Young Park, Prasanta Dey, Ji Yeon Son, Seok-Yong Lee, Jee H. Jung, Saloni Saloni, Mi-Hyun Kim, Hyung Sik Kim

Pages: 2518-2530 Published online on: 13 September 2018
Open Access

Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma

Chengke Zhang, Yingtao Hao, Licun Wu, Xiaopeng Dong, Ning Jiang, Bo Cong, Jiang Liu, Wen Zhang, Dongqi Tang, Marc De Perrot, Xiaogang Zhao

Pages: 2531-2541 Published online on: 21 September 2018
Open Access

Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma

Shen Sun, Yue Wang, Yue Wu, Yue Gao, Qi Li, Ayanlaja Abiola Abdulrahman, Xin‑Feng Liu, Guang‑Quan Ji, Jin Gao, Li Li, Fa‑Ping Wan, Yun‑Qing Li, Dian‑Shuai Gao

Pages: 2542-2554 Published online on: 21 September 2018
Open Access

Prognostic value of DKK2 from the Dickkopf family in human breast cancer

You-Cheng Shao, Xiao-Cui Nie, Guo-Qing Song, Yan Wei, Pu Xia, Xiao-Yan Xu

Pages: 2555-2565 Published online on: 09 October 2018
Open Access

Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1

Rong Yan, Kang Li, Da-Wei Yuan, Hao-Nan Wang, Yong Zhang, Cheng-Xue Dang, Kun Zhu

Pages: 2566-2578 Published online on: 12 October 2018

Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells

Pei Jou Chua, Jia Pei Lim, Tian Tian Guo, Puja Khanna, Qidong Hu, Boon Huat Bay, Gyeong Hun Baeg

Pages: 2579-2589 Published online on: 11 September 2018

Metastatic cancer cells compensate for low energy supplies in hostile microenvironments with bioenergetic adaptation and metabolic reprogramming

Yunlong Cheng, Yusheng Lu, Doudou Zhang, Shu Lian, Haiyan Liang, Yuying Ye, Ruizhi Xie, Shuhui Li, Jiahang Chen, Xuhui Xue, Jingjing Xie, Lee Jia

Pages: 2590-2604 Published online on: 02 October 2018

Underexpression of α-1-microglobulin/bikunin precursor predicts a poor prognosis in oral squamous cell carcinoma

Shoichi Sekikawa, Takeshi Onda, Nami Miura, Takeshi Nomura, Nobuo Takano, Takahiko Shibahara, Kazufumi Honda

Pages: 2605-2614 Published online on: 01 October 2018

Downregulation of microRNA‑182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation

Yan‑Xia Huang, Xin‑Gang Nie, Guang‑Da Li, Dong‑Sheng Fan, Li‑Li Song, Xin‑Lin Zhang

Pages: 2615-2626 Published online on: 09 October 2018

Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna  Nasreldin, Ramesh Dasari, Matthew Hart, Alexander Kornienko, Jeremy  Just, Jason A. Smith, Alex C. Bissember, Cara B. Gonzales

Pages: 2627-2636 Published online on: 05 October 2018

Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer

Li Ning, Bo Long, Wen Zhang, Mei Yu, Shu Wang, Dongyan Cao, Jiaxin Yang, Keng Shen, Yuenan Huang, Jinghe Lang

Pages: 2637-2646 Published online on: 20 September 2018

Photothermal therapy with AuNRs and EGFRmAb-AuNRs inhibits subcutaneous transplantable hypopharyngeal tumors in nude mice

Yingying Zhang, Jiayan He, Yu Wang, Jinya Wen, Yingying Zou, Zhihong Yang, Xiaoguang He

Pages: 2647-2658 Published online on: 12 September 2018

Establishment of a non‑coding RNAomics screening platform for the regulation of KRAS in pancreatic cancer by RNA sequencing

Li Zhang, Shuangni Yu, Cuiping Wang, Congwei Jia, Zhaohui Lu, Jie Chen

Pages: 2659-2670 Published online on: 13 September 2018

Long non-coding RNA CUDR promotes malignant phenotypes in pancreatic ductal adenocarcinoma via activating AKT and ERK signaling pathways

Xing Liang, Meiyan Qi, Rui Wu, Anan Liu, Danlei Chen, Liang Tang, Jun Chen, Xiangui Hu, Wei Li, Lixing Zhan, Chenghao Shao

