Open Access

Outcomes of organ preservation treatment in advanced laryngeal carcinoma: A retrospective analysis from a single institution

  • Authors:
    • Afsar Fasaludeen
    • Rejnish Ravi Kumar
    • Malu Rafi
    • Farida Nazeer
    • Aparna Mullangath Prakasan
    • Naveen Kumar
    • Preethi George
    • Kunnambath Ramadas
    • Kainickal Cessal Thommachan
  • View Affiliations

  • Published online on: November 15, 2022     https://doi.org/10.3892/mco.2022.2597
  • Article Number: 1
  • Copyright: © Fasaludeen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chemoradiation is the standard treatment for patients with locally advanced laryngeal carcinoma with intact cartilage and functional larynx. The aim of this retrospective study was to assess overall survival (OS) and disease‑free survival (DFS) of patients with locally advanced (stage III and stage IV) squamous cell carcinoma of the larynx who have been treated with definitive radical radiotherapy (RT) with or without chemotherapy in a tertiary cancer center in India between January 1, 2006 and December 31, 2015. Data were collected using structured proforma. The patients were treated with RT alone, induction chemotherapy (IC) followed by RT, concurrent chemoradiation therapy (CCRT) or IC followed by CCRT. Response assessment was conducted at 3‑4 months post‑treatment. Patient‑, tumor‑ and treatment‑related factors were documented and were associated with DFS and OS. Survival curves were generated using the Kaplan‑Meier method and the statistical significance of survival curves was assessed using the log‑rank test. Prognostic factors were assessed using the Cox proportional hazards regression model. A total of 630 patients were included in the present study. The most common age group at presentation was 50‑70 years (n=477; 75.7%) and 95.4% (n=601) patients were male. The most common stage at presentation was stage III (n=367, 58.1%). The median follow‑up period for the entire group of was 59 months (range, 2‑175 months). A complete response after treatment was seen in 549 patients (87.1%). Salvage surgery was performed for 11 patients with residual disease. A total of 134 patients (21.3%) had developed locoregional and distant relapses, and salvage surgery was performed for 31 out of 102 patients with locoregional relapse. The 5‑year OS was 48.7% and the 5‑year DFS was 45.7%. The stage‑wise OS rates were 58.9, 34.9 and 30.4% (P=0.001) and the stage‑wise DFS rates were 56.3, 32.0 and 21.7 (P=0.001) for stage III, IVa and IVb, respectively. Results from the present study demonstrated the feasibility of delivery of chemoradiation protocols with good results in a developing country.

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Spandidos Publications style
Fasaludeen A, Kumar RR, Rafi M, Nazeer F, Prakasan AM, Kumar N, George P, Ramadas K and Thommachan KC: Outcomes of organ preservation treatment in advanced laryngeal carcinoma: A retrospective analysis from a single institution. Mol Clin Oncol 18: 1, 2023
APA
Fasaludeen, A., Kumar, R.R., Rafi, M., Nazeer, F., Prakasan, A.M., Kumar, N. ... Thommachan, K.C. (2023). Outcomes of organ preservation treatment in advanced laryngeal carcinoma: A retrospective analysis from a single institution. Molecular and Clinical Oncology, 18, 1. https://doi.org/10.3892/mco.2022.2597
MLA
Fasaludeen, A., Kumar, R. R., Rafi, M., Nazeer, F., Prakasan, A. M., Kumar, N., George, P., Ramadas, K., Thommachan, K. C."Outcomes of organ preservation treatment in advanced laryngeal carcinoma: A retrospective analysis from a single institution". Molecular and Clinical Oncology 18.1 (2023): 1.
Chicago
Fasaludeen, A., Kumar, R. R., Rafi, M., Nazeer, F., Prakasan, A. M., Kumar, N., George, P., Ramadas, K., Thommachan, K. C."Outcomes of organ preservation treatment in advanced laryngeal carcinoma: A retrospective analysis from a single institution". Molecular and Clinical Oncology 18, no. 1 (2023): 1. https://doi.org/10.3892/mco.2022.2597