Materials of biological origin and biofuels: Small environmental footprint and epigenetic impact (Review)

Papakonstantinou,Eleni; Mitsis,Thanasis; Dragoumani,Konstantina; Efthimiadou,Aspasia; Bacopoulou,Flora; Chrousos,George P.; Eliopoulos,Elias; Vlachakis,Dimitrios

doi:10.3892/ije.2021.6

Materials of biological origin and biofuels: Small environmental footprint and epigenetic impact (Review)

Authors:
- Eleni Papakonstantinou
- Thanasis Mitsis
- Konstantina Dragoumani
- Aspasia Efthimiadou
- Flora Bacopoulou
- George P. Chrousos
- Elias Eliopoulos
- Dimitrios Vlachakis
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Affiliations: Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece, Department of Soil Science of Athens, Institute of Soil and Water Resources, Hellenic Agricultural Organization‑Demeter, 14123 Lycovrisi, Greece, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children's Hospital, 11527 Athens, Greece
Published online on: August 11, 2021 https://doi.org/10.3892/ije.2021.6
Article Number: 6
Copyright: © Papakonstantinou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Human activity, specifically the overreliance on fossil resources, has had numerous adverse effects on the environment and an epigenetic impact on human health. The destabilization of the environment and the accumulation of waste have caused alterations in the stability of the human ecosystem, affecting the exposome and modifying the epigenetic mechanisms that control or deregulate human physiology. For example, the increasing use of plastics and the chemicals derived, have been shown to promote diseases by altering epigenetic patterns. Thus, there is a growing need for more environmentally‑ and human‑friendly alternatives, also known as ‘green products and fuels’. Environmental biotechnology aims to produce ‘green’ products and fuels through the use of living cells and cell‑derived molecules. The solutions offered by this scientific discipline may include ‘green’ alternatives to chemical solvents, machine lubricants, plastics, machine fuel and batteries. Each of these alternatives has its own strengths and weaknesses that should be taken into consideration before being heralded as the successors of fossil‑derived products. The present review article summarizes the current scientific knowledge on the epigenetic impact of the current environmental status and the benefit of these alternatives.

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1	Institute of Medicine (US): Roundtable on Environmental Health Sciences, Research, and Medicine. In: Health and the Environment in the Southeastern United States. Frumkin H, Jackson RJ and Coussens CM (eds). Institute of Medicine, Washington, DC, 2002.
2	Chao Q and Feng A: Scientific basis of climate change and its response. Global Energy Interconnection. 1:420–427. 2018.
3	Seymour V: The human-nature relationship and its impact on health: A critical review. Frontiers in Public Health. 4:2016.PubMed/NCBI View Article : Google Scholar
4	Wheeler N and Watts N: Climate change: From science to practice. Curr Environ Health Rep. 5:170–178. 2018.PubMed/NCBI View Article : Google Scholar
5	Hathaway J and Maibach EW: Health implications of climate change: A review of the literature about the perception of the public and health professionals. Curr Environ Health Rep. 5:197–204. 2018.PubMed/NCBI View Article : Google Scholar
6	Verones F, Moran D, Stadler K, Kanemoto K and Wood R: Resource footprints and their ecosystem consequences. Sci Rep. 7(40743)2017.PubMed/NCBI View Article : Google Scholar
7	Vanham D, Leip A, Galli A, Kastner T, Bruckner M, Uwizeye A, van Dijk K, Ercin E, Dalin C, Brandão M, et al: Environmental footprint family to address local to planetary sustainability and deliver on the SDGs. Sci Total Environ. 693(133642)2019.PubMed/NCBI View Article : Google Scholar
8	Greally JM: A user's guide to the ambiguous word ‘epigenetics’. Nat Rev Mol Cell Biol. 19:207–208. 2018.PubMed/NCBI View Article : Google Scholar
9	Allis CD and Jenuwein T: The molecular hallmarks of epigenetic control. Nat Rev Genet. 17:487–500. 2016.PubMed/NCBI View Article : Google Scholar
10	Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X and Leung YK: Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J. 53:289–305. 2012.PubMed/NCBI View Article : Google Scholar
11	Balachandar G, Khanna N and Das D: Biohydrogen production from organic wastes by dark fermentation. Biohydrogen. 103–144. 2013.
