Open Access

Types of acute phase reactants and their importance in vaccination (Review)

  • Authors:
    • Rafaat H. Khalil
    • Nabil Al-Humadi
  • View Affiliations

  • Published online on: February 11, 2020     https://doi.org/10.3892/br.2020.1276
  • Pages: 143-152
  • Copyright: © Khalil et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Vaccines are considered to be one of the most cost‑effective life‑saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade‑offs. Trade‑offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Thus, studying acute phase proteins (APPs) during vaccination may aid our understanding of APRs and homeostatic changes which can result from inflammatory responses. Depending on the severity of the response in humans, these reactions can be classified as major, moderate or minor. In this review, types of APPs and their importance in vaccination will be discussed.

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April 2020
Volume 12 Issue 4

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APA
Khalil, R.H., & Khalil, R.H. (2020). Types of acute phase reactants and their importance in vaccination (Review). Biomedical Reports, 12, 143-152. https://doi.org/10.3892/br.2020.1276
MLA
Khalil, R. H., Al-Humadi, N."Types of acute phase reactants and their importance in vaccination (Review)". Biomedical Reports 12.4 (2020): 143-152.
Chicago
Khalil, R. H., Al-Humadi, N."Types of acute phase reactants and their importance in vaccination (Review)". Biomedical Reports 12, no. 4 (2020): 143-152. https://doi.org/10.3892/br.2020.1276