Journal Articles

Open Access

CRISPR therapeutic tools for complex genetic disorders and cancer (Review)

Stella Baliou, Maria Adamaki, Anthony M. Kyriakopoulos, Demetrios A. Spandidos, Mihalis Panayiotidis, Ioannis Christodoulou, Vassilis Zoumpourlis

Pages: 443-468 Published online on: 06 June 2018

Cancer stem cells and hypoxia-inducible factors (Review)

Wei-Wei Tong, Guang-Hui Tong, Yong Liu

Pages: 469-476 Published online on: 22 May 2018

Implications of nestin in breast cancer pathogenesis (Review)

Aleksandra Nowak, Piotr Dziegiel

Pages: 477-487 Published online on: 14 June 2018
Open Access

Involvement of TIMP-1 in PECAM-1-mediated tumor dissemination

Valsamma Abraham, Gaoyuan Cao, Andrew Parambath, Fareedah Lawal, Chakkrapong Handumrongkul, Robert Debs, Horace M. DeLisser

Pages: 488-502 Published online on: 25 May 2018
Open Access

Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL

Tomohisa Ito, Takashi Ando, Miki Suzuki-Karasaki, Tomohiko Tokunaga, Yukihiro Yoshida, Toyoko Ochiai, Yasuaki Tokuhashi, Yoshihiro Suzuki-Karasaki

Pages: 503-514 Published online on: 21 May 2018
Open Access

Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells

Lianhua Zhang, Guoliang Yang, Ruiyun Zhang, Liang Dong, Haige Chen, Juanjie Bo, Wei Xue , Yiran Huang

Pages: 515-526 Published online on: 30 May 2018
Open Access

Exosome-mediated transfer of lncRNA RP11‑838N2.4 promotes erlotinib resistance in non-small cell lung cancer

Wei Zhang, Xinrui Cai, Jie Yu, Xuxiang Lu, Qiuhai Qian, Weibin Qian

Pages: 527-538 Published online on: 17 May 2018
Open Access

Microwave hyperthermia promotes caspase‑3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non‑small cell lung cancer cells

Yan-Yan Zhao, Qiong Wu, Zhi-Bing Wu, Jing-Jing Zhang, Lu-Cheng Zhu, Yang Yang, Sheng-Lin Ma, Shi-Rong Zhang

Pages: 539-550 Published online on: 13 June 2018
Open Access

lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma

Xiao Li, Qi Zhao, Jianni Qi, Wenwen Wang, Di Zhang, Zhen Li, Chengyong Qin

Pages: 551-566 Published online on: 23 May 2018
Open Access

E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells

Jiaoe Chen, Chaoju Gong, Huiqin Mao, Zhaoyun Li, Zejun Fang, Qiang Chen, Min Lin, Xiang Jiang, Yanyan Hu, Wei Wang, Xiaomin Zhang, Xianjun Chen, Hongzhang Li

Pages: 567-578 Published online on: 05 June 2018
Open Access

Early synergistic interactions between the HPV16‑E7 oncoprotein and 17β-oestradiol for repressing the expression of Granzyme B in a cervical cancer model

J. Antonio Munguía-Moreno, José Díaz‑Chavéz, Enrique García-Villa, M. Estela Albino-Sanchez, Daniel Mendoza-Villanueva, Rodolfo Ocadiz-Delgado, José Bonilla-Delgado, Armando Marín‑Flores, Enoc M. Cortés-Malagón, Elizabeth Alvarez-Rios, Alfredo Hidalgo-Miranda, Aykut Üren, Haydar Çelik, Paul F. Lambert, Patricio Gariglio

Pages: 579-591 Published online on: 06 June 2018
Open Access

Interaction of S100A1 with LATS1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma

Qingping Guo, Jiale Wang, Zeyu Cao, Yongchang Tang, Chao Feng, Feizhou Huang

Pages: 592-602 Published online on: 05 June 2018
Open Access

Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer

Peng Lin, Yun He, Dong-Yue Wen, Xiao-Jiao Li, Jing-Jing Zeng, Wei-Jia Mo, Qing Li, Jin-Bo Peng, Yu-Quan Wu, Deng-Hua Pan, Hai-Yuan Li, Qiu-Yan Mo, Yun-Peng Wei, Hong Yang, Gang Chen

Pages: 603-619 Published online on: 11 May 2018
Open Access

TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancer

Yue Zhang, Yifei Feng, Dongjian Ji, Qingyuan Wang, Wenwei Qian, Shijia Wang, Zhiyuan Zhang, Bing Ji, Chuan Zhang, Yueming Sun, Zan Fu