12	Perera F: Pollution from fossil-fuel combustion is the leading environmental threat to global pediatric health and equity: Solutions Exist. Int J Environ Res Public Health. 15(16)2017.PubMed/NCBI View Article : Google Scholar
13	Armaroli N and Balzani V: The legacy of fossil fuels. Chem Asian J. 6:768–784. 2011.PubMed/NCBI View Article : Google Scholar
14	Anderson TR, Hawkins E and Jones PD: CO₂, the greenhouse effect and global warming: From the pioneering work of Arrhenius and Callendar to today's Earth System Models. Endeavour. 40:178–187. 2016.PubMed/NCBI View Article : Google Scholar
15	Roundtable NRCCS: The National Academies Collection: Reports funded by National Institutes of Health. In: Carbon Management: Implications for R&D in the Chemical Sciences and Technology: A Workshop Report to the Chemical Sciences Roundtable. National Academies Press, National Academy of Sciences, Washington, DC, 2001.
16	Hopewell J, Dvorak R and Kosior E: Plastics recycling: Challenges and opportunities. Philos Trans R Soc Lond B Biol Sci. 364:2115–2126. 2009.PubMed/NCBI View Article : Google Scholar
17	Thompson RC, Moore CJ, vom Saal FS and Swan SH: Plastics, the environment and human health: current consensus and future trends. Philos Trans R Soc Lond B Biol Sci. 364:2153–2166. 2009.PubMed/NCBI View Article : Google Scholar
18	Klemeš JJ, Fan YV, Tan RR and Jiang P: Minimising the present and future plastic waste, energy and environmental footprints related to COVID-19. Renew Sustain Energy Rev. 127:109883. 2020.PubMed/NCBI View Article : Google Scholar
19	Chianese R, Troisi J, Richards S, Scafuro M, Fasano S, Guida M, Pierantoni R and Meccariello R: Bisphenol A in reproduction: Epigenetic effects. Curr Med Chem. 25:748–770. 2018.PubMed/NCBI View Article : Google Scholar
20	Manikkam M, Tracey R, Guerrero-Bosagna C and Skinner MK: Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PLoS One. 8(e55387)2013.PubMed/NCBI View Article : Google Scholar
21	Demeneix BA: Evidence for prenatal exposure to thyroid disruptors and adverse effects on brain development. Eur Thyroid J. 8:283–292. 2019.PubMed/NCBI View Article : Google Scholar
22	Engdahl E, Svensson K, Lin PD, Alavian-Ghavanini A, Lindh C, Ruegg J and Bornehag CG: DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study. Environ Int. 156(106617)2021.PubMed/NCBI View Article : Google Scholar
23	Cimmino I, Fiory F, Perruolo G, Miele C, Beguinot F, Formisano P and Oriente F: Potential Mechanisms of Bisphenol A (BPA) contributing to human disease. Int J Mol Sci. 21:2020.PubMed/NCBI View Article : Google Scholar
24	Ma Y, Xia W, Wang DQ, Wan YJ, Xu B, Chen X, Li YY and Xu SQ: Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood. Diabetologia. 56:2059–2067. 2013.PubMed/NCBI View Article : Google Scholar
25	Provvisiero DP, Pivonello C, Muscogiuri G, Negri M, de Angelis C, Simeoli C, Pivonello R and Colao A: Influence of bisphenol A on type 2 diabetes mellitus. Int J Environ Res Public Health. 13(989)2016.PubMed/NCBI View Article : Google Scholar
26	Shafei A, Ramzy MM, Hegazy AI, Husseny AK, El-Hadary UG, Taha MM and Mosa AA: The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer. Gene. 647:235–243. 2018.PubMed/NCBI View Article : Google Scholar
27	Doherty LF, Bromer JG, Zhou Y, Aldad TS and Taylor HS: In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer. Horm Cancer. 1:146–155. 2010.PubMed/NCBI View Article : Google Scholar
28	Wehbe Z, Nasser SA, El-Yazbi A, Nasreddine S and Eid AH: Estrogen and bisphenol A in hypertension. Curr Hypertens Rep. 22(23)2020.PubMed/NCBI View Article : Google Scholar
29	Hamza M, Halayem S, Mrad R, Bourgou S, Charfi F and Belhadj A: Epigenetics' implication in autism spectrum disorders: A review. Encephale. 43:374–381. 2017.PubMed/NCBI View Article : Google Scholar : (In French).
30	Gupta V, Sengupta M, Prakash J and Tripathy B: An introduction to biotechnology. In: Basic and Applied Aspects of Biotechnology. Springer, Singapore, 2017.
