Open Access

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)

  • Authors:
    • Wenwen Tang
    • Yin Zhang
    • Haifang Zhang
    • Kejun Li
    • Zhihua Zhao
    • Huijie Ma
    • Xinli Jiang
    • Zhiyang Jia
    • Qingmin Ma
  • View Affiliations

  • Published online on: June 6, 2024     https://doi.org/10.3892/br.2024.1799
  • Article Number: 111
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Retinopathy of prematurity (ROP) is a retinopathy caused by abnormal proliferation of blood vessels in premature infants. It can lead to retinal detachment and, in severe cases, blindness, rendering ROP a critical condition. Advances in neonatal medicine have improved survival rates of low birth weight and low gestational age infants. However, this progress has also led to a rise in incidence of ROP. Currently, premature birth, low birth weight and high postpartum oxygen levels are independent risk factors for ROP. Other factors include mode of delivery, multiple births, anemia, blood transfusion, maternal pregnancy factors, neonatal bronchopulmonary dysplasia, use of surfactants, arterial ductus arteriosus and necrotizing enterocolitis. Laboratory indicators in premature infants such as platelet count, levels of blood glucose, inflammatory cells, lipid and hemoglobin and blood transfusion may also be associated with ROP. However, the etiology and pathogenesis of ROP are not fully understood. A number of factors may influence the onset and progression of ROP, including decreased platelet counts, decreased hemoglobin levels, increased white blood cell counts, increased blood glucose levels, and disorders of lipid metabolism. The present study reviewed the effects of platelet count, hemoglobin, blood glucose, inflammatory cells and factors, blood lipids, and plasma metabolic pathways on ROP.

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August-2024
Volume 21 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Tang W, Zhang Y, Zhang H, Li K, Zhao Z, Ma H, Jiang X, Jia Z and Ma Q: Progress in the study of association between hematological indicators and retinopathy of prematurity (Review). Biomed Rep 21: 111, 2024
APA
Tang, W., Zhang, Y., Zhang, H., Li, K., Zhao, Z., Ma, H. ... Ma, Q. (2024). Progress in the study of association between hematological indicators and retinopathy of prematurity (Review). Biomedical Reports, 21, 111. https://doi.org/10.3892/br.2024.1799
MLA
Tang, W., Zhang, Y., Zhang, H., Li, K., Zhao, Z., Ma, H., Jiang, X., Jia, Z., Ma, Q."Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)". Biomedical Reports 21.2 (2024): 111.
Chicago
Tang, W., Zhang, Y., Zhang, H., Li, K., Zhao, Z., Ma, H., Jiang, X., Jia, Z., Ma, Q."Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)". Biomedical Reports 21, no. 2 (2024): 111. https://doi.org/10.3892/br.2024.1799