Journal Articles

Open Access

Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells

Athanasios Bikas, Kirk Jensen, Aneeta Patel, John Costello, Gregory Kaltsas, Victoria Hoperia, Leonard Wartofsky, Kenneth Burman, Vasyl Vasko

Pages: 7-20 Published online on: 16 May 2019
Open Access

Downregulated LRRK2 gene expression inhibits proliferation and migration while promoting the apoptosis of thyroid cancer cells by inhibiting activation of the JNK signaling pathway

Zheng‑Cai Jiang, Xiao‑Jun Chen, Qi Zhou, Xiao‑Hua Gong, Xiong Chen, Wen‑Jun Wu

Pages: 21-34 Published online on: 29 May 2019
Open Access

S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelial‑mesenchymal transition and activating the Wnt/β‑catenin pathway

He Zha, Xueru Li, Hui Sun, Liang Duan, Shimei Yuan, Huan Li, Aifang Li, Yue Gu, Jiali Zhao, Jiaqing Xie, Lan Zhou

Pages: 35-44 Published online on: 02 May 2019
Open Access

Targeting miR‑155‑5p and miR‑221‑3p by peptide nucleic acids induces caspase‑3 activation and apoptosis in temozolomide‑resistant T98G glioma cells

Roberta Milani, Eleonora Brognara, Enrica Fabbri, Alex Manicardi, Roberto Corradini, Alessia Finotti, Jessica Gasparello, Monica Borgatti, Lucia Carmela Cosenza, Ilaria Lampronti, Maria Cristina Dechecchi, Giulio Cabrini, Roberto Gambari

Pages: 59-68 Published online on: 23 May 2019
Open Access

Extracellular RNAs from lung cancer cells activate epithelial cells and induce neutrophil extracellular traps

Yan Li, Yonglin Yang, Tingting Gan, Jiawei Zhou, Fan Hu, Nannan Hao, Baorui Yuan, Yu Chen, Mingshun Zhang

Pages: 69-80 Published online on: 21 May 2019
Open Access

PLEKHO1 knockdown inhibits RCC cell viability in vitro and in vivo, potentially by the Hippo and MAPK/JNK pathways

Zi Yu, Qiang Li, Gejun Zhang, Chengcheng Lv, Qingzhuo Dong, Cheng Fu, Chuize Kong, Yu Zeng

Pages: 81-92 Published online on: 30 May 2019
Open Access

lncRNA SNHG16 is associated with proliferation and poor prognosis of pediatric neuroblastoma

Yongbo Yu, Feng Chen, Yeran Yang, Yaqiong Jin, Jin Shi, Shujing Han, Ping Chu, Jie Lu, Jun Tai, Shengcai Wang, Wei Yang, Huanmin Wang, Yongli Guo, Xin Ni

Pages: 93-102 Published online on: 24 May 2019
Open Access

Overexpression of Sirt6 promotes M2 macrophage transformation, alleviating renal injury in diabetic nephropathy

Liqiang Ji, Yifang Chen, Hongqiang Wang, Wei Zhang, Lanxiang He, Jingmin Wu, Yinghui Liu

Pages: 103-115 Published online on: 14 May 2019
Open Access

Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells

Aparna Maiti, Qianya Qi, Xuan Peng, Li Yan, Kazuaki Takabe, Nitai C. Hait

Pages: 116-130 Published online on: 06 May 2019
Open Access

Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2

Ying Zhou, Wei Wang, Rui Wei, Guiying Jiang, Fei Li, Xi Chen, Xueqian Wang, Sixiang Long, Ding Ma, Ling Xi

Pages: 131-141 Published online on: 02 May 2019
Open Access

MicroRNA hsa-miR-623 directly suppresses MMP1 and attenuates IL-8-induced metastasis in pancreatic cancer

Yutong Chen, Siqi Peng, Hong Cen, Yujing Lin, Chumei Huang, Yinting Chen, Hong Shan, Yonghui Su, Linjuan Zeng

Pages: 142-156 Published online on: 17 May 2019

Activated androgen receptor accelerates angiogenesis in cutaneous neurofibroma by regulating VEGFA transcription

Jing Jia, Haibao Zhang, Hongke Zhang, Huicong Du, Wenbo Liu, Maoguo Shu

Pages: 157-166 Published online on: 06 May 2019

Epigenetic modulators hydralazine and sodium valproate act synergistically in VEGI-mediated anti-angiogenesis and VEGF interference in human osteosarcoma and vascular endothelial cells

Shunsuke Kumanishi, Koji Yamanegi, Hiroshi Nishiura, Yuki Fujihara, Kenta Kobayashi, Keiji Nakasho, Hiroyuki Futani, Shinichi Yoshiya

Pages: 167-178 Published online on: 23 May 2019

Epithelial ovarian cancer stem‑like cells are resistant to the cellular lysis of cytokine‑induced killer cells via HIF1A‑mediated downregulation of ICAM‑1

Shixia Bu, Boning Li, Qian Wang, Tingting Gu, Qianggang Dong, Xiaofei Miao, Dongmei Lai