31	Hesham Ael L, Ralebitso-Senior TK, Zhang Y and Li QX: Environmental biotechnology: Current advances, new knowledge gaps, and emerging issues. Biomed Res Int. 2015(814529)2015.PubMed/NCBI View Article : Google Scholar
32	National Research Council: Committee on Biomolecular Materials and Processes: From Molecules to Materials to Machines. National Academies Press, Washington, DC, 2008.
33	Welton T: Solvents and sustainable chemistry. Proc Math Phys Eng Sci. 471(20150502)2015.PubMed/NCBI View Article : Google Scholar
34	de Marco BA, Rechelo BS, Tótoli EG, Kogawa AC and Salgado HRN: Evolution of green chemistry and its multidimensional impacts: A review. Saudi Pharm J. 27:1–8. 2019.PubMed/NCBI View Article : Google Scholar
35	Blossom SJ and Gilbert KM: Epigenetic underpinnings of developmental immunotoxicity and autoimmune disease. Curr Opin Toxicol. 10:23–30. 2018.PubMed/NCBI View Article : Google Scholar
36	Calvo-Flores FG, Monteagudo-Arrebola MJ, Dobado JA and Isac-García J: Green and Bio-Based Solvents. Topics in current chemistry (Cham). 376(18)2018.PubMed/NCBI View Article : Google Scholar
37	Tobiszewski M: Analytical chemistry with biosolvents. Anal Bioanal Chem. 411:4359–4364. 2019.PubMed/NCBI View Article : Google Scholar
38	Nowak P, Kucharska K and Kamiński M: Ecological and health effects of lubricant oils emitted into the environment. Int J Environ Res Public Health. 16(3002)2019.PubMed/NCBI View Article : Google Scholar
39	IARC monographs on the evaluation of carcinogenic risks to humans. Diesel and gasoline engine exhausts and some nitroarenes. International Agency for Research on Cancer. IARC Monogr Eval Carcinog Risks Hum. 46:1–458. 1989.PubMed/NCBI
40	Wang Y, Zhou Q, Peng S, Ma LQ and Niu X: Toxic effects of crude-oil-contaminated soil in aquatic environment on Carassius auratus and their hepatic antioxidant defense system. J Environ Sci (China). 21:612–617. 2009.PubMed/NCBI View Article : Google Scholar
41	Ahmed NS and Nassar AM: Lubricating oil additives. In: Tribology-Lubricants and Lubrication. Kuo CH (ed). IntechOpen, 2011.
42	Wang B, Zhong Z, Qiu H, Chen D, Li W, Li S and Tu X: Nano serpentine powders as lubricant additive: Tribological behaviors and self-repairing performance on worn surface. Nanomaterials (Basel). 10(922)2020.PubMed/NCBI View Article : Google Scholar
43	Keil KP and Lein PJ: DNA methylation: A mechanism linking environmental chemical exposures to risk of autism spectrum disorders? Environ Epigenet. 2(dvv012)2016.PubMed/NCBI View Article : Google Scholar
44	Shi SC and Lu FI: Biopolymer green lubricant for sustainable manufacturing. Materials (Basel). 9(338)2016.PubMed/NCBI View Article : Google Scholar
45	Esquivel-Gaon M, Nguyen NH, Sgroi MF, Pullini D, Gili F, Mangherini D, Pruna AI, Rosicka P, Sevcu A and Castagnola V: In vitro and environmental toxicity of reduced graphene oxide as an additive in automotive lubricants. Nanoscale. 10:6539–6548. 2018.PubMed/NCBI View Article : Google Scholar
46	The future of plastic. Nat Commun. 9(2157)2018.PubMed/NCBI View Article : Google Scholar
47	Geyer R, Jambeck JR and Law KL: Production, use, and fate of all plastics ever made. Sci Adv. 3(e1700782)2017.PubMed/NCBI View Article : Google Scholar
48	Danso D, Chow J and Streit WR: Plastics: Environmental and biotechnological perspectives on microbial degradation. Appl Environ Microbiol. 85:e01095–19. 2019.PubMed/NCBI View Article : Google Scholar
49	Yang CZ, Yaniger SI, Jordan VC, Klein DJ and Bittner GD: Most plastic products release estrogenic chemicals: A potential health problem that can be solved. Environ Health Perspect. 119:989–996. 2011.PubMed/NCBI View Article : Google Scholar
50	Rattan S and Flaws JA: The epigenetic impacts of endocrine disruptors on female reproduction across generationsdagger. Biol Reprod. 101:635–644. 2019.PubMed/NCBI View Article : Google Scholar
