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Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis

  • Authors:
    • Katharina Dihm
    • Malin Ek
    • Bodil Roth
    • Bodil Ohlsson
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Skane University Hospital, Lund University, 205 02 Malmo, Sweden
    Copyright: © Dihm et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 211-221
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    Published online on: February 28, 2020
       https://doi.org/10.3892/br.2020.1282
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Abstract

The cytoplasmic protein AXIN1 is involved in the Wnt signalling pathway and its expression is increased in patients with endometriosis compared with healthy controls. The aim of the present cross‑sectional study was to further assess the levels of AXIN1 and other inflammatory biomarkers in patients with endometriosis. Patients with laparoscopy‑verified endometriosis were recruited (n=172) and completed a questionnaire regarding socioeconomic factors, lifestyle habits and medical history. Plasma AXIN1 and high‑sensitivity C‑reactive protein (hs‑CRP) levels were analysed by ELISA. The levels of calprotectin were determined in the faeces, and the haemoglobin concentration and number of erythrocytes, leukocytes and platelets were determined in the blood in a subgroup of 64 patients during clinical routine procedures. F‑calprotectin expression was detected in 18 women (28.1%), who had more severe constipation and more frequently experienced incomplete evacuation when defecating, and 5 women (7.8%) exhibited elevated levels. P‑AXIN1 levels were higher in patients who received hormonal treatment, and correlated inversely with faecal‑calprotectin levels (P=0.003), B‑haemoglobin levels (P=0.030) and the numbers of B‑erythrocytes (P=0.033) and B‑platelets (P=0.017), but were not correlated with hs‑CRP levels (P=0.818). Higher levels of AXIN1 were associated with the duration of the gastrointestinal symptoms and with diarrhoea, constipation, vomiting and nausea and the intestinal symptoms' effect on quality of life, and tended to be associated with the duration of endometriosis. Hs‑CRP expression was not associated with the clinical characteristics or symptoms of endometriosis, but higher levels were associated with obesity (P=0.002) and hormonal treatment (P=0.011). In conclusion, P‑AXIN1 expression was negatively correlated with certain inflammatory biomarkers and was positively associated with gastrointestinal symptoms. P‑AXIN1 levels were increased in patients who received hormonal treatment, highlighting the importance of obtaining native samples for future studies regarding its role in the development and presentation of endometriosis. However, hs‑CRP and other studied biomarkers seemed to be of no value for the assessment and diagnosis of endometriosis.
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Copy and paste a formatted citation
Spandidos Publications style
Dihm K, Ek M, Roth B and Ohlsson B: Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis. Biomed Rep 12: 211-221, 2020.
APA
Dihm, K., Ek, M., Roth, B., & Ohlsson, B. (2020). Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis. Biomedical Reports, 12, 211-221. https://doi.org/10.3892/br.2020.1282
MLA
Dihm, K., Ek, M., Roth, B., Ohlsson, B."Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis". Biomedical Reports 12.5 (2020): 211-221.
Chicago
Dihm, K., Ek, M., Roth, B., Ohlsson, B."Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis". Biomedical Reports 12, no. 5 (2020): 211-221. https://doi.org/10.3892/br.2020.1282
Copy and paste a formatted citation
x
Spandidos Publications style
Dihm K, Ek M, Roth B and Ohlsson B: Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis. Biomed Rep 12: 211-221, 2020.
APA
Dihm, K., Ek, M., Roth, B., & Ohlsson, B. (2020). Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis. Biomedical Reports, 12, 211-221. https://doi.org/10.3892/br.2020.1282
MLA
Dihm, K., Ek, M., Roth, B., Ohlsson, B."Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis". Biomedical Reports 12.5 (2020): 211-221.
Chicago
Dihm, K., Ek, M., Roth, B., Ohlsson, B."Plasma AXIN1 expression exhibit negative correlations with inflammatory biomarkers and is associated with gastrointestinal symptoms in endometriosis". Biomedical Reports 12, no. 5 (2020): 211-221. https://doi.org/10.3892/br.2020.1282
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