Pages: 620-632 Published online on: 16 May 2018
Open Access

A novel scoring system for gastric cancer risk assessment based on the expression of three CLIP4 DNA methylation-associated genes

Chenggong Hu, Yongfang Zhou, Chang Liu, Yan Kang

Pages: 633-643 Published online on: 06 June 2018
Open Access

MicroRNA-125a-5p enhances the sensitivity of esophageal squamous cell carcinoma cells to cisplatin by suppressing the activation of the STAT3 signaling pathway

Yan Zhao, Ke Ma, Shujun Yang, Xiaosan Zhang, Feng Wang, Xiaqing Zhang, Hongtao Liu, Qingxia Fan

Pages: 644-658 Published online on: 16 May 2018
Open Access

High mobility group box 1 promotes the epithelial-to-mesenchymal transition in prostate cancer PC3 cells via the RAGE/NF-κB signaling pathway

Jingliang Zhang, Shuai Shao, Donghui Han, Yuerong Xu, Dian Jiao, Jieheng Wu, Fa Yang, Yufeng Ge, Shengjia Shi, Yu Li, Weihong Wen, Weijun Qin

Pages: 659-671 Published online on: 23 May 2018
Open Access

WAVE3 promotes proliferation, migration and invasion via the AKT pathway in pancreatic cancer

Shaobin Huang, Chensong Huang, Wei Chen, Yifeng Liu, Xiaoyu Yin, Jiaming Lai, Lijian Liang, Qian Wang, Anxun Wang, Chaoxu Zheng

Pages: 672-684 Published online on: 25 May 2018
Open Access

NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer

Ting‑Ting Zhang, Ning Qu, Guo‑Hua Sun, Long Zhang, Yuan‑Jin Wang, Xiang‑Ming Mu, Wen‑Jun Wei, Yu‑Long Wang, Yu Wang, Qing‑Hai Ji, Yong‑Xue Zhu, Rong‑Liang Shi

Pages: 685-693 Published online on: 31 May 2018

Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer

Mi Ae Kang, Wonwoo Kim, Hye-Ram Jo, Young-Joo Shin, Moon-Hong Kim, Jae-Hoon Jeong

Pages: 703-712 Published online on: 31 May 2018

Prognostic value of MAGEA4 in primary lung cancer depends on subcellular localization and p53 status

Aki Fujiwara-Kuroda, Tatsuya Kato, Takehiro Abiko, Takahiro Tsuchikawa, Noriaki Kyogoku, Masaomi Ichinokawa, Kimitaka Tanaka, Takehiro Noji, Yasuhiro Hida, Kichizo Kaga, Yoshiro Matsui, Hiroaki Ikeda, Shinichi Kageyama, Hiroshi Shiku, Satoshi Hirano

Pages: 713-724 Published online on: 31 May 2018

HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer

Satoshi Sugita, Hideki Enokida, Hirofumi Yoshino, Kazutaka Miyamoto, Masaya Yonemori, Takashi Sakaguchi, Yoichi Osako, Masayuki Nakagawa

Pages: 725-736 Published online on: 11 June 2018

Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer

Yoshinaga Okugawa, Yuji Toiyama, Takashi Ichikawa, Mikio Kawamura, Hiromi Yasuda, Hiroyuki Fujikawa, Susumu Saigusa, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Motoyoshi Tanaka, Chikao Miki, Masato Kusunoki

Pages: 737-749 Published online on: 16 May 2018

Baicalein induces the apoptosis of HCT116 human colon cancer cells via the upregulation of DEPP/Gadd45a and activation of MAPKs

Meng-Qi Su, Yi-Ran Zhou, Xuan Rao, Hong Yang, Xin‑Hao Zhuang, Xue-Jia Ke, Guang-Yong Peng, Chang-Lin Zhou, Bai-Yong Shen, Jie Dou

Pages: 750-760 Published online on: 11 May 2018

Andrographolide induces degradation of mutant p53 via activation of Hsp70

Hirofumi Sato, Masatsugu Hiraki, Takushi Namba, Noriyuki Egawa, Koichi Baba, Tomokazu Tanaka, Hirokazu Noshiro

Pages: 761-770 Published online on: 22 May 2018

miRNA expression profiling regulates necroptotic cell death in hepatocellular carcinoma

Maria Visalli, Marcello Bartolotta, Francesca Polito, Rosaria Oteri, Adalberto Barbera, Roberto Arrigo, Rosa Maria Di Giorgio, Giuseppe Navarra, M'hammed Aguennouz