51	Andreeßen C and Steinbüchel A: Recent developments in non-biodegradable biopolymers: Precursors, production processes, and future perspectives. Appl Microbiol Biotechnol. 103:143–157. 2019.PubMed/NCBI View Article : Google Scholar
52	Narancic T, Cerrone F, Beagan N and O'Connor KE: Recent advances in bioplastics: Application and biodegradation. Polymers (Basel). 12(920)2020.PubMed/NCBI View Article : Google Scholar
53	Endres HJ: Bioplastics. Adv Biochem Eng Biotechnol. 166:427–468. 2019.PubMed/NCBI View Article : Google Scholar
54	Prieto A: To be, or not to be biodegradable that is the question for the bio-based plastics. Microb Biotechnol. 9:652–657. 2016.PubMed/NCBI View Article : Google Scholar
55	Ciriminna R and Pagliaro M: Biodegradable and compostable plastics: A critical perspective on the dawn of their global adoption. ChemistryOpen. 9:8–13. 2020.PubMed/NCBI View Article : Google Scholar
56	Gan Z and Zhang H: PMBD: A comprehensive plastics microbial biodegradation database. Database (Oxford). 2019(baz119)2019.PubMed/NCBI View Article : Google Scholar
57	Ru J, Huo Y and Yang Y: Microbial degradation and valorization of plastic wastes. Front Microbiol. 11:2020.PubMed/NCBI View Article : Google Scholar
58	Ganesan R, Manigandan S, Samuel MS, Shanmuganathan R, Brindhadevi K, Lan Chi NT, Duc PA and Pugazhendhi A: A review on prospective production of biofuel from microalgae. Biotechnol Rep (Amst). 27(e00509)2020.PubMed/NCBI View Article : Google Scholar
59	Kim EJ, Kim S, Choi H-G and Han SJ: Co-production of biodiesel and bioethanol using psychrophilic microalga Chlamydomonas sp. KNM0029C isolated from Arctic sea ice. Biotechnol Biofuels. 13(20)2020.PubMed/NCBI View Article : Google Scholar
60	Valdivia M, Galan JL, Laffarga J and Ramos JL: Biofuels 2020: Biorefineries based on lignocellulosic materials. Microb Biotechnol. 9:585–594. 2016.PubMed/NCBI View Article : Google Scholar
61	Li X, Zheng Y, Guan C, Cheung CS and Huang Z: Effect of biodiesel on PAH, OPAH, and NPAH emissions from a direct injection diesel engine. Environ Sci Pollut Res Int. 25:34131–34138. 2018.PubMed/NCBI View Article : Google Scholar
62	Aro EM: From first generation biofuels to advanced solar biofuels. Ambio. 45 (Suppl 1):S24–S31. 2016.PubMed/NCBI View Article : Google Scholar
63	Mohr A and Raman S: Lessons from first generation biofuels and implications for the sustainability appraisal of second generation biofuels. Energy Policy. 63:114–122. 2013.PubMed/NCBI View Article : Google Scholar
64	Tapia Carpio LG and Simone de Souza F: Competition between second-generation ethanol and bioelectricity using the residual biomass of sugarcane: Effects of uncertainty on the production mix. Molecules. 24(369)2019.PubMed/NCBI View Article : Google Scholar
65	Hein L and Leemans R: The impact of first-generation biofuels on the depletion of the global phosphorus reserve. Ambio. 41:341–349. 2012.PubMed/NCBI View Article : Google Scholar
66	Sims RE, Mabee W, Saddler JN and Taylor M: An overview of second generation biofuel technologies. Bioresour Technol. 101:1570–1580. 2010.PubMed/NCBI View Article : Google Scholar
67	Ho DP, Ngo HH and Guo W: A mini review on renewable sources for biofuel. Bioresour Technol. 169:742–749. 2014.PubMed/NCBI View Article : Google Scholar
68	Liu D, Zou C and Xu M: Environmental, ecological, and economic benefits of biofuel production using a constructed wetland: A case study in China. Int J Environ Res Public Health. 16(827)2019.PubMed/NCBI View Article : Google Scholar
69	Ramos JL, Valdivia M, García-Lorente F and Segura A: Benefits and perspectives on the use of biofuels. Microb Biotechnol. 9:436–440. 2016.PubMed/NCBI View Article : Google Scholar
70	Balan V: Current challenges in commercially producing biofuels from lignocellulosic biomass. ISRN Biotechnol. 2014(463074)2014.PubMed/NCBI View Article : Google Scholar
71	Neto JM, Komesu A, Da Silva Martins LH, Gonçalves VO, De Oliveira JA and Rai M: Third-generation biofuels: An overview. In: Sustainable Biofuel and Biomass. Apple Academic Press, 2019.
