Comparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis

Fan,Qijun; Liu,Xuejun; Gao,Jinjian; Huang,Saiyu; Ni,Liyan

doi:10.3892/etm.2017.4032

February-2017 Volume 13 Issue 2

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February-2017 Volume 13 Issue 2

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Article

Comparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis

Authors:
- Qijun Fan
- Xuejun Liu
- Jinjian Gao
- Saiyu Huang
- Liyan Ni
View Affiliations / Copyright

Affiliations: Desensitization Treatment Center in the Department of Otolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325009, P.R. China, Department of Otorhinolaryngology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325009, P.R. China
Pages: 717-722
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Published online on: January 5, 2017

https://doi.org/10.3892/etm.2017.4032
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Abstract

The present study aimed to compare the efficacy and safety of subcutaneous immunotherapy with Dermatophagoides pteronyssinus standardized extract administered in conventional and cluster immunotherapy regiments for patients with persistent allergic rhinitis. A total of 60 patients with moderate to severe allergic rhinitis caused by dust mites were treated for 1 year with either conventional immunotherapy (n=30) or cluster immunotherapy (n=30). Nasal conjunctival symptoms and signs were assessed to evaluate the clinical efficacy of the two regimens, and the incidence of local and systemic adverse reactions were also evaluated. The findings demonstrated that the cluster regimen reduced the duration between the initial and maintenance dose by >60%, and resulted in a significant improvement, as compared with the conventional regimen, after 6 weeks of observation (P<0.05). However, the incidence of local and systemic adverse reactions in the cluster regimen during the dose accumulation phase and the dose maintenance phase was not significantly different, as compared with the conventional immunotherapy regimen. These results suggest that cluster immunotherapy is efficacious and safe to treat patients who are clinically sensitive to dust mites.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Comparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis

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Abstract

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