Green synthesis of copper nanoparticles using Eclipta prostrata leaves extract and their antioxidant and cytotoxic activities
Affiliations: Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 143 701, Republic of Korea, Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Vellore, Tamil Nadu 632 509, India, Department of Biochemistry, University of Otago, North Dunedin, Dunedin, Otago 9016, New Zealand
- Published online on: May 17, 2017 https://doi.org/10.3892/etm.2017.4466
- Pages: 18-24
Copyright: © Chung et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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The present study outlines the development of a method to synthesize copper nanoparticles (CuNPs) by mixing copper acetate solution with leaf extract of Eclipta prostrata without using any surfactant or external energy. E. prostrata leaf extract function as an excellent reducing agent of copper ions, and the biosynthesized CuNPs are safer for the environment. The powder X‑ray diffraction (XRD) pattern provided evidence for the formation of face‑centered cubic structure ranging from 23 to 57 nm, with an average size of 31±1.2 nm. Fourier transform infrared spectroscopy (FTIR) was used to identify the biomolecules and capping reagents in the E. prostrata leaf extract that may be responsible for the reduction of copper ions and the stability of the bioreduced nanoparticles. The biosynthesized CuNPs displayed considerable antioxidant capacity. Similarly, in vitro anticancer studies demonstrated the cytotoxicity value of synthesized CuNPs against tested HepG2 cells. The findings of the present study suggested that biosynthesized CuNPs that utilize extracts of E. prostrata may be used for therapeutic application, and thus are a promising nanomaterial.