Open Access

Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)

  • Authors:
    • Fabio Parazzini
    • Elena Ricci
    • Francesco Fedele
    • Francesca Chiaffarino
    • Giovanna Esposito
    • Sonia Cipriani
  • View Affiliations

  • Published online on: June 15, 2022     https://doi.org/10.3892/br.2022.1552
  • Article Number: 69
  • Copyright: © Parazzini et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Several studies, reviews and meta‑analyses have documented that D‑mannose use lowers the risk of recurrent urinary tract infections (UTI), but its role in the treatment of UTI/cystitis‑related symptoms is unclear. In particular, no systematic review has analyzed the role of treatment with D-mannose in acute UTI/cystitis. In this paper, we systematically reviewed the published data on the effect of D‑mannose, alone or in association with other compounds, on the typical symptoms of UTI/cystitis. PubMed/Medline and EMBASE databases were searched, from 1990 to January 2022, using combinations of the following keywords: ‘urinary tract infections’, ‘cystalgia’, ‘recurrent next urinary tract infection’, ‘cystitis’, ‘mannose’, ‘mannoside’, ‘D‑mannose’, ‘bacteriuria’, ‘pyuria’, ‘pyelocystitis’ with the appropriate Boolean modifiers (Limits: Human, English, full article). Studies were selected for the systematic review if they were clinical studies and reported original data, the number of patients using D‑mannose alone or in association with other treatments, and the number of patients with symptoms of UTI/cystitis at trial entry and after the follow‑up period. A total of seven studies were identified. D‑mannose was given alone in two studies, and was associated with cranberry extract, Morinda citrifolia fruit extract, pomegranate extract, fructo‑oligosaccharides, lactobacilli, and N‑acetylcysteine in the others. All studies reported that symptoms decreased after treatment with D‑mannose. Despite the limitations of the studies, the consistent results observed among all studies give support to the general findings that D‑mannose may be useful in the treatment of UTI/cystitis symptoms.

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August-2022
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Spandidos Publications style
Parazzini F, Ricci E, Fedele F, Chiaffarino F, Esposito G and Cipriani S: Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review). Biomed Rep 17: 69, 2022
APA
Parazzini, F., Ricci, E., Fedele, F., Chiaffarino, F., Esposito, G., & Cipriani, S. (2022). Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review). Biomedical Reports, 17, 69. https://doi.org/10.3892/br.2022.1552
MLA
Parazzini, F., Ricci, E., Fedele, F., Chiaffarino, F., Esposito, G., Cipriani, S."Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)". Biomedical Reports 17.2 (2022): 69.
Chicago
Parazzini, F., Ricci, E., Fedele, F., Chiaffarino, F., Esposito, G., Cipriani, S."Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)". Biomedical Reports 17, no. 2 (2022): 69. https://doi.org/10.3892/br.2022.1552