Open Access

Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)

  • Authors:
    • Hong Sun
    • Guoxuan Peng
    • Hongbin Wu
    • Miao Liu
    • Guping Mao
    • Xu Ning
    • Hua Yang
    • Jin Deng
  • View Affiliations

  • Published online on: May 15, 2020     https://doi.org/10.3892/br.2020.1305
  • Pages: 15-21
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight co‑ordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impairing bone metabolism and homeostasis. An increasing number of studies have shown that long non‑coding (lnc)RNAs are involved in osteogenic differentiation and thus serve an important role in the initiation, development, and progression of bone diseases such as tumors, osteoarthritis and osteoporosis. It has been reported that the lncRNA, maternally expressed gene 3 (MEG3), regulates osteogenic differentiation of multiple MSCs and also acts as a critical mediator in the development of bone formation and associated diseases. In the present review, the proposed mechanisms underlying the roles of MEG3 in osteogenic differentiation and its potential effects on bone diseases are discussed. These discussions may help elucidate the roles of MEG3 in osteogenic differentiation and highlight potential biomarkers and therapeutic targets for the treatment of bone diseases.

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July 2020
Volume 13 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Sun, H., Peng, G., Wu, H., Liu, M., Mao, G., Ning, X. ... Deng, J. (2020). Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review). Biomedical Reports, 13, 15-21. https://doi.org/10.3892/br.2020.1305
MLA
Sun, H., Peng, G., Wu, H., Liu, M., Mao, G., Ning, X., Yang, H., Deng, J."Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)". Biomedical Reports 13.1 (2020): 15-21.
Chicago
Sun, H., Peng, G., Wu, H., Liu, M., Mao, G., Ning, X., Yang, H., Deng, J."Long non‑coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)". Biomedical Reports 13, no. 1 (2020): 15-21. https://doi.org/10.3892/br.2020.1305