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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Epigenetics

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Article

Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice

  • Authors:
    • Runlei Hu
    • Shenglin Ma
    • Xianfu Ke
    • Hong Jiang
    • Dongshan Wei
    • Wei Wang

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Radiation Oncology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China, Laboratory Animal Center, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang 310006, P.R. China
  • Pages: 59-62
    |
    Published online on: November 5, 2015
       https://doi.org/10.3892/br.2015.540
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Abstract

The present study aimed to investigate the therapeutic effect of interleukin‑2 (IL‑2) treatment combined with magnetic fluid hyperthermia (MFH) on Lewis lung cancer‑bearing mice. Magnetic fluids were prepared in vitro and directly injected into the tumors in the mice, which were subjected to an alternating magnetic field. The temperature in the tumor reached 43˚C and was maintained by controlling the strength of magnetic field for 30 min. Twenty‑four hours later, IL‑2 was injected directly into the tumors. Mice were divided into four groups: Group I (control), II (MFH), III (IL‑2) and IV (IL‑2+MFH). The tumor grew gradually in groups II and IV (both P<0.05) compared to the control group. Histological analysis showed that the tumor cells underwent apoptosis and necrosis. Immunohistochemistry results demonstrated that heat‑shock protein 70 and cluster of differentiation (CD) 8‑positive and CD4‑positive T cells were strongly expressed following hypothermia. Therefore, the present study provided evidence that IL‑2 treatment combined with MFH improves the therapeutic effect on lung cancer‑bearing mice.

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Copy and paste a formatted citation
Spandidos Publications style
Hu R, Ma S, Ke X, Jiang H, Wei D and Wang W: Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice. Biomed Rep 4: 59-62, 2016.
APA
Hu, R., Ma, S., Ke, X., Jiang, H., Wei, D., & Wang, W. (2016). Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice. Biomedical Reports, 4, 59-62. https://doi.org/10.3892/br.2015.540
MLA
Hu, R., Ma, S., Ke, X., Jiang, H., Wei, D., Wang, W."Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice". Biomedical Reports 4.1 (2016): 59-62.
Chicago
Hu, R., Ma, S., Ke, X., Jiang, H., Wei, D., Wang, W."Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice". Biomedical Reports 4, no. 1 (2016): 59-62. https://doi.org/10.3892/br.2015.540
Copy and paste a formatted citation
x
Spandidos Publications style
Hu R, Ma S, Ke X, Jiang H, Wei D and Wang W: Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice. Biomed Rep 4: 59-62, 2016.
APA
Hu, R., Ma, S., Ke, X., Jiang, H., Wei, D., & Wang, W. (2016). Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice. Biomedical Reports, 4, 59-62. https://doi.org/10.3892/br.2015.540
MLA
Hu, R., Ma, S., Ke, X., Jiang, H., Wei, D., Wang, W."Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice". Biomedical Reports 4.1 (2016): 59-62.
Chicago
Hu, R., Ma, S., Ke, X., Jiang, H., Wei, D., Wang, W."Effect of interleukin‑2 treatment combined with magnetic fluid hyperthermia on Lewis lung cancer‑bearing mice". Biomedical Reports 4, no. 1 (2016): 59-62. https://doi.org/10.3892/br.2015.540
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