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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2017 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells

  • Authors:
    • Hong‑Mei An
    • Chen Lin
    • Chao Gu
    • Jin‑Jun Chen
    • Wen‑Xian Sun
    • Miao Jin
    • Tian‑Li Zhang
    • Ming‑Feng Qiu
    • Bing Hu

  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China, Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, The Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, P.R. China, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.R. China, Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, P.R. China
  • Pages: 3003-3008
    |
    Published online on: April 20, 2017
       https://doi.org/10.3892/etm.2017.4368
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Abstract

Traditional Chinese medicine can be used for Alzheimer's disease management, such as the modern herbal formula Di-Huang-Yi-Zhi (DHYZ). In the present study, neuronal differentiated PC12 cells were used as a model to evaluate the effects of DHYZ against amyloid‑β peptide 25‑35 (Aβ25‑35) induced neurotoxicity, particularly regarding cell proliferation, apoptosis and related events. Following treatment with DHYZ, cell viability, cell membrane damage, apoptosis, mitochondrial membrane potential, cytochrome c release, caspase‑3 activity and levels of reactive oxygen species in PC12 cells were detected. The results demonstrated that pretreatment with DHYZ significantly protected PC12 cells from Aβ25‑35‑induced proliferation inhibition, lactate dehydrogenase release and apoptosis, as well as upregulating mitochondrial membrane potential and downregulating cytochrome c release and caspase‑3 activation. DHYZ also inhibited the Aβ25‑35‑induced reactive oxygen species generation in PC12 cells. These observations suggest that DHYZ protected PC12 cells from the Aβ-induced neurotoxicity.

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Copy and paste a formatted citation
Spandidos Publications style
An HM, Lin C, Gu C, Chen JJ, Sun WX, Jin M, Zhang TL, Qiu MF and Hu B: Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells. Exp Ther Med 13: 3003-3008, 2017.
APA
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M. ... Hu, B. (2017). Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells. Experimental and Therapeutic Medicine, 13, 3003-3008. https://doi.org/10.3892/etm.2017.4368
MLA
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M., Zhang, T., Qiu, M., Hu, B."Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells". Experimental and Therapeutic Medicine 13.6 (2017): 3003-3008.
Chicago
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M., Zhang, T., Qiu, M., Hu, B."Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3003-3008. https://doi.org/10.3892/etm.2017.4368
Copy and paste a formatted citation
x
Spandidos Publications style
An HM, Lin C, Gu C, Chen JJ, Sun WX, Jin M, Zhang TL, Qiu MF and Hu B: Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells. Exp Ther Med 13: 3003-3008, 2017.
APA
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M. ... Hu, B. (2017). Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells. Experimental and Therapeutic Medicine, 13, 3003-3008. https://doi.org/10.3892/etm.2017.4368
MLA
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M., Zhang, T., Qiu, M., Hu, B."Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells". Experimental and Therapeutic Medicine 13.6 (2017): 3003-3008.
Chicago
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M., Zhang, T., Qiu, M., Hu, B."Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3003-3008. https://doi.org/10.3892/etm.2017.4368
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