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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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February-2017 Volume 13 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells

  • Authors:
    • Xiaojuan Zhu
    • Licong Yang
    • Feng Xu
    • Lezhen Lin
    • Guodong Zheng

  • View Affiliations / Copyright

    Affiliations: Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, P.R. China
  • Pages: 688-694
    |
    Published online on: December 15, 2016
       https://doi.org/10.3892/etm.2016.3975
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Abstract

Catechins and caffeine, which are green tea components, have a slimming effect; however, the combinational effect of fat metabolism in 3T3‑L1 cells remains unclear. In the present study, 3T3‑L1 cells were treated with catechins and caffeine in combination, and it was found that combination therapy with catechins and caffeine markedly reduced intracellular fat accumulation, mRNA expression levels of peroxisome proliferator‑activated receptor‑γ and CCAAT/enhancer-binding protein α in the early stage of cell differentiation were significantly reduced, and mRNA expression of fatty acid synthetase (FAS) and glycerol‑3‑phosphate dehydrogenase protein expression levels of FAS were downregulated. Noradrenaline‑induced lipolysis was enhanced by caffeine, which markedly increased the protein expression of adipose triglyceride lipase and hormone sensitive lipase. These results indicated that combination therapy with catechins and caffeine synergistically inhibited lipid accumulation by regulating the gene and protein expression levels of lipid metabolism‑related enzymes. Therefore, catechins and caffeine combination therapy has potential as a functional food that may be used to prevent obesity and lifestyle-associated diseases.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu X, Yang L, Xu F, Lin L and Zheng G: Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells. Exp Ther Med 13: 688-694, 2017.
APA
Zhu, X., Yang, L., Xu, F., Lin, L., & Zheng, G. (2017). Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells. Experimental and Therapeutic Medicine, 13, 688-694. https://doi.org/10.3892/etm.2016.3975
MLA
Zhu, X., Yang, L., Xu, F., Lin, L., Zheng, G."Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells". Experimental and Therapeutic Medicine 13.2 (2017): 688-694.
Chicago
Zhu, X., Yang, L., Xu, F., Lin, L., Zheng, G."Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells". Experimental and Therapeutic Medicine 13, no. 2 (2017): 688-694. https://doi.org/10.3892/etm.2016.3975
Copy and paste a formatted citation
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Spandidos Publications style
Zhu X, Yang L, Xu F, Lin L and Zheng G: Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells. Exp Ther Med 13: 688-694, 2017.
APA
Zhu, X., Yang, L., Xu, F., Lin, L., & Zheng, G. (2017). Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells. Experimental and Therapeutic Medicine, 13, 688-694. https://doi.org/10.3892/etm.2016.3975
MLA
Zhu, X., Yang, L., Xu, F., Lin, L., Zheng, G."Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells". Experimental and Therapeutic Medicine 13.2 (2017): 688-694.
Chicago
Zhu, X., Yang, L., Xu, F., Lin, L., Zheng, G."Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells". Experimental and Therapeutic Medicine 13, no. 2 (2017): 688-694. https://doi.org/10.3892/etm.2016.3975
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