Expression and immunogenicity of NY‑ESO‑1 in colorectal cancer

  • Authors:
    • Ya Li
    • Ruifeng Song
    • Xinqiang Li
    • Feng Xu
  • View Affiliations

  • Published online on: April 28, 2017     https://doi.org/10.3892/etm.2017.4405
  • Pages: 3581-3585
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Abstract

Serum assays of NY-ESO-1 antibodies provide a guide to discriminate between patients who suffer from different types of cancer. In the present study, the expression of NY‑ESO‑1 was detected with the aim to identify a novel tumor antigen in colorectal cancer (CRC). Sera were obtained from 89 healthy individuals and 236 patients with CRC with stage I, II, III and IV tumors. The NY‑ESO‑1 autoantibody levels were determined using an enzyme‑linked immunosorbent assay. The mRNA and protein expression levels of NY‑ESO‑1 were detected using reverse transcription‑polymerase chain reaction and immunohistochemistry, respectively, in 60 CRC and paired adjacent non‑tumor tissues. NY‑ESO‑1 antibody was detected in 40 of the 236 (16.9%) patients with CRC. The NY‑ESO‑1 antibody combined with carcinoembryonic antigen enhanced the sensitivity, from 52.1 to 62.7%, of the diagnosis of CRC. The frequency of antibody positivity increased with the TNM cancer stage (8.8 vs. 28.3% in stages I+II and III+IV, respectively). The mRNA and protein expression levels of NY‑ESO‑1 were significantly higher in CRC tissue than in adjacent non‑tumor tissue. In conclusion, NY‑ESO‑1 is frequently expressed in CRC with the capacity of inducing a humoral immune response in CRC patients, exhibiting the potential to be a promising biomarker for CRC.

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June-2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Y, Song R, Li X and Xu F: Expression and immunogenicity of NY‑ESO‑1 in colorectal cancer. Exp Ther Med 13: 3581-3585, 2017
APA
Li, Y., Song, R., Li, X., & Xu, F. (2017). Expression and immunogenicity of NY‑ESO‑1 in colorectal cancer. Experimental and Therapeutic Medicine, 13, 3581-3585. https://doi.org/10.3892/etm.2017.4405
MLA
Li, Y., Song, R., Li, X., Xu, F."Expression and immunogenicity of NY‑ESO‑1 in colorectal cancer". Experimental and Therapeutic Medicine 13.6 (2017): 3581-3585.
Chicago
Li, Y., Song, R., Li, X., Xu, F."Expression and immunogenicity of NY‑ESO‑1 in colorectal cancer". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3581-3585. https://doi.org/10.3892/etm.2017.4405