Open Access

Seawater‑drowning‑induced acute lung injury: From molecular mechanisms to potential treatments (Review)

  • Authors:
    • Faguang Jin
    • Congcong Li
  • View Affiliations

  • Published online on: April 5, 2017     https://doi.org/10.3892/etm.2017.4302
  • Pages:2591-2598
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Drowning is a crucial public safety problem and is the third leading cause of accidental fatality, claiming ~372,000 lives annually, worldwide. In near‑drowning patients, acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is one of the most common complications. Approximately 1/3 of near‑drowning patients fulfill the criteria for ALI or ARDS. In the present article, the current literature of near‑drowning, pathophysiologic changes and the molecular mechanisms of seawater‑drowning‑induced ALI and ARDS was reviewed. Seawater is three times more hyperosmolar than plasma, and following inhalation of seawater the hyperosmotic seawater may cause serious injury in the lung and alveoli. The perturbing effects of seawater may be primarily categorized into insufficiency of pulmonary surfactant, blood‑air barrier disruption, formation of pulmonary edema, inflammation, oxidative stress, autophagy, apoptosis and various other hypertonic stimulation. Potential treatments for seawater‑induced ALI/ARDS were also presented, in addition to suggestions for further studies. A total of nine therapeutic strategies had been tested and all had focused on modulating the over‑activated immunoreactions. In conclusion, seawater drowning is a complex injury process and the exact mechanisms and potential treatments require further exploration.

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June 2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Jin, F., & Jin, F. (2017). Seawater‑drowning‑induced acute lung injury: From molecular mechanisms to potential treatments (Review). Experimental and Therapeutic Medicine, 13, 2591-2598. https://doi.org/10.3892/etm.2017.4302
MLA
Jin, F., Li, C."Seawater‑drowning‑induced acute lung injury: From molecular mechanisms to potential treatments (Review)". Experimental and Therapeutic Medicine 13.6 (2017): 2591-2598.
Chicago
Jin, F., Li, C."Seawater‑drowning‑induced acute lung injury: From molecular mechanisms to potential treatments (Review)". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2591-2598. https://doi.org/10.3892/etm.2017.4302
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