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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line

  • Authors:
    • Qian Li
    • Jie Peng
    • Ting Liu
    • Guiying Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1935-1940
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    Published online on: July 11, 2017
       https://doi.org/10.3892/etm.2017.4769
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Abstract

Fas, which is an apoptotic‑related protein, has an important role in cell apoptosis. Fas ligand (FasL) binds to Fas and activates apoptosis signal transduction. We previously demonstrated that the efficiency of celecoxib inhibited the proliferation and apoptosis of HT‑29 colon cancer cell line. The BGC823 cell line was used as an experimental model to evaluate the potential role of celecoxib on gastric cancer cell apoptosis. Inhibitory effects of celecoxib on cell viability were determined by MTT assay. Cell apoptosis was evaluated by flow cytometric analysis and laser confocal microscopy. The results of the present study demonstrated that celecoxib inhibited the viability of BGC823 cells in a concentration‑ and time‑dependent manner. Furthermore, the effect of BGC823 cells apoptosis was increased in a concentration‑dependent manner. Western blotting was used to determine the protein expression levels of Fas, FasL, and B‑cell lymphoma‑2 (Bcl‑2). During the celecoxib‑induced apoptosis of BGC823 cells, celecoxib upregulated Fas expression and downregulated FasL and Bcl‑2 expression in a concentration‑dependent manner. These results suggest that celecoxib inhib­ited the growth and induced apoptosis of BGC823 gastric cancer cells by regulating the protein expression of Fas, FasL and Bcl‑2.

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Spandidos Publications style
Li Q, Peng J, Liu T and Zhang G: Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line. Exp Ther Med 14: 1935-1940, 2017.
APA
Li, Q., Peng, J., Liu, T., & Zhang, G. (2017). Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line. Experimental and Therapeutic Medicine, 14, 1935-1940. https://doi.org/10.3892/etm.2017.4769
MLA
Li, Q., Peng, J., Liu, T., Zhang, G."Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line". Experimental and Therapeutic Medicine 14.3 (2017): 1935-1940.
Chicago
Li, Q., Peng, J., Liu, T., Zhang, G."Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line". Experimental and Therapeutic Medicine 14, no. 3 (2017): 1935-1940. https://doi.org/10.3892/etm.2017.4769
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Peng J, Liu T and Zhang G: Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line. Exp Ther Med 14: 1935-1940, 2017.
APA
Li, Q., Peng, J., Liu, T., & Zhang, G. (2017). Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line. Experimental and Therapeutic Medicine, 14, 1935-1940. https://doi.org/10.3892/etm.2017.4769
MLA
Li, Q., Peng, J., Liu, T., Zhang, G."Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line". Experimental and Therapeutic Medicine 14.3 (2017): 1935-1940.
Chicago
Li, Q., Peng, J., Liu, T., Zhang, G."Effects of celecoxib on cell apoptosis and Fas, FasL and Bcl‑2 expression in a BGC‑823 human gastric cancer cell line". Experimental and Therapeutic Medicine 14, no. 3 (2017): 1935-1940. https://doi.org/10.3892/etm.2017.4769
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