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Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN®) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer

  • Authors:
    • Tomoya Abe
    • Atsunobu Sagara
    • Daichi Okada
    • Kazumasa Matsuzaka
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Saitama Cancer Center, Ina‑machi, Saitama 362‑0806, Japan, Division of Pharmacy Professional Development and Research, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142‑8501, Japan
    Copyright: © Abe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 41
    |
    Published online on: March 24, 2023
       https://doi.org/10.3892/mco.2023.2637
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Abstract

The present study is a safety survey of patients with human epidermal growth factor receptor type 2‑positive, chemotherapy‑naive breast cancer treated with trastuzumab plus paclitaxel at the Saitama Cancer Center (Saitama, Japan) between April 2018 and March 2022. The expression of infusion reaction (IR) and the effect on cardiac function were investigated in patients who switched from reference trastuzumab (HERCEPTIN®) to biosimilar trastuzumab (Trastuzumab‑NK) and continued treatment (switching group). The two groups (reference vs. biosimilar trastuzumab) had no significant difference in the expression of IR (P>0.999). In the switching group, IR associated with switching did not occur in all nine eligible patients. Left ventricular ejection fraction (LVEF) was used to assess cardiac function, and no patient in either group experienced a significant decrease in LVEF with treatment, meaning that there was no effect of switching on the decrease in LVEF. These results suggested that switching from reference to biosimilar trastuzumab may not have a significant effect on the frequency of IR expression or the occurrence of cardiac dysfunction.
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Copy and paste a formatted citation
Spandidos Publications style
Abe T, Sagara A, Okada D and Matsuzaka K: Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer. Mol Clin Oncol 18: 41, 2023.
APA
Abe, T., Sagara, A., Okada, D., & Matsuzaka, K. (2023). Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer. Molecular and Clinical Oncology, 18, 41. https://doi.org/10.3892/mco.2023.2637
MLA
Abe, T., Sagara, A., Okada, D., Matsuzaka, K."Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer". Molecular and Clinical Oncology 18.5 (2023): 41.
Chicago
Abe, T., Sagara, A., Okada, D., Matsuzaka, K."Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer". Molecular and Clinical Oncology 18, no. 5 (2023): 41. https://doi.org/10.3892/mco.2023.2637
Copy and paste a formatted citation
x
Spandidos Publications style
Abe T, Sagara A, Okada D and Matsuzaka K: Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer. Mol Clin Oncol 18: 41, 2023.
APA
Abe, T., Sagara, A., Okada, D., & Matsuzaka, K. (2023). Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer. Molecular and Clinical Oncology, 18, 41. https://doi.org/10.3892/mco.2023.2637
MLA
Abe, T., Sagara, A., Okada, D., Matsuzaka, K."Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer". Molecular and Clinical Oncology 18.5 (2023): 41.
Chicago
Abe, T., Sagara, A., Okada, D., Matsuzaka, K."Safety survey on infusion reaction and cardiac dysfunction when switching from reference trastuzumab (HERCEPTIN<sup>®</sup>) to biosimilar trastuzumab (Trastuzumab‑NK) in the treatment of HER2‑positive breast cancer". Molecular and Clinical Oncology 18, no. 5 (2023): 41. https://doi.org/10.3892/mco.2023.2637
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