Cordycepin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular muscle cells

  • Authors:
    • Li‑Jie Yan
    • Hai‑Tao Yang
    • Hong‑Yan Duan
    • Jin‑Tao Wu
    • Peng Qian
    • Xian‑Wei Fan
    • Shanling Wang
  • View Affiliations

  • Published online on: July 9, 2017     https://doi.org/10.3892/etm.2017.4746
  • Pages: 2335-2340
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Abstract

Atherosclerosis is a chronic inflammatory disease, which is associated with the increased expression of adhesion molecules in vascular smooth muscle cells (VSMCs). Cordycepin is one of the major bioactive components of Ophiocordyceps sinensis that has been demonstrated to exert anti‑atherogenic activity; however, its molecular mechanisms are poorly understood. The aim of the present study was to examine the in vitro effects of cordycepin on the tumor necrosis factor (TNF)‑α‑induced suppression of adhesion molecule expression. The results of the present study demonstrated that cordycepin markedly inhibited the expression of vascular cell adhesion molecule‑1 (VCAM‑1) and intercellular adhesion molecule‑1 (ICAM‑1) in TNF‑α‑stimulated human aortic vascular smooth muscle cells (HA‑VSMCs). Cordycepin significantly inhibited the TNF‑α‑induced mitogen‑activated protein kinase (MAPK) and protein kinase B (Akt) activation (P<0.05), markedly inhibited the TNF‑α‑induced expression level of nuclear factor (NF)‑κB p65 and markedly prevented the TNF‑α‑associated degradation of IκBα in HA‑VSMCs. The results of the present study suggest that cordycepin inhibits the expression of VCAM‑1 and ICAM‑1 in TNF‑α‑stimulated HA‑VSMCs via downregulating the MAPK/Akt/NF‑κB signaling pathway. Therefore, cordycepin may have a potential therapeutic application for preventing the advancement of atherosclerotic lesions.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yan LJ, Yang HT, Duan HY, Wu JT, Qian P, Fan XW and Wang S: Cordycepin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular muscle cells. Exp Ther Med 14: 2335-2340, 2017
APA
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., & Wang, S. (2017). Cordycepin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular muscle cells. Experimental and Therapeutic Medicine, 14, 2335-2340. https://doi.org/10.3892/etm.2017.4746
MLA
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., Wang, S."Cordycepin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular muscle cells". Experimental and Therapeutic Medicine 14.3 (2017): 2335-2340.
Chicago
Yan, L., Yang, H., Duan, H., Wu, J., Qian, P., Fan, X., Wang, S."Cordycepin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular muscle cells". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2335-2340. https://doi.org/10.3892/etm.2017.4746