Pages: 2671-2682 Published online on: 27 September 2018

An RGD small-molecule integrin antagonist induces detachment-mediated anoikis in glioma cancer stem cells

Mayra Paolillo, Marisa C. Galiazzo, Antonio Daga, Emilio Ciusani, Massimo Serra, Lino Colombo, Sergio Schinelli

Pages: 2683-2694 Published online on: 03 October 2018

Curcolonol suppresses the motility of breast cancer cells by inhibiting LIM kinase 1 to downregulate cofilin 1 phosphorylation

Hong Lu, Jie Chen, Yongming Luo, Huanjun Xu, Ling Xiong, Jianjiang Fu

Pages: 2695-2704 Published online on: 10 October 2018

Regulation of RAB22A by mir-193b inhibits breast cancer growth and metastasis mediated by exosomes

Liang Sun, Miao He, Ning Xu, Da-Hai Xu, Yaacov Ben-David, Zhao-Ying Yang, You-Jun Li

Pages: 2705-2714 Published online on: 25 September 2018

MicroRNA-511 inhibits malignant behaviors of breast cancer by directly targeting SOX9 and regulating the PI3K/Akt pathway

Yuying Zhao, Weifeng Pang, Ning Yang, Ling Hao, Lei Wang

Pages: 2715-2726 Published online on: 27 September 2018

Baicalin inhibits breast cancer development via inhibiting IĸB kinase activation in vitro and in vivo

Yang Gao, Hui Liu, Hongzhi Wang, Hailong Hu, Hongjuan He, Ning Gu, Xiao Han, Qian Guo, Dong Liu, Shuang Cui, Hongjiang Shao, Chengjun Jin, Qiong Wu

Pages: 2727-2736 Published online on: 12 October 2018

Direct comparison of 2‑amino[3‑11C]isobutyric acid and 2‑amino[11C]methyl‑isobutyric acid uptake in eight lung cancer xenograft models

Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Maki Okada, Koichi Kato, Ming‑Rong Zhang, Tsuneo Saga, Tatsuya Higashi

Pages: 2737-2744 Published online on: 16 October 2018

Patterns of copy number alterations in primary breast tumors of South African patients and their impact on functional cellular pathways

Kamil Lupicki, Selene Elifio-Esposito, Aline S. Fonseca, Saulo H. Weber, Bruna Sugita, Bridget C. Langa, Silma R.F. Pereira, Dhirendra Govender, Eugene Panieri, Donavon C. Hiss, Sahar Abdul-Rasool, Luciane R. Cavalli

Pages: 2745-2757 Published online on: 10 October 2018

Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cells

Jun-Yan Cai, Tong-Tong Xu, Ye Wang, Jing-Jian Chang, Jian Li, Xiao-Yang Chen, Xi Chen, Yi-Fei Yin, Xue-Jun Ni

Pages: 2758-2768 Published online on: 18 September 2018

miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1

Haijin Huang, Jie Tang, Lei Zhang, Yanzhi Bu, Xiaoyu Zhang

Pages: 2769-2779 Published online on: 11 October 2018

HLTF suppresses the migration and invasion of colorectal cancer cells via TGF‑β/SMAD signaling in vitro

Li Liu, Huan Liu, Yangying Zhou, Jiaofeng He, Qiong Liu, Jian Wang, Manting Zeng, Dan Yuan, Fengbo Tan, Yuan Zhou, Haiping Pei, Hong Zhu

Pages: 2780-2788 Published online on: 10 October 2018

Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK-mediated DR5 regulation in colorectal cancer

Se-Lim Kim, In Suk Min, Young Ran Park, Soo Teik Lee, Sang-Wook Kim

Pages: 2789-2799 Published online on: 14 September 2018
Open Access

[Corrigendum] Phospho‑valproic acid inhibits pancreatic cancer growth in mice: Enhanced efficacy by its formulation in poly‑(L)‑lactic acid‑poly(ethylene glycol) nanoparticles

George Mattheolabakis, Ruixue Wang, Basil Rigas, Gerardo G. Mackenzie

Pages: 2800-2800 Published online on: 05 October 2018
Journal Cover

Cover Legend PDF

December 2018
Volume 53 Issue 6

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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