72	Bleakley S and Hayes M: Algal proteins: Extraction, application, and challenges concerning production. Foods. 6(33)2017.PubMed/NCBI View Article : Google Scholar
73	Khoo CG, Dasan YK, Lam MK and Lee KT: Algae biorefinery: Review on a broad spectrum of downstream processes and products. Bioresour Technol. 292(121964)2019.PubMed/NCBI View Article : Google Scholar
74	Behera S, Singh R, Arora R, Sharma NK, Shukla M and Kumar S: Scope of algae as third generation biofuels. Front Bioeng Biotechnol. 2(90)2015.PubMed/NCBI View Article : Google Scholar
75	Shurin JB, Burkart MD, Mayfield SP and Smith VH: Recent progress and future challenges in algal biofuel production. F1000Res. 5(F1000)2016.PubMed/NCBI View Article : Google Scholar
76	Hannon M, Gimpel J, Tran M, Rasala B and Mayfield S: Biofuels from algae: Challenges and potential. Biofuels. 1:763–784. 2010.PubMed/NCBI View Article : Google Scholar
77	Lü J, Sheahan C and Fu P: Metabolic engineering of algae for fourth generation biofuels production. Energy Environ Sci. 4:2451–2466. 2011.
78	Bhardwaj S, Kumar S and Arora R: Bioprospecting of microorganisms for biofuel production. In: Biofuels Production-Sustainability and Advances in Microbial Bioresources. Biofuel and Biorefinery Technologies. Vol 11. Yadav A, Rastegari A, Yadav N and Gaur R (eds). Springer, New York, NY, 2020.
79	Moravvej Z, Makarem MA and Rahimpour MR: Chapter 20-The fourth generation of biofuel. In: Second and Third Generation of Feedstocks. Basile A and Dalena F (eds). Elsevier, Amsterdam, pp557-597, 2019.
80	Xará SM, Delgado JN, Almeida MF and Costa CA: Laboratory study on the leaching potential of spent alkaline batteries. Waste Manag. 29:2121–2131. 2009.PubMed/NCBI View Article : Google Scholar
81	Kang DH, Chen M and Ogunseitan OA: Potential environmental and human health impacts of rechargeable lithium batteries in electronic waste. Environ Sci Technol. 47:5495–5503. 2013.PubMed/NCBI View Article : Google Scholar
82	Martinez-Zamudio R and Ha HC: Environmental epigenetics in metal exposure. Epigenetics. 6:820–827. 2011.PubMed/NCBI View Article : Google Scholar
83	Cheng K, Zhang F, Sun F, Chen H and Percival Zhang YH: Doubling power output of starch biobattery treated by the most thermostable isoamylase from an Archaeon Sulfolobus tokodaii. Sci Rep. 5(13184)2015.PubMed/NCBI View Article : Google Scholar
84	Zhu Z, Kin Tam T, Sun F, You C and Percival Zhang YH: A high-energy-density sugar biobattery based on a synthetic enzymatic pathway. Nat Commun. 5(3026)2014.PubMed/NCBI View Article : Google Scholar
85	Schmidt CW: Biodiesel: Cultivating alternative fuels. Environ Health Perspect. 115:A86–A91. 2007.PubMed/NCBI View Article : Google Scholar
86	Aziz NAM, Yunus R, Hamid HA, Ghassan AAK, Omar R, Rashid U and Abbas Z: An acceleration of microwave-assisted transesterification of palm oil-based methyl ester into trimethylolpropane ester. Sci Rep. 10(19652)2020.PubMed/NCBI View Article : Google Scholar
87	Gao Y, Mohammadifar M and Choi S: From microbial fuel cells to biobatteries: Moving toward on-demand micropower generation for small-scale single-use applications. Adv Materials Technol. 4(1900079)2019.
88	Di Bartolo A, Infurna G and Dintcheva NT: A review of bioplastics and their adoption in the circular economy. Polymers (Basel). 13(1229)2021.PubMed/NCBI View Article : Google Scholar
89	Dong X, Al-Jumaily A and Escobar IC: Investigation of the use of a bio-derived solvent for non-solvent-induced phase separation (NIPS) fabrication of polysulfone membranes. Membranes (Basel). 8(23)2018.PubMed/NCBI View Article : Google Scholar