Early clinical characteristics of bacterial endophthalmitis in retinopathy of prematurity after intravitreal bevacizumab injection: A case report

  • Authors:
    • Jianxun Wang
    • Daoman Xiang
  • View Affiliations

  • Published online on: April 28, 2017     https://doi.org/10.3892/etm.2017.4406
  • Pages: 3563-3566
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Abstract

Intravitreal bevacizumab injection (IVB) is emerging as a safe and effective therapy for retinopathy of prematurity (ROP); however, follow‑up investigations after IVB have indicated that endophthalmitis, a rare and devastating complication, may develop. The present study reports a case of an infant with ROP who developed endophthalmitis after IVB infection. The infant was administered with an intravitreal injection of broad‑spectrum antibiotics to treat the endophthalmitis. A favorable anatomic outcome was achieved after follow‑up. From this case, it was discovered that the early clinical characteristics of endophthalmitis infection secondary to IVB in premature infants include: i) The clinical symptoms of endophthalmitis infection appearing as early as 3‑5 days after IVB; ii) a white membranous plaque on the retina surface with an obscure circular boundary; iii) a plaque that enlarges to a gray flocculent mass and intrudes the vitreous body, where the hazing surrounds the lesion; and iv) conjunctival hyperemia and cornea edema in the anterior segment of the affected eye. This case also indicated that timely retinal screening with RetCam or a binocular ophthalmoscope 3‑5 days after IVB may be effective for detecting early stage endophthalmitis in infants who are unable to complain of a loss of visual acuity. From the present case report, it is advisable that the same type of screening be performed 3‑5 days after other types of eye surgery, such as cataract extraction surgery, to detect early stage endophthalmitis. Furthermore, the present case also revealed that an early intravitreal injection of broad‑spectrum antibiotics may be an effective treatment for premature infants with bacterial endophthalmitis.

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June-2017
Volume 13 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang J and Wang J: Early clinical characteristics of bacterial endophthalmitis in retinopathy of prematurity after intravitreal bevacizumab injection: A case report. Exp Ther Med 13: 3563-3566, 2017
APA
Wang, J., & Wang, J. (2017). Early clinical characteristics of bacterial endophthalmitis in retinopathy of prematurity after intravitreal bevacizumab injection: A case report. Experimental and Therapeutic Medicine, 13, 3563-3566. https://doi.org/10.3892/etm.2017.4406
MLA
Wang, J., Xiang, D."Early clinical characteristics of bacterial endophthalmitis in retinopathy of prematurity after intravitreal bevacizumab injection: A case report". Experimental and Therapeutic Medicine 13.6 (2017): 3563-3566.
Chicago
Wang, J., Xiang, D."Early clinical characteristics of bacterial endophthalmitis in retinopathy of prematurity after intravitreal bevacizumab injection: A case report". Experimental and Therapeutic Medicine 13, no. 6 (2017): 3563-3566. https://doi.org/10.3892/etm.2017.4406