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C‑reactive protein and related predictors in soft tissue sarcoma (Review)

  • Authors:
    • Tomoki Nakamura
    • Kunihiro Asanuma
    • Tomohito Hagi
    • Akihiro Sudo
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan
    Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 6
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    Published online on: November 24, 2023
       https://doi.org/10.3892/mco.2023.2704
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Abstract

C‑reactive protein (CRP) is a useful predictor of poor survival in patients with several types of cancer because inflammation is strongly associated with cancer progression. The production of CRP in hepatocytes appears to be primarily induced at the transcriptional level following the elevation of circulating interleukin‑6 (IL‑6), which is produced by various cell types, including cancer cells and cancer‑associated fibroblasts. Serum CRP levels are associated with serum IL‑6 levels in patients with soft tissue sarcoma (STS). Additionally, patients with elevated CRP levels had worse oncological outcomes than those with normal CRP levels. It has been attempted to combine CRP levels with other inflammatory or immune markers, and the utility of this has been demonstrated. Therefore, a novel treatment strategy should be developed for patients with STS with elevated CRP levels. The present review aimed to clarify the role of CRP levels and related tools in predicting clinical outcomes in patients with STS.
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Copy and paste a formatted citation
Spandidos Publications style
Nakamura T, Asanuma K, Hagi T and Sudo A: C‑reactive protein and related predictors in soft tissue sarcoma (Review). Mol Clin Oncol 20: 6, 2024.
APA
Nakamura, T., Asanuma, K., Hagi, T., & Sudo, A. (2024). C‑reactive protein and related predictors in soft tissue sarcoma (Review). Molecular and Clinical Oncology, 20, 6. https://doi.org/10.3892/mco.2023.2704
MLA
Nakamura, T., Asanuma, K., Hagi, T., Sudo, A."C‑reactive protein and related predictors in soft tissue sarcoma (Review)". Molecular and Clinical Oncology 20.1 (2024): 6.
Chicago
Nakamura, T., Asanuma, K., Hagi, T., Sudo, A."C‑reactive protein and related predictors in soft tissue sarcoma (Review)". Molecular and Clinical Oncology 20, no. 1 (2024): 6. https://doi.org/10.3892/mco.2023.2704
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura T, Asanuma K, Hagi T and Sudo A: C‑reactive protein and related predictors in soft tissue sarcoma (Review). Mol Clin Oncol 20: 6, 2024.
APA
Nakamura, T., Asanuma, K., Hagi, T., & Sudo, A. (2024). C‑reactive protein and related predictors in soft tissue sarcoma (Review). Molecular and Clinical Oncology, 20, 6. https://doi.org/10.3892/mco.2023.2704
MLA
Nakamura, T., Asanuma, K., Hagi, T., Sudo, A."C‑reactive protein and related predictors in soft tissue sarcoma (Review)". Molecular and Clinical Oncology 20.1 (2024): 6.
Chicago
Nakamura, T., Asanuma, K., Hagi, T., Sudo, A."C‑reactive protein and related predictors in soft tissue sarcoma (Review)". Molecular and Clinical Oncology 20, no. 1 (2024): 6. https://doi.org/10.3892/mco.2023.2704
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