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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes

  • Authors:
    • Chandong Ding
    • Cuicui Yang
    • Quanxia Cao
    • Xiaoxia Zhu
    • Jianming Zhang
    • Wen Zhang
    • Yongping Wang
    • Long Li

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Catheter Intervention Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2108-2116
    |
    Published online on: July 12, 2017
       https://doi.org/10.3892/etm.2017.4789
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Abstract

Currently, the mechanism of the chronotropic ability of stem cells modified to express the hyperpolarization‑activated cyclic nucleotide‑gated (HCN) gene remains to be elucidated. The present study assessed the effects of mouse (m)HCN2 gene modification on the expression of chronotropic relevant receptors, adrenergic receptor β1 (Adrb1) and cholinergic receptor muscarinic M2 (Chrm2), in bone marrow stromal cells (BMSCs) co‑cultured with atrial myocytes. BMSCs were divided into the following four groups: i) BMSCs transfected with the mHCN2 gene and co‑cultured with atrial myocytes for 48 h (TF + CO); ii) respective transfection (TF); iii) respective co‑culture (CO); and iv) the control group without treatment (CTL). Green fluorescent protein (GFP) was observed in the BMSCs 48 h after transfection with pEGFP‑C1‑mHCN2. The expression of Adrb1 and Chrm2 was significantly increased in the TF and TF + CO groups, particularly the TF + CO group, compared with the CTL group (P<0.05). This suggests that BMSCs modified to express the mHCN2 gene possess autorhythmicity and chronotropic ability, particularly when co‑cultured with atrial myocytes. The results of the present study provide novel information regarding the molecular basis of biological pacemakers' chronotropic ability.

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Copy and paste a formatted citation
Spandidos Publications style
Ding C, Yang C, Cao Q, Zhu X, Zhang J, Zhang W, Wang Y and Li L: Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes. Exp Ther Med 14: 2108-2116, 2017.
APA
Ding, C., Yang, C., Cao, Q., Zhu, X., Zhang, J., Zhang, W. ... Li, L. (2017). Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes. Experimental and Therapeutic Medicine, 14, 2108-2116. https://doi.org/10.3892/etm.2017.4789
MLA
Ding, C., Yang, C., Cao, Q., Zhu, X., Zhang, J., Zhang, W., Wang, Y., Li, L."Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes". Experimental and Therapeutic Medicine 14.3 (2017): 2108-2116.
Chicago
Ding, C., Yang, C., Cao, Q., Zhu, X., Zhang, J., Zhang, W., Wang, Y., Li, L."Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2108-2116. https://doi.org/10.3892/etm.2017.4789
Copy and paste a formatted citation
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Spandidos Publications style
Ding C, Yang C, Cao Q, Zhu X, Zhang J, Zhang W, Wang Y and Li L: Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes. Exp Ther Med 14: 2108-2116, 2017.
APA
Ding, C., Yang, C., Cao, Q., Zhu, X., Zhang, J., Zhang, W. ... Li, L. (2017). Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes. Experimental and Therapeutic Medicine, 14, 2108-2116. https://doi.org/10.3892/etm.2017.4789
MLA
Ding, C., Yang, C., Cao, Q., Zhu, X., Zhang, J., Zhang, W., Wang, Y., Li, L."Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes". Experimental and Therapeutic Medicine 14.3 (2017): 2108-2116.
Chicago
Ding, C., Yang, C., Cao, Q., Zhu, X., Zhang, J., Zhang, W., Wang, Y., Li, L."Effect of mHCN2 gene modification on chronotropic relevant receptors in BMSCs co‑cultured with atrial myocytes". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2108-2116. https://doi.org/10.3892/etm.2017.4789
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