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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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June-2016 Volume 4 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women

  • Authors:
    • Jiao Zhang
    • Bin Zhang

  • View Affiliations / Copyright

    Affiliations: Obstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, P.R. China
  • Pages: 715-718
    |
    Published online on: April 13, 2016
       https://doi.org/10.3892/br.2016.653
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Abstract

The aim of the present study was to evaluate the efficacy of using non-invasive DNA testing technology in screening Down's syndrome among women of advanced maternal age (AMA) and to provide evidence for prenatal screening of Down's syndrome. With a double-blind design, 8 ml of peripheral venous blood samples were collected from 87 women aged ≥35 years after 12 weeks of pregnancy. All cases were recorded with unique identification cards with clinical details and followed up until delivery. All the non‑invasive prenatal testing results were confirmed by amniotic fluid fetal karyotyping (the gold standard of aneuploidy test), follow‑up examination by neonatologists or neonatal blood karyotyping. The sensitivity, specificity and other indicators of non‑invasive DNA testing technology were calculated based on the data of 87 women of AMA. Among the 87 women of AMA, 5 were cases with abnormal numbers of chromosomes (3 cases of trisomy 21, 1 case of trisomy 18 and 1 case of 47, XXX). The sensitivity and specificity reached 100% for trisomy 21, trisomy 18 and 47, XXX. The present study supports that non‑invasive DNA testing is a useful method of AMA screening of Down's syndrome with 100% accuracy. Therefore, it can be used as an important alternative screening method for Down's syndrome in women of AMA.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J and Zhang B: Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women. Biomed Rep 4: 715-718, 2016.
APA
Zhang, J., & Zhang, B. (2016). Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women. Biomedical Reports, 4, 715-718. https://doi.org/10.3892/br.2016.653
MLA
Zhang, J., Zhang, B."Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women". Biomedical Reports 4.6 (2016): 715-718.
Chicago
Zhang, J., Zhang, B."Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women". Biomedical Reports 4, no. 6 (2016): 715-718. https://doi.org/10.3892/br.2016.653
Copy and paste a formatted citation
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Spandidos Publications style
Zhang J and Zhang B: Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women. Biomed Rep 4: 715-718, 2016.
APA
Zhang, J., & Zhang, B. (2016). Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women. Biomedical Reports, 4, 715-718. https://doi.org/10.3892/br.2016.653
MLA
Zhang, J., Zhang, B."Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women". Biomedical Reports 4.6 (2016): 715-718.
Chicago
Zhang, J., Zhang, B."Second-generation non-invasive high-throughput DNA sequencing technology in the screening of Down's syndrome in advanced maternal age women". Biomedical Reports 4, no. 6 (2016): 715-718. https://doi.org/10.3892/br.2016.653
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