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Print ISSN: 2049-9434 Online ISSN: 2049-9442
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September-2018 Volume 9 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study

  • Authors:
    • Pamela Frigerio
    • Ana Cecilia Cepeda-Nieto
    • Selim Marcos-Morales
    • Abel Peña-Velázquez
    • Sergio Dávila-Flores
    • Mauricio Salinas-Santander

  • View Affiliations / Copyright

    Affiliations: Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila 25000, Mexico, Departamento de Investigación, Facultad de Medicina Unidad Saltillo, Universidad Autónoma de Coahuila, Saltillo, Coahuila 25000, Mexico, Departamento de Cirugía, Hospital Universitario de Saltillo ‘Dr. Gonzalo Valdés Valdés’, Universidad Autónoma de Coahuila, Saltillo, Coahuila 2500, Mexico
  • Pages: 266-270
    |
    Published online on: July 3, 2018
       https://doi.org/10.3892/br.2018.1123
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Abstract

Biliary lithiasis is a multifactorial pathology determined by the interaction of genes and the environment, characterized by alterations in cholesterol homeostasis and in the metabolism of bile salts. A number of gene polymorphisms and mutations have been identified in the ATP-dependent cholesterol transporter (ABCG8) associated with lithiasis disease. The aim of the present study was to evaluate the association of the ABCG8 gene mutation IVS1-2A>G with cholecystolithiasis in patients from Northeast Mexico. This was a pilot study including 90 Mexican subjects diagnosed by ultrasonography, 57.8% of which presented gallstones. The studied parameters included: Lipid profile, total protein in plasma and polymerase chain reaction-restriction fragment length polymorphism genotyping. Significant differences were identified in total plasma protein, weight and BMI values, with these being these higher in subjects with gallstones (P<0.05). The presence of the mutant allele IVS1-2G was not detected, and the IVS1-2A wild-type allele was present in 100% of the population. Therefore, no association was apparent between the presence of the splice site mutation in ABCG8 (IVS1-2A>G) and the presence of gallstones in the evaluated subjects.

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Copy and paste a formatted citation
Spandidos Publications style
Frigerio P, Cepeda-Nieto AC, Marcos-Morales S, Peña-Velázquez A, Dávila-Flores S and Salinas-Santander M: Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study. Biomed Rep 9: 266-270, 2018.
APA
Frigerio, P., Cepeda-Nieto, A.C., Marcos-Morales, S., Peña-Velázquez, A., Dávila-Flores, S., & Salinas-Santander, M. (2018). Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study. Biomedical Reports, 9, 266-270. https://doi.org/10.3892/br.2018.1123
MLA
Frigerio, P., Cepeda-Nieto, A. C., Marcos-Morales, S., Peña-Velázquez, A., Dávila-Flores, S., Salinas-Santander, M."Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study". Biomedical Reports 9.3 (2018): 266-270.
Chicago
Frigerio, P., Cepeda-Nieto, A. C., Marcos-Morales, S., Peña-Velázquez, A., Dávila-Flores, S., Salinas-Santander, M."Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study". Biomedical Reports 9, no. 3 (2018): 266-270. https://doi.org/10.3892/br.2018.1123
Copy and paste a formatted citation
x
Spandidos Publications style
Frigerio P, Cepeda-Nieto AC, Marcos-Morales S, Peña-Velázquez A, Dávila-Flores S and Salinas-Santander M: Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study. Biomed Rep 9: 266-270, 2018.
APA
Frigerio, P., Cepeda-Nieto, A.C., Marcos-Morales, S., Peña-Velázquez, A., Dávila-Flores, S., & Salinas-Santander, M. (2018). Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study. Biomedical Reports, 9, 266-270. https://doi.org/10.3892/br.2018.1123
MLA
Frigerio, P., Cepeda-Nieto, A. C., Marcos-Morales, S., Peña-Velázquez, A., Dávila-Flores, S., Salinas-Santander, M."Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study". Biomedical Reports 9.3 (2018): 266-270.
Chicago
Frigerio, P., Cepeda-Nieto, A. C., Marcos-Morales, S., Peña-Velázquez, A., Dávila-Flores, S., Salinas-Santander, M."Distribution of the ATP-binding cassette transporter ABCG8 IVS1-2A>G genotype and clinical characteristics of gallbladder patients in Northeastern Mexico: A pilot study". Biomedical Reports 9, no. 3 (2018): 266-270. https://doi.org/10.3892/br.2018.1123
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