Low uric acid level increases the risk of infectious mononucleosis and this effect is more pronounced in women

  • Authors:
    • Li Zhang
    • Pingping Zhou
    • Zhaowei Meng
    • Lu Gong
    • Chongjie Pang
    • Xue Li
    • Qiang Jia
    • Jian Tan
    • Na Liu
    • Tianpeng Hu
    • Qing Zhang
    • Qiyu Jia
    • Kun Song
  • View Affiliations

  • Published online on: October 2, 2017     https://doi.org/10.3892/mco.2017.1433
  • Pages:1039-1044
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Abstract

Infectious mononucleosis (IM) due to Epstein‑Barr virus infection is common. Uric acid (UA) is an important endogenous antioxidant. To the best of our knowledge, the association between UA and IM has not been comprehensively investigated to date. The aim of the present study was to investigate this association in Chinese patients. A total of 95 patients (47 men and 48 women) with IM were recruited, along with 95 healthy controls. Clinical data were classified by patient sex. Receiver operating characteristic (ROC) curve analysis was adopted to determine the cut‑off values of UA for IM diagnosis and prediction. Crude and adjusted odds ratios (ORs) of UA for IM were analyzed by binary logistic regression. The UA levels were significantly lower in IM patients compared with those in controls. In addition, UA levels in men were significantly higher compared with those in women. The ROC curve demonstrated good diagnostic and predictive values of UA for IM in both sexes. The UA cut‑off values were 326.00 and 243.50 µmol/l for diagnosing IM in men and women, respectively, with a diagnostic accuracy of 76.596 and 80.208%, respectively. Binary logistic regression analysis revealed a significant risk of IM in the low UA quartiles in both sexes. Following adjustments, the ORs even increased. Women with low UA levels appeared to be more susceptible to IM. For example, the crude ORs in quartile 1 were 24.000 and 52.500 for men and women, respectively, and the respective adjusted ORs were 31.437 and 301.746 (all P<0.01). To the best of our knowledge, the present study is the first to demonstrate the inverse association between UA and IM, suggesting a progressive decrease of antioxidant reserve in IM. Moreover, low UA was suggestive of IM, particularly in women.

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December 2017
Volume 7 Issue 6

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APA
Zhang, L., Zhou, P., Meng, Z., Gong, L., Pang, C., Li, X. ... Song, K. (2017). Low uric acid level increases the risk of infectious mononucleosis and this effect is more pronounced in women. Molecular and Clinical Oncology, 7, 1039-1044. https://doi.org/10.3892/mco.2017.1433
MLA
Zhang, L., Zhou, P., Meng, Z., Gong, L., Pang, C., Li, X., Jia, Q., Tan, J., Liu, N., Hu, T., Zhang, Q., Jia, Q., Song, K."Low uric acid level increases the risk of infectious mononucleosis and this effect is more pronounced in women". Molecular and Clinical Oncology 7.6 (2017): 1039-1044.
Chicago
Zhang, L., Zhou, P., Meng, Z., Gong, L., Pang, C., Li, X., Jia, Q., Tan, J., Liu, N., Hu, T., Zhang, Q., Jia, Q., Song, K."Low uric acid level increases the risk of infectious mononucleosis and this effect is more pronounced in women". Molecular and Clinical Oncology 7, no. 6 (2017): 1039-1044. https://doi.org/10.3892/mco.2017.1433