Open Access

Altered functional connectivity in patients with post‑stroke memory impairment: A resting fMRI study

  • Authors:
    • Jiao Liu
    • Qin Wang
    • Feiwen Liu
    • Haiyan Song
    • Xiaofeng Liang
    • Zhengkun Lin
    • Wenjun Hong
    • Shanli Yang
    • Jia Huang
    • Guohua Zheng
    • Jing Tao
    • Li‑Dian Chen
  • View Affiliations

  • Published online on: July 10, 2017     https://doi.org/10.3892/etm.2017.4751
  • Pages: 1919-1928
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Post‑stroke memory dysfunction (PMD) is one of the most common forms of cognitive impairment among stroke survivors. However, only a limited number of studies have directly investigated the neural mechanisms associated with memory decline. The aim of the present study was to identify dynamic changes in the functional organization of the default mode network (DMN) and the dorsal attention network of patients with PMD. A total of 27 patients with PMD who experienced a stroke in the right hemisphere were enrolled in the current study, along with 27 healthy control subjects matched by age, sex, and educational level. A beha­vioral examination and functional magnetic resonance imaging scan were performed. The data were analyzed using an independent component analysis method. The results revealed a significantly increased functional connectivity between the DMN and prefrontal cortex (left middle/inferior frontal and left precentral gyri), temporal regions (left superior temporal gyrus), and bilateral and posterior cingulate gyri/precuneus (P<0.001). There was also a significantly decreased functional connectivity between the DMN and right middle temporal gyrus, left uvula, and right inferior parietal lobule, and between the dorsal attention network and prefrontal cortex (left precentral/inferior and right inferior/middle frontal gyri), right inferior parietal gyrus, and right insula (P<0.001). These results suggest that the stroke affected both the lesioned and contralesional hemispheres. The prefrontal cortex, temporal regions, insula, and posterior cingulate gyrus/precuneus serve a crucial role in memory processing.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu J, Wang Q, Liu F, Song H, Liang X, Lin Z, Hong W, Yang S, Huang J, Zheng G, Zheng G, et al: Altered functional connectivity in patients with post‑stroke memory impairment: A resting fMRI study. Exp Ther Med 14: 1919-1928, 2017
APA
Liu, J., Wang, Q., Liu, F., Song, H., Liang, X., Lin, Z. ... Chen, L. (2017). Altered functional connectivity in patients with post‑stroke memory impairment: A resting fMRI study. Experimental and Therapeutic Medicine, 14, 1919-1928. https://doi.org/10.3892/etm.2017.4751
MLA
Liu, J., Wang, Q., Liu, F., Song, H., Liang, X., Lin, Z., Hong, W., Yang, S., Huang, J., Zheng, G., Tao, J., Chen, L."Altered functional connectivity in patients with post‑stroke memory impairment: A resting fMRI study". Experimental and Therapeutic Medicine 14.3 (2017): 1919-1928.
Chicago
Liu, J., Wang, Q., Liu, F., Song, H., Liang, X., Lin, Z., Hong, W., Yang, S., Huang, J., Zheng, G., Tao, J., Chen, L."Altered functional connectivity in patients with post‑stroke memory impairment: A resting fMRI study". Experimental and Therapeutic Medicine 14, no. 3 (2017): 1919-1928. https://doi.org/10.3892/etm.2017.4751