Pages: 179-190 Published online on: 03 May 2019

The XIAP inhibitor embelin sensitises malignant rhabdoid tumour cells to TRAIL treatment via enhanced activation of the extrinsic apoptotic pathway

Rachel Coyle, Karen Slattery, Leanne Ennis, Maureen J. O'sullivan, Daniela M. Zisterer

Pages: 191-202 Published online on: 20 May 2019

Inhibition of JAK2/STAT3 and activation of caspase‑9/3 are involved in KYS05090S‑induced apoptosis in ovarian cancer cells

Bo‑Im Kim, Ju‑Ha Kim, Deok Yong Sim, Minho Nam, Ji Hoon Jung, Bumsang Shim, Jaeyeol Lee, Sung‑Hoon Kim

Pages: 203-210 Published online on: 03 May 2019

S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer

Hiromichi Nakayama, Kenoki Ohuchida, Akiko Yonenaga, Akiko Sagara, Yohei Ando, Shin Kibe, Shin Takesue, Toshiya Abe, Sho Endo, Kazuhiro Koikawa, Takashi Okumura, Koji Shido, Kei Miyoshi, Kohei Nakata, Taiki Moriyama, Yoshihiro Miyasaka, Shigetaka Inoue, Takao Ohtsuka, Kazuhiro Mizumoto, Masafumi Nakamura

Pages: 211-222 Published online on: 24 May 2019

Effects of 5-FU and anti-EGFR antibody in combination with ASA on the spherical culture system of HCT116 and HT29 colorectal cancer cell lines

Agata Olejniczak-Kęder, Magdalena Szaryńska, Agata Wrońska, Kamila Siedlecka-Kroplewska, Zbigniew Kmieć

Pages: 223-242 Published online on: 23 May 2019

Establishment and characterization of a novel cell line (cc‑006cpm8) of moderately/poorly differentiated colorectal adenocarcinoma derived from a primary tumor of a patient

Xia Chu, Yiqi Xue, Xinying Huo, Jingsun Wei, Yuetong Chen, Rongbo Han, Hong Chen, Xinyu Su, Honghong Zhang, Yang Gong, Jinfei Chen

Pages: 243-256 Published online on: 21 May 2019

CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1

Lina Shan, Minjie Zhao, Ya Lu, Hongjuan Ning, Shuman Yang, Yonggui Song, Wenshu Chai, Xianbao Shi

Pages: 257-266 Published online on: 20 May 2019

Transforming growth factor‑β/miR‑143‑3p/cystatin B axis is a therapeutic target in human ovarian cancer

Wencai Guan, Xingxing Wang, Qunbo Lin, Jinguo Zhang, Weimin Ren, Guoxiong Xu

Pages: 267-276 Published online on: 28 May 2019

USP39 promotes ovarian cancer malignant phenotypes and carboplatin chemoresistance

Lingzhi Wang, Tanxiu Chen, Xukun Li, Wei Yan, Yanhui Lou, Zhihua Liu, Hongyan Chen, Zhumei Cui

Pages: 277-288 Published online on: 29 May 2019

PF‑114, a novel selective inhibitor of BCR‑ABL tyrosine kinase, is a potent inducer of apoptosis in chronic myelogenous leukemia cells

Ekaterina S. Ivanova, Victor V. Tatarskiy, Margarita A. Yastrebova, Alvina I. Khamidullina, Alexei V. Shunaev, Anastasia A. Kalinina, Alexei A. Zeifman, Fedor N. Novikov, Yulia V. Dutikova, Ghermes G. Chilov, Alexander A. Shtil

Pages: 289-297 Published online on: 14 May 2019

Leptin stimulates the epithelial‑mesenchymal transition and pro‑angiogenic capability of cholangiocarcinoma cells through the miR‑122/PKM2 axis

Chuang Peng, Zengpeng Sun, Ou Li, Chao Guo, Weimin Yi, Zhaoxia Tan, Bo Jiang

Pages: 298-308 Published online on: 21 May 2019

Potent and specific fusion toxins consisting of a HER2‑binding, ABD‑derived affinity protein, fused to truncated versions of Pseudomonas exotoxin A

Hao Liu, Sarah Lindbo, Haozhong Ding, Mohamed Altai, Javad Garousi, Anna Orlova, Vladimir Tolmachev, Sophia Hober, Torbjörn Gräslund

Pages: 309-319 Published online on: 28 May 2019

Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non‑small cell lung cancer cells

Tae‑Rin Min, Hyun‑Ji Park, Ki‑Tae Ha, Gyoo‑Yong Chi, Yung‑Hyun Choi, Shin‑Hyung Park

Pages: 320-330 Published online on: 07 May 2019

Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo

Jianwen Ye, Lei Qi, Kunlun Chen, Renfeng Li, Shengping Song, Chuang Zhou, Wenlong Zhai

Pages: 331-339 Published online on: 31 May 2019
Open Access

[Corrigendum] Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer

Yu-Hua Xu, Jian-Ren Tu, Tian-Tian Zhao, Shi-Guang Xie, Sheng-Bo Tang

Pages: 340-340 Published online on: 14 January 2019
Journal Cover

Cover Legend PDF

July 2019
Volume 55 Issue 1

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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