Pages: 771-780 Published online on: 17 May 2018

Let‑7d inhibits colorectal cancer cell proliferation through the CST1/p65 pathway

Jie Jiang, Hui-Ling Liu, Li Tao, Xian-Yi Lin, Yi-Dong Yang, Si-Wei Tan, Bin Wu

Pages: 781-790 Published online on: 23 May 2018

Matrine exerts inhibitory effects in melanoma through the regulation of miR-19b-3p/PTEN

Yan Ping Wei, Xiang Hua Wang, Gang Liu, Jin Feng Zhang, Yong Xian Yang, Juan Zhang, Xiao Li Song, Zhong Dong Li, Lin Dong Zhao

Pages: 791-800 Published online on: 21 May 2018

Mitotic kinase PBK/TOPK as a therapeutic target for adult T‑cell leukemia/lymphoma

Chie Ishikawa, Masachika Senba, Naoki Mori

Pages: 801-814 Published online on: 01 June 2018

Nicotine inhibits CD24 expression in Lewis lung carcinoma cells by upregulation of RAS expression

Da-Hua Liu, Min An, Bai-Li Bao, Fu Ren, Pu Xia

Pages: 815-822 Published online on: 22 May 2018

Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2

Yongsheng Xie, Bo Li, Wenxuan Bu, Lu Gao, Yong Zhang, Xiucai Lan, Jun Hou, Zhijian Xu, Shuaikang Chang, Dandan Yu, Bingqian Xie, Yingcong Wang, Houcai Wang, Yiwen Zhang, Xiaosong Wu, Weiliang Zhu, Jumei Shi

Pages: 823-834 Published online on: 12 June 2018

Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest

Christine Oak, Ahmad O. Khalifa, Ilaha Isali, Natarajan Bhaskaran, Ethan Walker, Sanjeev Shukla

Pages: 835-843 Published online on: 16 May 2018

The HDAC6 inhibitor ACY‑1215 enhances the anticancer activity of oxaliplatin in colorectal cancer cells

Dong Hoon Lee, Hye-Rim Won, Hyun-Wook Ryu, Jung Min Han, So Hee Kwon

Pages: 844-854 Published online on: 11 May 2018

Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells

Junxiu Liu, Dawei Liu, Jasmine J. Liu, Chang Zhao, Shuzhong Yao, Liang Hong

Pages: 855-865 Published online on: 12 June 2018

A panel of 7 prognosis-related long non-coding RNAs to improve platinum-based chemoresistance prediction in ovarian cancer

Jing Song, Wanfeng Zhang, Sen Wang, Kun Liu, Fangzhou Song, Longke Ran

Pages: 866-876 Published online on: 11 May 2018

Salidroside inhibits migration, invasion and angiogenesis of MDA‑MB 231 TNBC cells by regulating EGFR/Jak2/STAT3 signaling via MMP2

Dong Young Kang, Nipin Sp, Doh Hoon Kim, Youn Hee Joung, Hyo Gun Lee, Young Min Park, Young Mok Yang

Pages: 877-885 Published online on: 05 June 2018

Knockdown of GA-binding protein subunit β1 inhibits cell proliferation via p21 induction in renal cell carcinoma

Szu-Chia Chen, Meng-Chi Yen, Feng-Wei Chen, Ling-Yu Wu, Shiang-Jie Yang, Po-Lin Kuo, Ya-Ling Hsu

Pages: 886-894 Published online on: 17 May 2018

Deubiquitinase USP48 promotes ATRA-induced granulocytic differentiation of acute promyelocytic leukemia cells

Lianlian Li, Yong Wang, Xiaoyu Zhang, Guanhua Song, Qiang Guo, Zhiyong Zhang, Yutao Diao, Haipeng Yin, Hongyan Liu, Guosheng Jiang

Pages: 895-903 Published online on: 13 June 2018

Wnt inhibitory factor-1-mediated autophagy inhibits Wnt/β-catenin signaling by downregulating dishevelled-2 expression in non-small cell lung cancer cells

Xinmei Luo, Sujuan Ye, Qianqian Jiang, Yi Gong, Yue Yuan, Xueting Hu, Xiaolan Su, Wen Zhu

Pages: 904-914 Published online on: 15 June 2018
Open Access

[Corrigendum] Long non‑coding RNA H19 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma

Yonglong Hong, Haitao He, Wen Sui, Jingge Zhang, Shenfu Zhang, Dajiang Yang

Pages: 915-915 Published online on: 01 June 2018
Journal Cover

Cover Legend PDF

August 2018
Volume 53 Issue 2

Print ISSN: 1019-6439
Online ISSN: 1791-2423

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