Open Access

Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)

  • Authors:
    • María Isabela Avila‑Rodríguez
    • David Meléndez‑Martínez
    • Cuauhtemoc Licona‑Cassani
    • José Manuel Aguilar‑Yañez
    • Jorge Benavides
    • Mirna Lorena Sánchez
  • View Affiliations

  • Published online on: April 27, 2020     https://doi.org/10.3892/br.2020.1300
  • Pages: 3-14
  • Copyright: © Avila‑Rodríguez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Skin wounds have been extensively studied as their healing represents a critical step towards achieving homeostasis following a traumatic event. Dependent on the severity of the damage, wounds are categorized as either acute or chronic. To date, chronic wounds have the highest economic impact as long term increases wound care costs. Chronic wounds affect 6.5 million patients in the United States with an annual estimated expense of $25 billion for the health care system. Among wound treatment categories, active wound care represents the fastest‑growing category due to its specific actions and lower costs. Within this category, proteases from various sources have been used as successful agents in debridement wound care. The wound healing process is predominantly mediated by matrix metalloproteinases (MMPs) that, when dysregulated, result in defective wound healing. Therapeutic activity has been described for animal secretions including fish epithelial mucus, maggot secretory products and snake venom, which contain secreted proteases (SPs). No further alternatives for use, sources or types of proteases used for wound healing have been found in the literature to date. Through the present review, the context of enzymatic wound care alternatives will be discussed. In addition, substrate homology of SPs and human MMPs will be compared and contrasted. The purpose of these discussions is to identify and propose the stages of wound healing in which SPs may be used as therapeutic agents to improve the wound healing process.

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July 2020
Volume 13 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Avila‑Rodríguez, M.I., Meléndez‑Martínez, D., Licona‑Cassani, C., Aguilar‑Yañez, J.M., Benavides, J., & Sánchez, M.L. (2020). Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review). Biomedical Reports, 13, 3-14. https://doi.org/10.3892/br.2020.1300
MLA
Avila‑Rodríguez, M. I., Meléndez‑Martínez, D., Licona‑Cassani, C., Aguilar‑Yañez, J. M., Benavides, J., Sánchez, M. L."Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)". Biomedical Reports 13.1 (2020): 3-14.
Chicago
Avila‑Rodríguez, M. I., Meléndez‑Martínez, D., Licona‑Cassani, C., Aguilar‑Yañez, J. M., Benavides, J., Sánchez, M. L."Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review)". Biomedical Reports 13, no. 1 (2020): 3-14. https://doi.org/10.3892/br.2020.1300