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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease

  • Authors:
    • Qiu‑Zan Zhang
    • Ying‑Li Liu
    • Yan‑Rong Wang
    • Li‑Na Fu
    • Jing Zhang
    • Xiu‑Ru Wang
    • Bang‑Mao Wang

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Tianjin Medical University, The Fourth Central Clinical College, Tianjin 300140, P.R. China, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
  • Pages: 2689-2694
    |
    Published online on: July 19, 2017
       https://doi.org/10.3892/etm.2017.4809
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Abstract

The present study aimed to investigate the impacts of telmisartan (TEL) on hepatic fibrosis, serum leptin, leptin protein in liver tissue and its mRNA expression level in rats with non‑alcoholic fatty liver disease (NAFLD). Male Sprague Dawley rats were randomly divided into the control (N), model (M), polyene phosphatidylcholine (P) and TEL (T) groups. Group M and the intervention groups were given a high‑fat diet for 12 weeks to induce NAFLD, followed by 4 weeks of intragastric administration of normal saline (1.0 ml/kg/day), polyene phosphatidylcholine (PPC; 123.1 mg/kg/day) and TEL (8 mg/kg/day). The liver tissue was then assessed for the NAFLD activity score and fibrosis score (FS), and serum biochemistry and leptin levels were determined. Additionally, leptin protein expression levels were examined by western blotting and the expression of leptin mRNA was investigated by reverse transcription‑polymerase chain reaction. TEL significantly improved FS in rats (P<0.01) and was more effective than PPC. TEL significantly reduced the expression of serum leptin, as well as the expression levels of leptin protein and its mRNA in liver tissue (P<0.01); however, the effects of PPC were not significant (P>0.05). TEL reduced serum leptin, leptin protein and its mRNA in the liver tissue of NAFLD rats, and improved the pathological indicators of liver fibrosis.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang QZ, Liu YL, Wang YR, Fu LN, Zhang J, Wang XR and Wang BM: Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease. Exp Ther Med 14: 2689-2694, 2017.
APA
Zhang, Q., Liu, Y., Wang, Y., Fu, L., Zhang, J., Wang, X., & Wang, B. (2017). Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease. Experimental and Therapeutic Medicine, 14, 2689-2694. https://doi.org/10.3892/etm.2017.4809
MLA
Zhang, Q., Liu, Y., Wang, Y., Fu, L., Zhang, J., Wang, X., Wang, B."Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease". Experimental and Therapeutic Medicine 14.3 (2017): 2689-2694.
Chicago
Zhang, Q., Liu, Y., Wang, Y., Fu, L., Zhang, J., Wang, X., Wang, B."Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2689-2694. https://doi.org/10.3892/etm.2017.4809
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang QZ, Liu YL, Wang YR, Fu LN, Zhang J, Wang XR and Wang BM: Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease. Exp Ther Med 14: 2689-2694, 2017.
APA
Zhang, Q., Liu, Y., Wang, Y., Fu, L., Zhang, J., Wang, X., & Wang, B. (2017). Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease. Experimental and Therapeutic Medicine, 14, 2689-2694. https://doi.org/10.3892/etm.2017.4809
MLA
Zhang, Q., Liu, Y., Wang, Y., Fu, L., Zhang, J., Wang, X., Wang, B."Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease". Experimental and Therapeutic Medicine 14.3 (2017): 2689-2694.
Chicago
Zhang, Q., Liu, Y., Wang, Y., Fu, L., Zhang, J., Wang, X., Wang, B."Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non‑alcoholic fatty liver disease". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2689-2694. https://doi.org/10.3892/etm.2017.4809
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