Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate

Tao,Ran; Wang,Zhong‑Feng; Qiu,Wei; He,Yu‑Fang; Yan,Wei‑Qun; Sun,Wen‑Yi; Li,Hai‑Jun

doi:10.3892/etm.2017.4294

June-2017 Volume 13 Issue 6

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June-2017 Volume 13 Issue 6

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Article Open Access

Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate

Authors:
- Ran Tao
- Zhong‑Feng Wang
- Wei Qiu
- Yu‑Fang He
- Wei‑Qun Yan
- Wen‑Yi Sun
- Hai‑Jun Li
View Affiliations / Copyright

Affiliations: Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Institute of Phytochemistry, Jilin Academy of Chinese Medicine Sciences, Changchun, Jilin 130012, P.R. China, Department of Clinical Pharmacy and Pharmaceutical Management, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China

Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2812-2818
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Published online on: April 4, 2017

https://doi.org/10.3892/etm.2017.4294
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Abstract

The fifth most common cancer worldwide is hepatocellular carcinoma (HCC), which has an annual mortality rate of ~800,000. Although surgical procedures for HCC, such as hepatic resection and liver transplantation, have progressed and the outcomes of patients have improved, HCC is still characterized by frequent recurrence, even after liver transplantation. In the present study the expression of the protein coding gene, S100 calcium binding protein A3 (S100A3), was observed in 62 HCC tissues and tumor‑surrounding tissues. The present study indicated that S100A3 activation was involved in tumorigenesis and tumor aggressiveness. The protein and mRNA expression levels of S100A3 in the human HCC cell line (HepG2) were investigated using western blotting and reverse transcription‑quantitative polymerase chain reaction analysis, respectively. The function of sodium cantharidinate in inducing HCC cell apoptosis was also investigated. Sodium cantharidinate inhibited the protein and gene expression of S100A3 in HepG2 cells in vitro. These data suggested that S100A3 has an important role in human HCC. The present study indicates that the functional properties of sodium cantharidinate are promising for the development of a novel drug that may control the expression of S100A3 and improve the treatment of human HCC in the near future.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of S100A3 in human hepatocellular carcinoma and the anticancer effect of sodium cantharidinate

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Abstract

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