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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August-2016 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Case Report Open Access

Orthodontic treatment of a patient with cleidocranial dysplasia: A case report

  • Authors:
    • Zi‑Jian Li
    • Jun‑Yan Wang
    • Ming‑Fei Gao
    • Da‑Lei Wu
    • Xin Chang

  • View Affiliations / Copyright

    Affiliations: Department of Orthodontics, Dental and Stomatologic Clinic, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Stomatology, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Orthodontics, Dental and Stomatologic Clinic, Fushun Central Hospital, Fushun, Liaoning 113006, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 690-694
    |
    Published online on: June 6, 2016
       https://doi.org/10.3892/etm.2016.3430
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Abstract

Cleidocranial dysplasia (CCD) is a rare autosomal dominant condition that affects ossification. The dental abnormalities associated with CCD present an obstacle to orthodontic treatment planning. Early diagnosis is crucial to provide the patient with different treatment modalities that will suit the particular patient. In the present case, combined surgical and orthodontic treatment were performed to guide multiple impacted teeth. A single nucleotide missense variation was identified in exon 3 of runt‑related transcription factor 2 (RUNX2) in this patient. The current results suggest a correlation between dental alterations and mutations in the runt domain of RUNX2 in CCD patients. Further clinical and genetic studies may required to confirm the association between phenotypes and genotypes in CCD and to identify other factors that may influence the clinical features of this disease. Patients with cleidocranial dysplasia require a team approach which demands good communication and cooperation from the patient. Timing of the intervention is critical, and numerous surgeries may be required. The patient in the present case report was treated by a team of practitioners, which involved several dental specialties to achieve an optimal result.

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Copy and paste a formatted citation
Spandidos Publications style
Li ZJ, Wang JY, Gao MF, Wu DL and Chang X: Orthodontic treatment of a patient with cleidocranial dysplasia: A case report. Exp Ther Med 12: 690-694, 2016.
APA
Li, Z., Wang, J., Gao, M., Wu, D., & Chang, X. (2016). Orthodontic treatment of a patient with cleidocranial dysplasia: A case report. Experimental and Therapeutic Medicine, 12, 690-694. https://doi.org/10.3892/etm.2016.3430
MLA
Li, Z., Wang, J., Gao, M., Wu, D., Chang, X."Orthodontic treatment of a patient with cleidocranial dysplasia: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 690-694.
Chicago
Li, Z., Wang, J., Gao, M., Wu, D., Chang, X."Orthodontic treatment of a patient with cleidocranial dysplasia: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 690-694. https://doi.org/10.3892/etm.2016.3430
Copy and paste a formatted citation
x
Spandidos Publications style
Li ZJ, Wang JY, Gao MF, Wu DL and Chang X: Orthodontic treatment of a patient with cleidocranial dysplasia: A case report. Exp Ther Med 12: 690-694, 2016.
APA
Li, Z., Wang, J., Gao, M., Wu, D., & Chang, X. (2016). Orthodontic treatment of a patient with cleidocranial dysplasia: A case report. Experimental and Therapeutic Medicine, 12, 690-694. https://doi.org/10.3892/etm.2016.3430
MLA
Li, Z., Wang, J., Gao, M., Wu, D., Chang, X."Orthodontic treatment of a patient with cleidocranial dysplasia: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 690-694.
Chicago
Li, Z., Wang, J., Gao, M., Wu, D., Chang, X."Orthodontic treatment of a patient with cleidocranial dysplasia: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 690-694. https://doi.org/10.3892/etm.2016.3430
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