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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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December-2014 Volume 8 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment

  • Authors:
    • Guimin Zheng
    • Lei Wang
    • Xiuchuan Jia
    • Fang Li
    • Yonglong Yan
    • Zhibo Yu
    • Li Li
    • Qun Wei
    • Fengxiao Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, Hebei Province General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Medicine Imaging, Hebei Province General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Ultrasound Imaging, Hebei Province General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Nosocomial Infection Control, Hebei Province General Hospital, Shijiazhuang, Hebei 050051, P.R. China
  • Pages: 1807-1812
    |
    Published online on: October 1, 2014
       https://doi.org/10.3892/etm.2014.2001
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Abstract

The aim of the present study was to explore the use of high frequency color Doppler ultrasound to measure synovial thickness and blood flow to assess the therapeutic value of the recombinant human tumor necrosis factor (TNF) Ⅱ receptor antibody fusion protein in rheumatoid arthritis (RA) treatment. A total of 36 clinically‑diagnosed patients with RA were treated with methotrexate tablets or the recombinant TNF‑receptor antibody fusion protein for 24 weeks. Joint synovial thickness and synovial blood flow integrity were monitored by high frequency color Doppler in the second metacarpophalangeal joint in one hand. The correlation of the erythrocyte sedimentation rate, C‑reactive protein (CRP) and 28‑joint disease activity score (DAS28) with the ultrasound parameters were analyzed. Metacarpophalangeal second joint 2 (MCP2) synovial thickness, wrist joint synovial thickness and MCP2 synovial blood flow, prior and subsequent to the treatment, have a high correlation with DAS28 (P<0.05), and the MCP2 synovial blood flow integral has a strong correlation with CRP. Evaluating the wrist joint synovial thickness and synovial integrity of the second metacarpophalangeal joint using high frequency ultrasound detection can effectively evaluate the disease status in patients with RA. This procedure is potentially valuable as a means of evaluating the curative effects of RA treatments.

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Copy and paste a formatted citation
Spandidos Publications style
Zheng G, Wang L, Jia X, Li F, Yan Y, Yu Z, Li L, Wei Q and Zhang F: Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment. Exp Ther Med 8: 1807-1812, 2014.
APA
Zheng, G., Wang, L., Jia, X., Li, F., Yan, Y., Yu, Z. ... Zhang, F. (2014). Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment. Experimental and Therapeutic Medicine, 8, 1807-1812. https://doi.org/10.3892/etm.2014.2001
MLA
Zheng, G., Wang, L., Jia, X., Li, F., Yan, Y., Yu, Z., Li, L., Wei, Q., Zhang, F."Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment". Experimental and Therapeutic Medicine 8.6 (2014): 1807-1812.
Chicago
Zheng, G., Wang, L., Jia, X., Li, F., Yan, Y., Yu, Z., Li, L., Wei, Q., Zhang, F."Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1807-1812. https://doi.org/10.3892/etm.2014.2001
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng G, Wang L, Jia X, Li F, Yan Y, Yu Z, Li L, Wei Q and Zhang F: Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment. Exp Ther Med 8: 1807-1812, 2014.
APA
Zheng, G., Wang, L., Jia, X., Li, F., Yan, Y., Yu, Z. ... Zhang, F. (2014). Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment. Experimental and Therapeutic Medicine, 8, 1807-1812. https://doi.org/10.3892/etm.2014.2001
MLA
Zheng, G., Wang, L., Jia, X., Li, F., Yan, Y., Yu, Z., Li, L., Wei, Q., Zhang, F."Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment". Experimental and Therapeutic Medicine 8.6 (2014): 1807-1812.
Chicago
Zheng, G., Wang, L., Jia, X., Li, F., Yan, Y., Yu, Z., Li, L., Wei, Q., Zhang, F."Application of high frequency color Doppler ultrasound in the monitoring of rheumatoid arthritis treatment". Experimental and Therapeutic Medicine 8, no. 6 (2014): 1807-1812. https://doi.org/10.3892/etm.2014.2001
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