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Biological effects of extracorporeal shockwave therapy in tendons: A systematic review

  • Authors:
    • Daniela Poenaru
    • Miruna Ioana Sandulescu
    • Delia Cinteza
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania, Doctoral School, Clinical Pharmacology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Poenaru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
    |
    Published online on: December 29, 2022
       https://doi.org/10.3892/br.2022.1597
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Abstract

Extracorporeal shockwave therapy was initially used for kidney stone disintegration and its application was then extended to calcific tendinitis. The therapeutic field expanded and included numerous types of tendinopathies, from shoulder to plantar fascia. The clinical benefits were documented in trials and the effects and mechanisms were studied on models including animal and human tendons. The present systematic review outlines a large spectrum of biological effects. First, an optimal dose is adapted for each species and each tendon; exceeding the optimal dose may lead to structural injury. Furthermore, the biological effects may be grouped into neovascularization induction, cellularity and extracellular matrix changes, metalloprotease and cytokine modulation, as well as lubricin production. As a result, the remodeled tendon displays improved biomechanical properties to resist stress.
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Copy and paste a formatted citation
Spandidos Publications style
Poenaru D, Sandulescu MI and Cinteza D: Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomed Rep 18: 15, 2023.
APA
Poenaru, D., Sandulescu, M.I., & Cinteza, D. (2023). Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomedical Reports, 18, 15. https://doi.org/10.3892/br.2022.1597
MLA
Poenaru, D., Sandulescu, M. I., Cinteza, D."Biological effects of extracorporeal shockwave therapy in tendons: A systematic review". Biomedical Reports 18.2 (2023): 15.
Chicago
Poenaru, D., Sandulescu, M. I., Cinteza, D."Biological effects of extracorporeal shockwave therapy in tendons: A systematic review". Biomedical Reports 18, no. 2 (2023): 15. https://doi.org/10.3892/br.2022.1597
Copy and paste a formatted citation
x
Spandidos Publications style
Poenaru D, Sandulescu MI and Cinteza D: Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomed Rep 18: 15, 2023.
APA
Poenaru, D., Sandulescu, M.I., & Cinteza, D. (2023). Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomedical Reports, 18, 15. https://doi.org/10.3892/br.2022.1597
MLA
Poenaru, D., Sandulescu, M. I., Cinteza, D."Biological effects of extracorporeal shockwave therapy in tendons: A systematic review". Biomedical Reports 18.2 (2023): 15.
Chicago
Poenaru, D., Sandulescu, M. I., Cinteza, D."Biological effects of extracorporeal shockwave therapy in tendons: A systematic review". Biomedical Reports 18, no. 2 (2023): 15. https://doi.org/10.3892/br.2022.1597
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