Open Access

Conservative treatment of endometrial cancer in women of reproductive age (Review)

  • Authors:
    • Maria Zoi Bourou
    • Alkis Matsas
    • Thomas Vrekoussis
    • Georgios Mastorakos
    • Georgios Valsamakis
    • Theodoros Panoskaltsis
  • View Affiliations

  • Published online on: May 25, 2023     https://doi.org/10.3892/mco.2023.2651
  • Article Number: 55
  • Copyright: © Bourou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endometrial cancer is the fifth most common female cancer worldwide and the third leading female cancer in the Western world. The marked surge in endometrial cancer incidence is alarming. The aim of the present review is to focus on endometrial cancer affecting young women of reproductive age. Surgery, namely abdominal or laparoscopic hysterectomy, with or without salpingo‑oophorectomy, and sentinel lymph node detection has become the standard surgical strategy for early stage endometrioid endometrial cancer. However, premenopausal women might want to preserve their fertility, especially if they are nulliparous or have not reached their desired number of children at the time of diagnosis. Conservative, uterus‑sparing treatment, based on progestin products, may be an advantageous option for patients meeting the necessary criteria. Potential candidates have to be committed to following a rigorous protocol of treatment, investigations and follow‑up. The evidence in favor of this approach, although limited, is encouraging and patients who have achieved a histologically documented disease complete remission could attempt to conceive spontaneously or with the immediate use of assisted reproductive technology techniques. The risk of partial or negative response to progestin treatment or cancer recurrence is well documented, thus patients have to be aware of the possible need for interruption of conservative treatment and hysterectomy.

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July-2023
Volume 19 Issue 1

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Spandidos Publications style
Bourou M, Matsas A, Vrekoussis T, Mastorakos G, Valsamakis G and Panoskaltsis T: Conservative treatment of endometrial cancer in women of reproductive age (Review). Mol Clin Oncol 19: 55, 2023
APA
Bourou, M., Matsas, A., Vrekoussis, T., Mastorakos, G., Valsamakis, G., & Panoskaltsis, T. (2023). Conservative treatment of endometrial cancer in women of reproductive age (Review). Molecular and Clinical Oncology, 19, 55. https://doi.org/10.3892/mco.2023.2651
MLA
Bourou, M., Matsas, A., Vrekoussis, T., Mastorakos, G., Valsamakis, G., Panoskaltsis, T."Conservative treatment of endometrial cancer in women of reproductive age (Review)". Molecular and Clinical Oncology 19.1 (2023): 55.
Chicago
Bourou, M., Matsas, A., Vrekoussis, T., Mastorakos, G., Valsamakis, G., Panoskaltsis, T."Conservative treatment of endometrial cancer in women of reproductive age (Review)". Molecular and Clinical Oncology 19, no. 1 (2023): 55. https://doi.org/10.3892/mco.2023.2651