Open Access

ABCG1 as a potential oncogene in lung cancer

  • Authors:
    • Chunyan Tian
    • Di Huang
    • Yanli Yu
    • Jihong Zhang
    • Qingxin Fang
    • Chao Xie
  • View Affiliations

  • Published online on: April 27, 2017     https://doi.org/10.3892/etm.2017.4393
  • Pages: 3189-3194
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

ATP-binding cassette transporter G1 (ABCG1) is a member of the ABC transporter family and regulates cellular cholesterol homeostasis. It has important roles in cholesterol homeostasis and tumor immunity, which has, however, not been reported in lung cancer. The present study showed that ABCG1 protein is upregulated in lung cancer compared with adjacent normal tissues and furthermore, aberrant ABCG1 expression was detected in lung cancer cell lines. ABCG1 was shown to promote the proliferation of HKULC4 lung cancer cells. Moreover, ABCG1 was found to regulate proliferation-, apoptosis- and cancer stem cell-associated markers in HKULC4 cells, implying that ABCG1 has important roles not only in the regulation of proliferation but also of apoptosis and cancer stem cells. A microRNA microarray analysis showed that ABCG1 significantly downregulated miR-29a, -b and -c expression in HKULC4 cells. Finally, it was demonstrated that ABCG1 promoted the migration and invasion in HKULC4 cells. Thus, ABCG1 may be a novel therapeutic target to improve the treatment of non-small cell lung cancer.

Related Articles

Journal Cover

June-2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tian C, Huang D, Yu Y, Zhang J, Fang Q and Xie C: ABCG1 as a potential oncogene in lung cancer. Exp Ther Med 13: 3189-3194, 2017
APA
Tian, C., Huang, D., Yu, Y., Zhang, J., Fang, Q., & Xie, C. (2017). ABCG1 as a potential oncogene in lung cancer. Experimental and Therapeutic Medicine, 13, 3189-3194. https://doi.org/10.3892/etm.2017.4393
MLA
Tian, C., Huang, D., Yu, Y., Zhang, J., Fang, Q., Xie, C."ABCG1 as a potential oncogene in lung cancer". Experimental and Therapeutic Medicine 13.6 (2017): 3189-3194.
Chicago
Tian, C., Huang, D., Yu, Y., Zhang, J., Fang, Q., Xie, C."ABCG1 as a potential oncogene in lung cancer". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3189-3194. https://doi.org/10.3892/etm.2017.4393