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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2017 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study

  • Authors:
    • Jianxi Zhu
    • Yuwei Liu
    • Yong Zhu
    • Min Zeng
    • Jie Xie
    • Pengfei Lei
    • Kanghua Li
    • Yihe Hu

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2862-2866
    |
    Published online on: April 19, 2017
       https://doi.org/10.3892/etm.2017.4360
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Abstract

The receptor activator of nuclear factor κB (RANK) axis is the fundamental signaling pathway in bone formation as well as bone tumor pathophysiology. The aim of the present study was to evaluate the impact of the expression of RANK and its downstream signaling molecule Akt1 on tumor progression in patients with osteosarcoma. Expression of RANK and Akt1 was examined in 78 human osteosarcoma samples by immunohistochemistry using formalin‑fixed samples. Following this, each graded immunohistochemistry result was correlated with clinicopathological parameters and patient survival. In total, 60 osteosarcomas (76.9%) expressed RANK and 58 cases (74.4%) showed expression of Akt1. In addition, expression of RANK was negatively correlated with disease‑free survival by Kaplan‑Meier analysis. A resistance was observed to chemotherapy in RANK‑expressing cases, which was statistically significant (P<0.05). In addition, chemotherapy and staging of the tumor were found to independent factors that have an effect on patient survival (P<0.05). Thus, RANK was identified as a negative prognostic factor of osteosarcoma survival.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Liu Y, Zhu Y, Zeng M, Xie J, Lei P, Li K and Hu Y: Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study. Exp Ther Med 13: 2862-2866, 2017.
APA
Zhu, J., Liu, Y., Zhu, Y., Zeng, M., Xie, J., Lei, P. ... Hu, Y. (2017). Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study. Experimental and Therapeutic Medicine, 13, 2862-2866. https://doi.org/10.3892/etm.2017.4360
MLA
Zhu, J., Liu, Y., Zhu, Y., Zeng, M., Xie, J., Lei, P., Li, K., Hu, Y."Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study". Experimental and Therapeutic Medicine 13.6 (2017): 2862-2866.
Chicago
Zhu, J., Liu, Y., Zhu, Y., Zeng, M., Xie, J., Lei, P., Li, K., Hu, Y."Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2862-2866. https://doi.org/10.3892/etm.2017.4360
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Liu Y, Zhu Y, Zeng M, Xie J, Lei P, Li K and Hu Y: Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study. Exp Ther Med 13: 2862-2866, 2017.
APA
Zhu, J., Liu, Y., Zhu, Y., Zeng, M., Xie, J., Lei, P. ... Hu, Y. (2017). Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study. Experimental and Therapeutic Medicine, 13, 2862-2866. https://doi.org/10.3892/etm.2017.4360
MLA
Zhu, J., Liu, Y., Zhu, Y., Zeng, M., Xie, J., Lei, P., Li, K., Hu, Y."Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study". Experimental and Therapeutic Medicine 13.6 (2017): 2862-2866.
Chicago
Zhu, J., Liu, Y., Zhu, Y., Zeng, M., Xie, J., Lei, P., Li, K., Hu, Y."Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study". Experimental and Therapeutic Medicine 13, no. 6 (2017): 2862-2866. https://doi.org/10.3892/etm.2017.4360
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