Open Access

Biological effects of extracorporeal shockwave therapy in tendons: A systematic review

  • Authors:
    • Daniela Poenaru
    • Miruna Ioana Sandulescu
    • Delia Cinteza
  • View Affiliations

  • Published online on: December 29, 2022     https://doi.org/10.3892/br.2022.1597
  • Article Number: 15
  • Copyright: © Poenaru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Extracorporeal shockwave therapy was initially used for kidney stone disintegration and its application was then extended to calcific tendinitis. The therapeutic field expanded and included numerous types of tendinopathies, from shoulder to plantar fascia. The clinical benefits were documented in trials and the effects and mechanisms were studied on models including animal and human tendons. The present systematic review outlines a large spectrum of biological effects. First, an optimal dose is adapted for each species and each tendon; exceeding the optimal dose may lead to structural injury. Furthermore, the biological effects may be grouped into neovascularization induction, cellularity and extracellular matrix changes, metalloprotease and cytokine modulation, as well as lubricin production. As a result, the remodeled tendon displays improved biomechanical properties to resist stress.

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February-2023
Volume 18 Issue 2

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Copy and paste a formatted citation
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Spandidos Publications style
Poenaru D, Sandulescu MI and Cinteza D: Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomed Rep 18: 15, 2023
APA
Poenaru, D., Sandulescu, M.I., & Cinteza, D. (2023). Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomedical Reports, 18, 15. https://doi.org/10.3892/br.2022.1597
MLA
Poenaru, D., Sandulescu, M. I., Cinteza, D."Biological effects of extracorporeal shockwave therapy in tendons: A systematic review". Biomedical Reports 18.2 (2023): 15.
Chicago
Poenaru, D., Sandulescu, M. I., Cinteza, D."Biological effects of extracorporeal shockwave therapy in tendons: A systematic review". Biomedical Reports 18, no. 2 (2023): 15. https://doi.org/10.3892/br.2022.1597